High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine <em>N</em>-oxide

doi:10.1126/science.aba3683

GSTDTAP > 气候变化

DOI	10.1126/science.aba3683
	High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
	Woongjae Yoo; Jacob K. Zieba; Nora J. Foegeding; Teresa P. Torres; Catherine D. Shelton; Nicolas G. Shealy; Austin J. Byndloss; Stephanie A. Cevallos; Erik Gertz; Connor R. Tiffany; Julia D. Thomas; Yael Litvak; Henry Nguyen; Erin E. Olsan; Brian J. Bennett; Jeffrey C. Rathmell; Amy S. Major; Andreas J. Bäumler; Mariana X. Byndloss
	2021-08-13
发表期刊	Science
出版年	2021
英文摘要	What people eat has an immediate selective effect on the microbial populations resident in the gut. A high-fat diet is associated with the occurrence of microbes that catabolize choline and the accumulation of trimethylamine N -oxide (TMAO) in the bloodstream, a contributing factor for heart disease. Yoo et al. explored the microbial organisms and pathways that convert choline into TMAO in mice. Although gene clusters for choline metabolism are found widely among the microbiota, it is only the facultative anaerobes that become abundant in hosts on a high-fat diet. A high-fat diet impairs mitochondrial uptake of oxygen into host enterocytes and elevates nitrate in the mucus, which in turn weakens healthy anaerobic gut function. Facultative anaerobes such as the pathobiont Escherichia coli become dominant, which leads to an overall increase in the amount of choline catabolized into the precursor for TMAO. Whether this pathway plays a role in heart disease remains unclear. Science , aba3683, this issue p. [813][1] A Western-style, high-fat diet promotes cardiovascular disease, in part because it is rich in choline, which is converted to trimethylamine (TMA) by the gut microbiota. However, whether diet-induced changes in intestinal physiology can alter the metabolic capacity of the microbiota remains unknown. Using a mouse model of diet-induced obesity, we show that chronic exposure to a high-fat diet escalates Escherichia coli choline catabolism by altering intestinal epithelial physiology. A high-fat diet impaired the bioenergetics of mitochondria in the colonic epithelium to increase the luminal bioavailability of oxygen and nitrate, thereby intensifying respiration-dependent choline catabolism of E. coli . In turn, E. coli choline catabolism increased levels of circulating trimethlamine N -oxide, which is a potentially harmful metabolite generated by gut microbiota. [1]: /lookup/doi/10.1126/science.aba3683
领域	气候变化 ; 资源环境
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/335890
专题	气候变化资源环境科学
推荐引用方式 GB/T 7714	Woongjae Yoo,Jacob K. Zieba,Nora J. Foegeding,等. High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide[J]. Science,2021.
APA	Woongjae Yoo.,Jacob K. Zieba.,Nora J. Foegeding.,Teresa P. Torres.,Catherine D. Shelton.,...&Mariana X. Byndloss.(2021).High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide.Science.
MLA	Woongjae Yoo,et al."High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide".Science (2021).