GSTDTAP

浏览/检索结果: 共16条,第1-10条 帮助

限定条件                    
已选(0)清除 条数/页:   排序方式:
Amagmatic Subduction Produced by Mantle Serpentinization and Oceanic Crust Delamination 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (9)
作者:  Yang, Jianfeng;  Lu, Gang;  Liu, Tong;  Li, Yang;  Wang, Kun;  Wang, Xinxin;  Sun, Baolu;  Faccenda, Manuele;  Zhao, Liang
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
numerical modeling  arc gap  flux melting  subduction zone  mantle serpentinization  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Urban Near-Surface Seismic Monitoring Using Distributed Acoustic Sensing 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (6)
作者:  Fang, Gang;  Li, Yunyue Elita;  Zhao, Yumin;  Martin, Eileen R.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
distributed acoustic sensing  urban seismology  near surface  passive seismic  seismic monitoring  
A molecular perovskite solid solution with piezoelectricity stronger than lead zirconate titanate 期刊论文
SCIENCE, 2019, 363 (6432) : 1206-+
作者:  Liao, Wei-Qiang;  Zhao, Dewei;  Tang, Yuan-Yuan;  Zhang, Yi;  Li, Peng-Fei;  Shi, Ping-Ping;  Chen, Xiao-Gang;  You, Yu-Meng;  Xiong, Ren-Gen
收藏  |  浏览/下载:16/0  |  提交时间:2019/11/27
Foliar morphology and spatial distribution in five-year-old plantations of Betula alnoides 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 432: 514-521
作者:  Wang, Chun-sheng;  Guo, Jun-jie;  Hein, Sebastian;  Wang, Huan;  Zhao, Zhi-gang;  Zeng, Jie
收藏  |  浏览/下载:14/0  |  提交时间:2019/04/09
Betula alnoides  Crown structure  Leaf morphology traits  Leaf vertical distribution  Planting density  Specific leaf area  
Method to Estimate Water Vapor Supersaturation in the Ambient Activation Process Using Aerosol and Droplet Measurement Data 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (18) : 10606-10619
作者:  Shen, Chuanyang;  Zhao, Chunsheng;  Ma, Nan;  Tao, Jiangchuan;  Zhao, Gang;  Yu, Yingli;  Kuang, Ye
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
supersaturation  aerosol  activation  cloud  fog  
The multidecadal variations of the interannual relationship between the East Asian summer monsoon and ENSO in a coupled model 期刊论文
CLIMATE DYNAMICS, 2018, 51: 1671-1686
作者:  Liu, Bo;  Huang, Gang;  Hu, Kaiming;  Wu, Renguang;  Gong, Hainan;  Wang, Pengfei;  Zhao, Guijie
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
East Asian Summer monsoon  ENSO  Coupled climate model  Interannual  Multidecadal variations  
Automatic Correction of Contaminated Images for Assessment of Reservoir Surface Area Dynamics 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (12) : 6092-6099
作者:  Zhao, Gang;  Gao, Huilin
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Landsat  reservoir area  contamination  image enhancement  Google Earth Engine  
Drop Size Distribution Characteristics of Seven Typhoons in China 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (12) : 6529-6548
作者:  Wen, Long;  Zhao, Kun;  Chen, Gang;  Wang, Mingjun;  Zhou, Bowen;  Huang, Hao;  Hu, Dongming;  Lee, Wen-Chau;  Hu, Hanfeng
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
drop size distribution  typhoon  China  microphysical characteristics  precipitation