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Improved 1 km resolution PM2.5 estimates across China using enhanced space-time extremely randomized trees 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 3273-3289
作者:  Wei, Jing;  Li, Zhanqing;  Cribb, Maureen;  Huang, Wei;  Xue, Wenhao;  Sun, Lin;  Guo, Jianping;  Peng, Yiran;  Li, Jing;  Lyapustin, Alexei;  Liu, Lei;  Wu, Hao;  Song, Yimeng
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/02
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Contrasting size-resolved hygroscopicity of fine particles derived by HTDMA and HR-ToF-AMS measurements between summer and winter in Beijing: the impacts of aerosol aging and local emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 915-929
作者:  Fan, Xinxin;  Liu, Jieyao;  Zhang, Fang;  Chen, Lu;  Collins, Don;  Xu, Weiqi;  Jin, Xiaoai;  Ren, Jingye;  Wang, Yuying;  Wu, Hao;  Li, Shangze;  Sun, Yele;  Li, Zhanqing
收藏  |  浏览/下载：8/0  |  提交时间：2020/07/02
Significant contribution of organics to aerosol liquid water content in winter in Beijing, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 901-914
作者:  Jin, Xiaoai;  Wang, Yuying;  Li, Zhanqing;  Zhang, Fang;  Xu, Weiqi;  Sun, Yele;  Fan, Xinxin;  Chen, Guangyu;  Wu, Hao;  Ren, Jingye;  Wang, Qiuyan;  Cribb, Maureen
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/02
Importance of Bias Correction in Data Assimilation of Multiple Observations Over Eastern China Using WRF-Chem/DART 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (1)
作者:  Ma, Chaoqun;  Wang, Tijian;  Jiang, Ziqiang;  Wu, Hao;  Zhao, Ming;  Zhuang, Bingliang;  Li, Shu;  Xie, Min;  Li, Mengmeng;  Liu, Jane;  Wu, Rongsheng
收藏  |  浏览/下载：13/0  |  提交时间：2020/07/02
Significantly Enhanced Aerosol CCN Activity and Number Concentrations by Nucleation-Initiated Haze Events: A Case Study in Urban Beijing 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (24) : 14102-14113
作者:  Zhang, Fang;  Ren, Jingye;  Fan, Tianyi;  Chen, Lu;  Xu, Weiqi;  Sun, Yele;  Zhang, Renyi;  Liu, Jieyao;  Jiang, Sihui;  Jin, Xiaoai;  Wu, Hao;  Li, Shangze;  Cribb, Maureen C.;  Li, Zhanqing
收藏  |  浏览/下载：13/0  |  提交时间：2020/02/17
How transit scaling shapes cities 期刊论文
NATURE SUSTAINABILITY, 2019, 2 (12) : 1142-1148
作者:  Wu, Hao;  Levinson, David;  Sarkar, Somwrita
收藏  |  浏览/下载：2/0  |  提交时间：2020/02/16
Structure of the RSC complex bound to the nucleosome 期刊论文
SCIENCE, 2019, 366 (6467) : 838-+
作者:  Ye, Youpi;  Wu, Hao;  Chen, Kangjing;  Clapier, Cedric R.;  Verma, Naveen;  Zhang, Wenhao;  Deng, Haiteng;  Cairns, Bradley R.;  Gao, Ning;  Chen, Zhucheng
收藏  |  浏览/下载：11/0  |  提交时间：2020/02/17
Distinct Ultrafine- and Accumulation-Mode Particle Properties in Clean and Polluted Urban Environments 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Wang, Yuying;  Li, Zhanqing;  Zhang, Renyi;  Jin, Xiaoai;  Xu, Weiqi;  Fan, Xinxin;  Wu, Hao;  Zhang, Fang;  Sun, Yele;  Wang, Qiuyan;  Cribb, Maureen;  Hu, Dawei
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
aerosol properties  aerosol hygroscopicity  H-TDMA  aerosol formation process  
Spatio-temporal dynamics of seedling communities are determined by seed input and habitat filtering in a subtropical montane forest 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 449
作者:  Xu, Yaozhan;  Wan, Dan;  Xiao, Zhiqiang;  Wu, Hao;  Jiang, Mingxi
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Species turnover  Species reordering  Species richness  Directional change  Habitat filtering  Forest dynamics plot