Neurodegeneration and adaptation in response to low-dose photon irradiation

doi:10.2172/1160350

GSTDTAP > 地球科学

DOI	10.2172/1160350
报告编号	Final report
来源ID	OSTI ID: 1160350
	Neurodegeneration and adaptation in response to low-dose photon irradiation
	Limoli, Charles L.
	2014-10-27
出版年	2014
语种	英语
国家	美国
领域	地球科学
英文摘要	Neural stem and precursor cells (i.e. multipotent neural cells) are concentrated in the neurogenic regions of the brain (hippocampal dentate gyrus, subventricular zones), and considerable evidence suggests that these cells are important in mediating the stress response of the CNS after damage from ionizing radiation. The capability of these cells to proliferate, migrate and differentiate (i.e. to undergo neurogenesis) suggests they can participate in the repair and maintenance of CNS functions by replacing brain cells damaged or depleted due to irradiation. Importantly, we have shown that multipotent neural cells are markedly sensitive to irradiation and oxidative stress, insults that compromise neurogenesis and hasten the onset and progression of degenerative processes that are likely to have an adverse impact on cognition. Our past and current work has demonstrated that relatively low doses of radiation cause a persistent (weeks-months) oxidative stress in multipotent neural cells that can elicit a range of degenerative sequelae in the CNS. Therefore, our project is focused on determining the extent that endogenous and redox sensitive multipotent neural cells represent important radioresponsive targets for low dose radiation effects. We hypothesize that the activation of redox sensitive signaling can trigger radioadaptive changes in these cells that can be either harmful or beneficial to overall cognitive health.
英文关键词	Low dose radiation adpatation
URL	查看原文
来源平台	US Department of Energy (DOE)
引用统计
文献类型	科技报告
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/6636
专题	地球科学
推荐引用方式 GB/T 7714	Limoli, Charles L.. Neurodegeneration and adaptation in response to low-dose photon irradiation,2014.