Quantifying Spatial AMR Patterns across Urban and Rural Landscapes

GSTDTAP

项目编号	NE/N019776/1
	Quantifying Spatial AMR Patterns across Urban and Rural Landscapes
	[unavailable]
主持机构	University of Strathclyde
项目开始年	2016
	2016-06-01
项目结束日期	2017-11-30
资助机构	UK-NERC
项目类别	Research Grant
国家	英国
语种	英语
英文摘要	Antimicrobial resistance is increasing in nature and threatens the effectiveness of our drug therapies and infection control. However, it remains difficult to distinguish what originates from human activities or what is natural. Therefore, we must extend the scale and depth monitoring efforts to better understand what is driving the increases in resistance traits. This project will use two collections of previously characterised soils to compare and contrast distributions of AR genes under widely varying conditions, ranging from urban, agriculture, legacy mining, and pristine rural environments. The project will utilise DNA extractions and new genetic technology to quantify over 230 AR genes in the samples. Soil inventories provide us well-characterised soils and the wealth of information that describes both the soils and the impacts at source locations. The project will generate an astonishing 120,000 AR-related data points (400 locations x 300 genes), each with extended background information on environmental conditions-creating among the largest geographic representation of AR gene distribution across landscapes ever created; sufficiently detailed to make cross-cutting observations of landscape effects on acquired vs innate AR levels. With advanced multi-parametric statistics, we will relate specific environmental conditions and factors with observed AR genes levels in soils to identify risk factors associated resistance development and impacts on human and agricultural health.
来源学科分类	Natural Environment Research
文献类型	项目
条目标识符	http://119.78.100.173/C666/handle/2XK7JSWQ/86205
专题	环境与发展全球科技态势
推荐引用方式 GB/T 7714	[unavailable].Quantifying Spatial AMR Patterns across Urban and Rural Landscapes.2016.