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DOI | 10.1088/1748-9326/aa5528 |
Molybdenum chloride catalysts for Z-selective olefin metathesis reactions | |
Koh, Ming Joo1; Nguyen, Thach T.1; Lam, Jonathan K.2; Torker, Sebastian1; Hyvl, Jakub2; Schrock, Richard R.2; Hoveyda, Amir H.1 | |
2017-02-02 | |
发表期刊 | NATURE
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ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 542期号:7639页码:80-+ |
文章类型 | Article |
语种 | 英语 |
国家 | USA |
英文摘要 | The development of catalyst-controlled stereoselective olefin metathesis processes(1) has been a pivotal recent advance in chemistry. The incorporation of appropriate ligands within complexes based on molybdenum(2), tungsten(3) and ruthenium(4) has led to reactivity and selectivity levels that were previously inaccessible. Here we show that molybdenum monoaryloxide chloride complexes furnish higher-energy (Z) isomers of trifluoromethyl-substituted alkenes through cross-metathesis reactions with the commercially available, inexpensive and typically inert Z-1,1,1,4,4,4-hexafluoro-2-butene. Furthermore, otherwise inefficient and non-stereoselective transformations with Z-1,2-dichloroethene and 1,2-dibromoethene can be effected with substantially improved efficiency and Z selectivity. The use of such molybdenum monoaryloxide chloride complexes enables the synthesis of representative biologically active molecules and trifluoromethyl analogues of medicinally relevant compounds. The origins of the activity and selectivity levels observed, which contradict previously proposed principles(5), are elucidated with the aid of density functional theory calculations. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000396119300035 |
WOS关键词 | CROSS-METATHESIS ; TRIFLUOROMETHYLATION ; INHIBITOR ; COMPLEXES ; CHEMISTRY ; METAL ; ACID |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/35371 |
专题 | 气候变化 |
作者单位 | 1.Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA; 2.MIT, Dept Chem, Cambridge, MA 02139 USA |
推荐引用方式 GB/T 7714 | Koh, Ming Joo,Nguyen, Thach T.,Lam, Jonathan K.,et al. Molybdenum chloride catalysts for Z-selective olefin metathesis reactions[J]. NATURE,2017,542(7639):80-+. |
APA | Koh, Ming Joo.,Nguyen, Thach T..,Lam, Jonathan K..,Torker, Sebastian.,Hyvl, Jakub.,...&Hoveyda, Amir H..(2017).Molybdenum chloride catalysts for Z-selective olefin metathesis reactions.NATURE,542(7639),80-+. |
MLA | Koh, Ming Joo,et al."Molybdenum chloride catalysts for Z-selective olefin metathesis reactions".NATURE 542.7639(2017):80-+. |
条目包含的文件 | 条目无相关文件。 |
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