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Macroscopic somatic clonal expansion in morphologically normal human urothelium 期刊论文
Science, 2020
作者:  Ruoyan Li;  Yiqing Du;  Zhanghua Chen;  Deshu Xu;  Tianxin Lin;  Shanzhao Jin;  Gongwei Wang;  Ziyang Liu;  Min Lu;  Xu Chen;  Tao Xu;  Fan Bai
收藏  |  浏览/下载:9/0  |  提交时间:2020/10/12
An orally available non-nucleotide STING agonist with antitumor activity 期刊论文
Science, 2020
作者:  Bo-Sheng Pan;  Samanthi A. Perera;  Jennifer A. Piesvaux;  Jeremy P. Presland;  Gottfried K. Schroeder;  Jared N. Cumming;  B. Wesley Trotter;  Michael D. Altman;  Alexei V. Buevich;  Brandon Cash;  Saso Cemerski;  Wonsuk Chang;  Yiping Chen;  Peter J. Dandliker;  Guo Feng;  Andrew Haidle;  Timothy Henderson;  James Jewell;  Ilona Kariv;  Ian Knemeyer;  Johnny Kopinja;  Brian M. Lacey;  Jason Laskey;  Charles A. Lesburg;  Rui Liang;  Brian J. Long;  Min Lu;  Yanhong Ma;  Ellen C. Minnihan;  Greg O’Donnell;  Ryan Otte;  Laura Price;  Larissa Rakhilina;  Berengere Sauvagnat;  Sharad Sharma;  Sriram Tyagarajan;  Hyun Woo;  Daniel F. Wyss;  Serena Xu;  David Jonathan Bennett;  George H. Addona
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/25
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail 期刊论文
Science, 2020
作者:  Johanna Hansen;  Alina Baum;  Kristen E. Pascal;  Vincenzo Russo;  Stephanie Giordano;  Elzbieta Wloga;  Benjamin O. Fulton;  Ying Yan;  Katrina Koon;  Krunal Patel;  Kyung Min Chung;  Aynur Hermann;  Erica Ullman;  Jonathan Cruz;  Ashique Rafique;  Tammy Huang;  Jeanette Fairhurst;  Christen Libertiny;  Marine Malbec;  Wen-yi Lee;  Richard Welsh;  Glen Farr;  Seth Pennington;  Dipali Deshpande;  Jemmie Cheng;  Anke Watty;  Pascal Bouffard;  Robert Babb;  Natasha Levenkova;  Calvin Chen;  Bojie Zhang;  Annabel Romero Hernandez;  Kei Saotome;  Yi Zhou;  Matthew Franklin;  Sumathi Sivapalasingam;  David Chien Lye;  Stuart Weston;  James Logue;  Robert Haupt;  Matthew Frieman;  Gang Chen;  William Olson;  Andrew J. Murphy;  Neil Stahl;  George D. Yancopoulos;  Christos A. Kyratsous
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/25
Allele-specific open chromatin in human iPSC neurons elucidates functional disease variants 期刊论文
Science, 2020
作者:  Siwei Zhang;  Hanwen Zhang;  Yifan Zhou;  Min Qiao;  Siming Zhao;  Alena Kozlova;  Jianxin Shi;  Alan R. Sanders;  Gao Wang;  Kaixuan Luo;  Subhajit Sengupta;  Siobhan West;  Sheng Qian;  Michael Streit;  Dimitrios Avramopoulos;  Chad A. Cowan;  Mengjie Chen;  Zhiping P. Pang;  Pablo V. Gejman;  Xin He;  Jubao Duan
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/09
Exceptional plasticity in the bulk single-crystalline van der Waals semiconductor InSe 期刊论文
Science, 2020
作者:  Tian-Ran Wei;  Min Jin;  Yuecun Wang;  Hongyi Chen;  Zhiqiang Gao;  Kunpeng Zhao;  Pengfei Qiu;  Zhiwei Shan;  Jun Jiang;  Rongbin Li;  Lidong Chen;  Jian He;  Xun Shi
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/09
Ancient DNA indicates human population shifts and admixture in northern and southern China 期刊论文
Science, 2020
作者:  Melinda A. Yang;  Xuechun Fan;  Bo Sun;  Chungyu Chen;  Jianfeng Lang;  Ying-Chin Ko;  Cheng-hwa Tsang;  Hunglin Chiu;  Tianyi Wang;  Qingchuan Bao;  Xiaohong Wu;  Mateja Hajdinjak;  Albert Min-Shan Ko;  Manyu Ding;  Peng Cao;  Ruowei Yang;  Feng Liu;  Birgit Nickel;  Qingyan Dai;  Xiaotian Feng;  Lizhao Zhang;  Chengkai Sun;  Chao Ning;  Wen Zeng;  Yongsheng Zhao;  Ming Zhang;  Xing Gao;  Yinqiu Cui;  David Reich;  Mark Stoneking;  Qiaomei Fu
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/21
Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat 期刊论文
Science, 2020
作者:  Hongwei Wang;  Silong Sun;  Wenyang Ge;  Lanfei Zhao;  Bingqian Hou;  Kai Wang;  Zhongfan Lyu;  Liyang Chen;  Shoushen Xu;  Jun Guo;  Min Li;  Peisen Su;  Xuefeng Li;  Guiping Wang;  Cunyao Bo;  Xiaojian Fang;  Wenwen Zhuang;  Xinxin Cheng;  Jianwen Wu;  Luhao Dong;  Wuying Chen;  Wen Li;  Guilian Xiao;  Jinxiao Zhao;  Yongchao Hao;  Ying Xu;  Yu Gao;  Wenjing Liu;  Yanhe Liu;  Huayan Yin;  Jiazhu Li;  Xiang Li;  Yan Zhao;  Xiaoqian Wang;  Fei Ni;  Xin Ma;  Anfei Li;  Steven S. Xu;  Guihua Bai;  Eviatar Nevo;  Caixia Gao;  Herbert Ohm;  Lingrang Kong
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/25
Injured adult neurons regress to an embryonic transcriptional growth state 期刊论文
NATURE, 2020, 581 (7806) : 77-+
作者:  Wang, Ruicong;  Li, Hongda;  Wu, Jianfeng;  Cai, Zhi-Yu;  Li, Baizhou;  Ni, Hengxiao;  Qiu, Xingfeng;  Chen, Hui;  Liu, Wei;  Yang, Zhang-Hua;  Liu, Min;  Hu, Jin;  Liang, Yaoji;  Lan, Ping;  Han, Jiahuai;  Mo, Wei
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration of corticospinal axons and restore forelimb function after spinal cord injury(1)  however, the molecular mechanisms that underlie this regeneration are unknown. Here we perform translational profiling specifically of corticospinal tract (CST) motor neurons in mice, to identify their '  regenerative transcriptome'  after spinal cord injury and NPC grafting. Notably, both injury alone and injury combined with NPC grafts elicit virtually identical early transcriptomic responses in host CST neurons. However, in mice with injury alone this regenerative transcriptome is downregulated after two weeks, whereas in NPC-grafted mice this transcriptome is sustained. The regenerative transcriptome represents a reversion to an embryonic transcriptional state of the CST neuron. The huntingtin gene (Htt) is a central hub in the regeneration transcriptome  deletion of Htt significantly attenuates regeneration, which shows that Htt has a key role in neural plasticity after injury.


In mouse models of central nervous system injury, Htt is shown to be a key component of the regulatory program associated with reversion of the neuronal transcriptome to a less-mature state.


  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).