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How cancer genomics is transforming diagnosis and treatment 期刊论文
NATURE, 2020, 579 (7800) : S10-S11
作者:  Pacheco, Gustavo Gavrel
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

Genome sequencing is providing physicians with more data about the causes of cancer and changing the way some forms of the disease are treated.


Genome sequencing is providing physicians with more data about the causes of cancer and changing the way some forms of the disease are treated.


  
Not all driver mutations are equal 期刊论文
NATURE, 2020, 580 (7805) : 595-596
作者:  Legendre, Lucas J.;  Rubilar-Rogers, David;  Musser, Grace M.;  Davis, Sarah N.;  Otero, Rodrigo A.;  Vargas, Alexander O.;  Clarke, Julia A.
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

A study of cancer-associated mutations in normal endometrial glands of the uterus has now been performed using whole-genome sequencing. The analysis sheds light on the early changes that lead to invasive disease.


  
Neuronal gatekeeper for dementia protein 期刊论文
NATURE, 2020, 580 (7803) : 326-327
作者:  Bao, Pinglei;  She, Liang;  McGill, Mason;  Tsao, Doris Y.
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/03

In many neurodegenerative disorders, the spread of protein aggregates underlies disease progression in the brain. A receptor molecule has now been found that mediates the neuronal uptake of one such harmful protein. See p.381


  
The steroid debate 期刊论文
NATURE, 2020, 581 (7807) : S12-S13
作者:  Pagel, Mark
收藏  |  浏览/下载:3/0  |  提交时间:2020/07/03

Many people with chronic obstructive pulmonary disease are given steroids despite a lack of evidence underpinning their use.


Many people with chronic obstructive pulmonary disease are given steroids despite a lack of evidence underpinning their use.


  
Redefining a disease 期刊论文
NATURE, 2020, 581 (7807) : S4-S6
作者:  Castelvecchi, Davide
收藏  |  浏览/下载:1/0  |  提交时间:2020/07/03

Many people with symptoms of chronic obstructive pulmonary disease don'  t meet the criteria for diagnosis. The field is grappling with how to define and treat these patients.


Many people with symptoms of chronic obstructive pulmonary disease don'  t meet the criteria for diagnosis. The field is grappling with how to define and treat these patients.


  
Zombies in the lungs 期刊论文
NATURE, 2020, 581 (7807) : S7-S9
作者:  Adam, David
收藏  |  浏览/下载:0/0  |  提交时间:2020/07/03

Researchers are beginning to work out the part senescent cells play in the respiratory disease.


Researchers are beginning to work out the part senescent cells play in the respiratory disease.


  
Gut microbes tune inflammation and lifespan in a mouse model of amyotrophic lateral sclerosis 期刊论文
NATURE, 2020, 582 (7810) : 34-35
作者:  Mega, Emiliano Rodriguez
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/03

The microbiota modulates amyotrophic lateral sclerosis in an animal model.


There is growing evidence that gut microbes can influence disease. Analysis of a mouse model of the neurodegenerative condition amyotrophic lateral sclerosis offers insight into how gut bacteria might contribute to this illness.


  
Extra help for neuron grafts 期刊论文
NATURE, 2020, 582 (7810) : 39-40
作者:  Raz, Mical
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/03

Grafts of stem-cell-derived precursors of dopamine neurons could be used to treat Parkinson'  s disease, but this approach has limitations. Injecting a growth factor three weeks after transplantation can overcome some of these limits.


Steps to improve function and survival of dopamine-neuron transplants.


  
Lipid carrier breaks barrier in Alzheimer's disease 期刊论文
NATURE, 2020, 581 (7806) : 31-32
作者:  Leon-Velarde Servetto, Fabiola Maria
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

People who carry the gene variant APOE4 are at higher-than-average risk of developing Alzheimer'  s disease. It emerges that this variant is linked to defects in the blood-brain barrier and subsequent cognitive decline.


A link between APOE4 and breakdown of the blood-brain barrier.


  
Coming at cancer from all angles 期刊论文
NATURE, 2020, 580 (7804) : S24-S27
作者:  Ghasemi, Ali;  De Palma, Michele
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

The search for disease mechanisms and treatments is one of the biggest collaborative efforts in science. These researchers are significant contributors.


The search for disease mechanisms and treatments is one of the biggest collaborative efforts in science. These researchers are significant contributors.