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Warming-induced unprecedented high-elevation forest growth over the monsoonal Tibetan Plateau 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (5)
作者:  Shi, Chunming;  Schneider, Lea;  Hu, Yuan;  Shen, Miaogen;  Sun, Cheng;  Xia, Jianyang;  Forbes, Bruce C.;  Shi, Peili;  Zhang, Yuandong;  Ciais, Philippe
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Tibetan Plateau  high-elevation forest  growth  drought stress  warming  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Meridional Heat Transport During Atmospheric Rivers in High-Resolution CESM Climate Projections 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Shields, Christine A.;  Rosenbloom, Nan;  Bates, Susan C.;  Hannay, Cecile;  Hu, Aixue;  Payne, Ashley Elizabeth;  Rutz, Jonathan J.;  Truesdale, John
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
atmospheric rivers  heat transport  CESM high-resolution model  ARTMIP  
Polarimetric Radar Convective Cell Tracking Reveals Large Sensitivity of Cloud Precipitation and Electrification Properties to CCN 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (22) : 12194-12205
作者:  Hu, Jiaxi;  Rosenfeld, Daniel;  Ryzhkov, Alexander;  Zrnic, Dusan;  Williams, Earle;  Zhang, Pengfei;  Snyder, Jeffrey C.;  Zhang, Renyi;  Weitz, Richard
收藏  |  浏览/下载:7/0  |  提交时间:2020/02/17
aerosol-cloud interactions  cloud electrification  weather modification  
Synoptic Features Responsible for Heat Waves in Central Africa, a Region with Strong Multidecadal Trends 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (22) : 7951-7970
作者:  Hu, Lisuo;  Luo, Jing-Jia;  Huang, Gang;  Wheeler, Matthew C.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Atmosphere  Africa  Atmospheric circulation  Extreme events  Temperature  Anomalies  
On the Delayed Coupling Between Ocean and Atmosphere in Recent Weak El Nino Episodes 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Johnson, N. C.;  Heureux, M. L. L.;  Chang, C-H;  Hu, Z-Z
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
El Nino  tropical convection  Walker circulation  
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Jiang, Xi;  Hu, Chao;  Ferchen, Kyle;  Nie, Ji;  Cui, Xiaolong;  Chen, Chih-Hong;  Cheng, Liting;  Zuo, Zhixiang;  Seibel, William;  He, Chunjiang;  Tang, Yixuan;  Skibbe, Jennifer R.;  Wunderlich, Mark;  Reinhold, William C.;  Dong, Lei;  Shen, Chao;  Arnovitz, Stephen;  Ulrich, Bryan;  Lu, Jiuwei;  Weng, Hengyou;  Su, Rui;  Huang, Huilin;  Wang, Yungui;  Li, Chenying;  Qin, Xi;  Mulloy, James;  Zheng, Yi;  Diao, Jiajie;  Jin, Jie;  Li, Chong;  Liu, Paul P.;  He, Chuan;  Chen, Yuan;  Chen, Jianjun
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
Tracking and characterization of convective cells through their maturation into stratiform storm elements using polarimetric radar and lightning detection 期刊论文
ATMOSPHERIC RESEARCH, 2019, 226: 192-207
作者:  Hu, Jiaxi;  Rosenfeld, Daniel;  Zrnic, Dusan;  Williams, Earle;  Zhang, Pengfei;  Snyder, Jeffrey C.;  Ryzhkov, Alexander;  Hashimshoni, Eyal;  Zhang, Renyi;  Weitz, Richard
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Cloud tracking  Cloud microphysics  Radar observation  
Network parameters quantify loss of assemblage structure in human-impacted lake ecosystems 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (11) : 3871-3882
作者:  Wang, Rong;  Dearing, John A.;  Doncaster, C. Patrick;  Yang, Xiangdong;  Zhang, Enlou;  Langdon, Peter G.;  Yang, Hui;  Dobg, Xuhui;  Hu, Zhujun;  Xu, Min;  Zhao, Yanjie;  Shen, Ji
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
biodiversity  diatom assemblages  ecological resilience  network skewness  self-organized system  stability