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This study investigated the microphysical responses to seeding giant aerosol particles and supersaturation fluctuations. A Lagrangian-particle-based DNS is used to resolve the interactions among individual aerosols, droplets, and the fluctuating supersaturation field within a turbulent, adiabatic air parcel. It is shown that the giant seeding particles exert strong solute effects throughout the entire simulation to alter the subsequent collision-coalescence process, implying the importance of including the solute term in droplet growth. Small-scale supersaturation fluctuations in adiabatic cloud regions have a negligible influence on aerosol activation and droplet condensation. This is because in regions free of entrainment and/or large-scale mixing, the weak supersaturation fluctuations can be quickly smoothed out via diffusion and remain relatively small in magnitude (with a standard deviation ). In contrast, the activation in our simulations is determined by the seeding modulation of the parcel-mean supersaturation.