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Perspective: The future of liquid biopsy 期刊论文
NATURE, 2020, 579 (7800) : S9-S9
作者:  Silver, Andrew
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

The approach is starting to transform cancer diagnosis. Now the challenge is to make it a standard clinical tool, says Catherine Alix-Panabieres.


  
HACKS TO HELP RESEARCHERS PUT WORDS ON THE PAGE 期刊论文
NATURE, 2020, 580 (7801) : 151-153
作者:  Lee, Jiyoon;  Rabbani, Cyrus C.;  Gao, Hongyu;  Steinhart, Matthew R.;  Woodruff, Benjamin M.;  Pflum, Zachary E.;  Kim, Alexander;  Heller, Stefan;  Liu, Yunlong;  Shipchandler, Taha Z.;  Koehler, Karl R.
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Productivity coaches, boot camps and online meet-ups teach researchers to avoid distractions and negative thoughts to get their writing projects done.


Productivity coaches, boot camps and online meet-ups teach researchers to avoid distractions and negative thoughts to get their writing projects done.


  
Facebook needs to share more with researchers 期刊论文
NATURE, 2020, 579 (7800) : 473-473
作者:  Viglione, Giuliana
收藏  |  浏览/下载:2/0  |  提交时间:2020/07/03

Private companies get free access to data that are more informative than what researchers are forced to compete for.


Private companies get free access to data that are more informative than what researchers are forced to compete for.


  
The physics of ice skating 期刊论文
NATURE, 2020, 577 (7789) : 173-174
作者:  Bonn, Daniel
收藏  |  浏览/下载:0/0  |  提交时间:2020/07/03
EXPRESSION OF DOUBT 期刊论文
NATURE, 2020, 578 (7796) : 502-504
作者:  Benton, Donald J.;  Gamblin, Steven J.;  Rosenthal, Peter B.;  Skehel, John J.
收藏  |  浏览/下载:4/0  |  提交时间:2020/07/03

Although AI companies market software for recognizing emotions in faces, psychologists debate whether expressions can be read so easily.


Although AI companies market software for recognizing emotions in faces, psychologists debate whether expressions can be read so easily.


  
Lactonization as a general route to beta-C(sp(3))-H functionalization 期刊论文
NATURE, 2020, 577 (7792) : 656-+
作者:  Washington, Harriet A.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Functionalization of the beta-C-H bonds of aliphatic acids is emerging as a valuable synthetic disconnection that complements a wide range of conjugate addition reactions(1-5). Despite efforts for beta-C-H functionalization in carbon-carbon and carbon-heteroatom bond-forming reactions, these have numerous crucial limitations, especially for industrial-scale applications, including lack of mono-selectivity, use of expensive oxidants and limited scope(6-13). Notably, the majority of these reactions are incompatible with free aliphatic acids without exogenous directing groups. Considering the challenge of developing C-H activation reactions, it is not surprising that achieving different transformations requires independent catalyst design and directing group optimizations in each case. Here we report a Pd-catalysed beta-C(sp(3))-H lactonization of aliphatic acids enabled by a mono-N-protected beta-amino acid ligand. The highly strained and reactive beta-lactone products are versatile linchpins for the mono-selective installation of diverse alkyl, alkenyl, aryl, alkynyl, fluoro, hydroxyl and amino groups at the beta position of the parent acid, thus providing a route to many carboxylic acids. The use of inexpensive tert-butyl hydrogen peroxide as the oxidant to promote the desired selective reductive elimination from the Pd(IV) centre, as well as the ease of product purification without column chromatography, render this reaction amenable to tonne-scale manufacturing.


  
Is China coming to Russia's rescue? 期刊论文
NATURE, 2020, 579 (7799) : 320-320
作者:  Zastrow, Mark
收藏  |  浏览/下载:2/0  |  提交时间:2020/07/03

Vladimir Putin'  s government is strengthening research ties with China. That should not be at the expense of other global links.


Vladimir Putin'  s government is strengthening research ties with China. That should not be at the expense of other global links.


  
Accurate compound-specific C-14 dating of archaeological pottery vessels 期刊论文
NATURE, 2020, 580 (7804) : 506-+
作者:  Yin, Yafei;  Lu, J. Yuyang;  Zhang, Xuechun;  Shao, Wen;  Xu, Yanhui;  Li, Pan;  Hong, Yantao;  Cui, Li;  Shan, Ge;  Tian, Bin;  Zhang, Qiangfeng Cliff;  Shen, Xiaohua
收藏  |  浏览/下载:20/0  |  提交时间:2020/05/13

Pottery is one of the most commonly recovered artefacts from archaeological sites. Despite more than a century of relative dating based on typology and seriation(1), accurate dating of pottery using the radiocarbon dating method has proven extremely challenging owing to the limited survival of organic temper and unreliability of visible residues(2-4). Here we report a method to directly date archaeological pottery based on accelerator mass spectrometry analysis of C-14 in absorbed food residues using palmitic (C-16:0) and stearic (C-18:0) fatty acids purified by preparative gas chromatography(5-8). We present accurate compound-specific radiocarbon determinations of lipids extracted from pottery vessels, which were rigorously evaluated by comparison with dendrochronological dates(9,10) and inclusion in site and regional chronologies that contained previously determined radiocarbon dates on other materials(11-15). Notably, the compound-specific dates from each of the C-16:0 and C-18:0 fatty acids in pottery vessels provide an internal quality control of the results(6) and are entirely compatible with dates for other commonly dated materials. Accurate radiocarbon dating of pottery vessels can reveal: (1) the period of use of pottery  (2) the antiquity of organic residues, including when specific foodstuffs were exploited  (3) the chronology of sites in the absence of traditionally datable materials  and (4) direct verification of pottery typochronologies. Here we used the method to date the exploitation of dairy and carcass products in Neolithic vessels from Britain, Anatolia, central and western Europe, and Saharan Africa.


Using lipid residues absorbed in potsherds, the ages of pottery from various archaeological sites are determined and validated using sites for which the dates are well known from other methods.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Maria Victorina Lopez Varela: Turning the tide 期刊论文
NATURE, 2020, 581 (7807) : S20-S20
作者:  Zavaleta, Carol
收藏  |  浏览/下载:1/0  |  提交时间:2020/07/03

Pneumologist Maria Victorina Lopez Varela lays bare the scale of work required to prevent and treat COPD in the region.


Pneumologist Maria Victorina Lopez Varela lays bare the scale of work required to prevent and treat COPD in the region.