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A reference map of the human binary protein interactome 期刊论文
NATURE, 2020, 580 (7803) : 402-+
作者:  Fan, Chen;  Sukomon, Nattakan;  Flood, Emelie;  Rheinberger, Jan;  Allen, Toby W.;  Nimigean, Crina M.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships(1,2). Here we present a human '  all-by-all'  reference interactome map of human binary protein interactions, or '  HuRI'  . With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration of HuRI with genome(3), transcriptome(4) and proteome(5) data enables cellular function to be studied within most physiological or pathological cellular contexts. We demonstrate the utility of HuRI in identifying the specific subcellular roles of protein-protein interactions. Inferred tissue-specific networks reveal general principles for the formation of cellular context-specific functions and elucidate potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. HuRI is a systematic proteome-wide reference that links genomic variation to phenotypic outcomes.


  
Last appearance of Homo erectus at Ngandong, Java, 117,000-108,000 years ago 期刊论文
NATURE, 2020, 577 (7790) : 381-+
作者:  Haldane, Andy
收藏  |  浏览/下载:30/0  |  提交时间:2020/04/16

Homo erectus is the founding early hominin species of Island Southeast Asia, and reached Java (Indonesia) more than 1.5 million years ago(1,2). Twelve H. erectus calvaria (skull caps) and two tibiae (lower leg bones) were discovered from a bone bed located about 20 m above the Solo River at Ngandong (Central Java) between 1931 and 1933(3,4), and are of the youngest, most-advanced form of H. erectus(5-8). Despite the importance of the Ngandong fossils, the relationship between the fossils, terrace fill and ages have been heavily debated(9-14). Here, to resolve the age of the Ngandong evidence, we use Bayesian modelling of 52 radiometric age estimates to establish-to our knowledg-the first robust chronology at regional, valley and local scales. We used uranium-series dating of speleothems to constrain regional landscape evolution  luminescence, (40)argon/(39)argon (Ar-40/Ar-39) and uranium-series dating to constrain the sequence of terrace evolution  and applied uranium-series and uranium series-electron-spin resonance (US-ESR) dating to non-human fossils to directly date our re-excavation of Ngandong(5,15). We show that at least by 500 thousand years ago (ka) the Solo River was diverted into the Kendeng Hills, and that it formed the Solo terrace sequence between 316 and 31 ka and the Ngandong terrace between about 140 and 92 ka. Non-human fossils recovered during the re-excavation of Ngandong date to between 109 and 106 ka (uranium-series minimum)(16) and 134 and 118 ka (US-ESR), with modelled ages of 117 to 108 thousand years (kyr) for the H. erectus bone bed, which accumulated during flood conditions(3,17). These results negate the extreme ages that have been proposed for the site and solidify Ngandong as the last known occurrence of this long-lived species.


  
Chloride capture using a C-H hydrogen-bonding cage 期刊论文
SCIENCE, 2019, 365 (6449) : 159-+
作者:  Liu, Yun;  Zhao, Wei;  Chen, Chun-Hsing;  Flood, Amar H.
收藏  |  浏览/下载:2/0  |  提交时间:2019/11/27
Anthropogenic strath terrace formation caused by reduced sediment retention 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (18) : 8734-8739
作者:  Schanz, Sarah A.;  Montgomery, David R.;  Collins, Brian D.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Anthropocene  river incision  terrace formation  Pacific Northwest  
U-Pb constraints on pulsed eruption of the Deccan Traps across the end-Cretaceous mass extinction 期刊论文
SCIENCE, 2019, 363 (6429) : 862-+
作者:  Schoene, Blair;  Eddy, Michael P.;  Samperton, Kyle M.;  Keller, C. Brenhin;  Keller, Gerta;  Adatte, Thierry;  Khadri, Syed F. R.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Glacial lake outburst floods as drivers of fluvial erosion in the Himalaya 期刊论文
SCIENCE, 2018, 362 (6410) : 53-57
作者:  Cook, Kristen L.;  Andermann, Christoff;  Gimbert, Florent;  Adhikari, Basanta Raj;  Hovius, Niels
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Climatic control of Mississippi River flood hazard amplified by river engineering 期刊论文
NATURE, 2018, 556 (7699) : 95-+
作者:  Munoz, Samuel E.;  39;Donnell, Michelle
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/27
BENDING TO THE WATER'S WILL In flood-prone Bangladesh, resilience can mean letting water have its way 期刊论文
SCIENCE, 2018, 359 (6379) : 980-985
作者:  Cornwall, Warren
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
Changing character of rainfall in eastern China, 1951-2007 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (9) : 2016-2021
作者:  Day, Jesse A.;  Fung, Inez;  Liu, Weihan
收藏  |  浏览/下载:3/0  |  提交时间:2019/11/27
East Asian monsoon  monsoons  rainfall  Meiyu front  new methods  
Designing river flows to improve food security futures in the Lower Mekong Basin 期刊论文
SCIENCE, 2017, 358 (6368)
作者:  Sabo, J. L.;  Ruhi, A.;  Holtgrieve, G. W.;  Elliott, V.;  Arias, M. E.;  Ngor, Peng Bun;  Rasanen, T. A.;  Nam, So
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27