Global S&T Development Trend Analysis Platform of Resources and Environment
DOI | 10.1007/s00382-016-3120-9 |
CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses | |
Descours, Benjamin1; Petitjean, Gael1; Loepez-Zaragoza, Jose-Luis2,3,4,5; Bruel, Timothee2,3,6; Raffel, Raoul1; Psomas, Christina7; Reynes, Jacques7; Lacabaratz, Christine2,3,4,5; Levy, Yves2,3,4,5; Schwartz, Olivier2,3,6; Lelievre, Jean Daniel2,3,4,5; Benkirane, Monsef1 | |
2017-03-23 | |
发表期刊 | NATURE |
ISSN | 0028-0836 |
EISSN | 1476-4687 |
出版年 | 2017 |
卷号 | 543期号:7646页码:564-+ |
文章类型 | Article |
语种 | 英语 |
国家 | France |
英文摘要 | The persistence of the HIV reservoir in infected individuals is a major obstacle to the development of a cure for HIV1-3. Here, using an in vitro model of HIV-infected quiescent CD4 T cells, we reveal a gene expression signature of 103 upregulated genes that are specific for latently infected cells, including genes for 16 transmembrane proteins. In vitro screening for surface expression in HIV-infected quiescent CD4 T cells shows that the low-affinity receptor for the immunoglobulin G Fc fragment, CD32a, is the most highly induced, with no detectable expression in bystander cells. Notably, productive HIV-1 infection of T-cell-receptor-stimulated CD4 T cells is not associated with CD32a expression, suggesting that a quiescence-dependent mechanism is required for its induction. Using blood samples from HIV-1-positive participants receiving suppressive antiretroviral therapy, we identify a subpopulation of 0.012% of CD4 T cells that express CD32a and host up to three copies of HIV DNA per cell. This CD32a(+) reservoir was highly enriched in inducible replication-competent proviruses and can be predominant in some participants. Our discovery that CD32a(+) lymphocytes represent the elusive HIV-1 reservoir may lead to insights that will facilitate the specific targeting and elimination of this reservoir. |
领域 | 地球科学 ; 气候变化 ; 资源环境 |
收录类别 | SCI-E |
WOS记录号 | WOS:000397018000054 |
WOS关键词 | BROADLY NEUTRALIZING ANTIBODIES ; ACTIVE ANTIRETROVIRAL THERAPY ; FC-GAMMA RECEPTORS ; LATENT RESERVOIR ; SAMHD1 ; INFECTION ; MACROPHAGES ; INTEGRATION ; VPX |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.173/C666/handle/2XK7JSWQ/36224 |
专题 | 气候变化 |
作者单位 | 1.Univ Montpellier, CNRS, UMR9002, Inst Genet Humaine,Lab Virol Moleculaire, Montpellier, France; 2.Univ Paris Est, Fac Med, Vaccine Res Inst, INSERM U955, Creteil, France; 3.Serv Immunol Clin, Assistance Publ Hopitaux Paris, Grp Henri Mondor Albert Chenevier, Creteil, France; 4.INSERM, Equipe 16, Creteil, France; 5.Hop Henri Mondor Albert Chenevier, AP HP, Serv Immunol Clin & Malad Infectieuses, F-94000 Creteil, France; 6.CNRS, URA 3015, Inst Pasteur, Virus & Immun Unit, Paris, France; 7.Hop Univ, Dept Malad Infectieuses & Trop, Montpellier, France |
推荐引用方式 GB/T 7714 | Descours, Benjamin,Petitjean, Gael,Loepez-Zaragoza, Jose-Luis,et al. CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses[J]. NATURE,2017,543(7646):564-+. |
APA | Descours, Benjamin.,Petitjean, Gael.,Loepez-Zaragoza, Jose-Luis.,Bruel, Timothee.,Raffel, Raoul.,...&Benkirane, Monsef.(2017).CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses.NATURE,543(7646),564-+. |
MLA | Descours, Benjamin,et al."CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses".NATURE 543.7646(2017):564-+. |
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