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Oncotarget: Lung squamous cell carcinoma tumors reveal therapeutic alterations 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：4/0  |  提交时间：2021/06/07
Brain organoids uncover various mechanisms of virus-induced microcephaly 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：3/0  |  提交时间：2021/04/12
IU researchers discover new potential for functional recovery after spinal cord injury 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：0/0  |  提交时间：2021/03/12
Avian insights into human ciliopathies 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：3/0  |  提交时间：2021/02/17
New discovery could pave the way for improved treatments for diabetes 新闻
来源平台：EurekAlert. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：1/0  |  提交时间：2021/02/17
Water Dialogues - What's underground? Undervalued Groundwater 新闻
来源平台：Stockholm International Water Institute. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：10/0  |  提交时间：2021/01/22
A single genetic switch can lead to rapid evolution in sea anemones 新闻
来源平台：Science. 发布日期：2021
作者:  admin
收藏  |  浏览/下载：3/0  |  提交时间：2021/01/15
Healthcare for planets and humans: why looking after nature is good for mind, body, and the NHS 新闻
来源平台：UK Environment Agency. 发布日期：2020
作者:  admin
收藏  |  浏览/下载：8/0  |  提交时间：2020/09/09
Op-ed: International scholars are vital to American innovation and competitiveness 新闻
来源平台：Massachusetts Institute of Technology. 发布日期：2020
作者:  admin
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/16
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function 期刊论文
NATURE, 2020, 580 (7805) : 669-+
作者:  Kanarek, Naama;  Petrova, Boryana;  Sabatini, David M.
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/03

Cryo-electron microscopy structures of the DNA-binding domains of the pioneer transcription factor SOX2 and its close homologue SOX11 elucidate the role of these factors in initiating chromatin opening and nucleosome remodelling.


'  Pioneer'  transcription factors are required for stem-cell pluripotency, cell differentiation and cell reprogramming(1,2). Pioneer factors can bind nucleosomal DNA to enable gene expression from regions of the genome with closed chromatin. SOX2 is a prominent pioneer factor that is essential for pluripotency and self-renewal of embryonic stem cells(3). Here we report cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX11 bound to nucleosomes. The structures show that SOX factors can bind and locally distort DNA at superhelical location 2. The factors also facilitate detachment of terminal nucleosomal DNA from the histone octamer, which increases DNA accessibility. SOX-factor binding to the nucleosome can also lead to a repositioning of the N-terminal tail of histone H4 that includes residue lysine 16. We speculate that this repositioning is incompatible with higher-order nucleosome stacking, which involves contacts of the H4 tail with a neighbouring nucleosome. Our results indicate that pioneer transcription factors can use binding energy to initiate chromatin opening, and thereby facilitate nucleosome remodelling and subsequent transcription.