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De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 期刊论文
Science, 2020
作者:  Thomas W. Linsky;  Renan Vergara;  Nuria Codina;  Jorgen W. Nelson;  Matthew J. Walker;  Wen Su;  Christopher O. Barnes;  Tien-Ying Hsiang;  Katharina Esser-Nobis;  Kevin Yu;  Z. Beau Reneer;  Yixuan J. Hou;  Tanu Priya;  Masaya Mitsumoto;  Avery Pong;  Uland Y. Lau;  Marsha L. Mason;  Jerry Chen;  Alex Chen;  Tania Berrocal;  Hong Peng;  Nicole S. Clairmont;  Javier Castellanos;  Yu-Ru Lin;  Anna Josephson-Day;  Ralph S. Baric;  Deborah H. Fuller;  Carl D. Walkey;  Ted M. Ross;  Ryan Swanson;  Pamela J. Bjorkman;  Michael Gale;  Luis M. Blancas-Mejia;  Hui-Ling Yen;  Daniel-Adriano Silva
收藏  |  浏览/下载:11/0  |  提交时间:2020/12/07
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity 期刊论文
Science, 2020
作者:  Ellen Shrock;  Eric Fujimura;  Tomasz Kula;  Richard T. Timms;  I-Hsiu Lee;  Yumei Leng;  Matthew L. Robinson;  Brandon M. Sie;  Mamie Z. Li;  Yuezhou Chen;  Jennifer Logue;  Adam Zuiani;  Denise McCulloch;  Felipe J. N. Lelis;  Stephanie Henson;  Daniel R. Monaco;  Meghan Travers;  Shaghayegh Habibi;  William A. Clarke;  Patrizio Caturegli;  Oliver Laeyendecker;  Alicja Piechocka-Trocha;  Jonathan Z. Li;  Ashok Khatri;  Helen Y. Chu;  MGH COVID-19 Collection &;  amp;  Processing Team16‡;  Alexandra-Chloé Villani;  Kyle Kays;  Marcia B. Goldberg;  Nir Hacohen;  Michael R. Filbin;  Xu G. Yu;  Bruce D. Walker;  Duane R. Wesemann;  H. Benjamin Larman;  James A. Lederer;  Stephen J. Elledge
收藏  |  浏览/下载:11/0  |  提交时间:2020/11/30
Andean drought and glacial retreat tied to Greenland warming during the last glacial period 期刊论文
Nature Communications, 2020
作者:  Arielle Woods;  Donald T. Rodbell;  Mark B. Abbott;  Robert G. Hatfield;  Christine Y. Chen;  Sophie B. Lehmann;  David McGee;  Nicholas C. Weidhaas;  Pedro M. Tapia;  Blas L. Valero-Garcé;  s;  Mark B. Bush;  Joseph S. Stoner
收藏  |  浏览/下载:5/0  |  提交时间:2020/10/20
Wrong-way migrations of benthic species driven by ocean warming and larval transport 期刊论文
Nature, 2020
作者:  Heidi L. Fuchs;  Robert J. Chant;  Elias J. Hunter;  Enrique N. Curchitser;  Gregory P. Gerbi;  Emily Y. Chen
收藏  |  浏览/下载:6/0  |  提交时间:2020/09/14
Proton transport enabled by a field-induced metallic state in a semiconductor heterostructure 期刊论文
Science, 2020
作者:  Y. Wu;  B. Zhu;  M. Huang;  L. Liu;  Q. Shi;  M. Akbar;  C. Chen;  J. Wei;  J. F. Li;  L. R. Zheng;  J. S. Kim;  H. B. Song
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/14
HBO1 is required for the maintenance of leukaemia stem cells 期刊论文
NATURE, 2020, 577 (7789) : 266-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  de Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Poh Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks of AML have progressed into clinical trials, but most show only modest efficacy owing to an inability to effectively eradicate leukaemia stem cells (LSCs)(1). Here, to specifically identify novel dependencies in LSCs, we screened a bespoke library of small hairpin RNAs that target chromatin regulators in a unique ex vivo mouse model of LSCs. We identify the MYST acetyltransferase HBO1 (also known as KAT7 or MYST2) and several known members of the HBO1 protein complex as critical regulators of LSC maintenance. Using CRISPR domain screening and quantitative mass spectrometry, we identified the histone acetyltransferase domain of HBO1 as being essential in the acetylation of histone H3 at K14. H3 acetylated at K14 (H3K14ac) facilitates the processivity of RNA polymerase II to maintain the high expression of key genes (including Hoxa9 and Hoxa10) that help to sustain the functional properties of LSCs. To leverage this dependency therapeutically, we developed a highly potent small-molecule inhibitor of HBO1 and demonstrate its mode of activity as a competitive analogue of acetyl-CoA. Inhibition of HBO1 phenocopied our genetic data and showed efficacy in a broad range of human cell lines and primary AML cells from patients. These biological, structural and chemical insights into a therapeutic target in AML will enable the clinical translation of these findings.


  
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome 期刊论文
NATURE, 2020
作者:  Coll, Anthony P.;  Chen, Michael;  Taskar, Pranali;  Rimmington, Debra;  Patel, Satish;  Tadross, John A.;  Cimino, Irene;  Yang, Ming;  Welsh, Paul;  Virtue, Samuel;  Goldspink, Deborah A.;  Miedzybrodzka, Emily L.;  Konopka, Adam R.;  Esponda, Raul Ruiz;  Huang, Jeffrey T. -J.;  Tung, Y. C. Loraine;  Rodriguez-Cuenca, Sergio
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

The cryo-electron microscopy structure of the 16-subunit yeast SWI/SNF complex RSC in complex with a nucleosome substrate provides insights into the chromatin-remodelling function of this family of protein complexes.


Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs)(1,2). In the yeast Saccharomyces cerevisiae, the essential SWI/SNF complex RSC3 contains 16 subunits, including the ATP-dependent DNA translocase Sth1(4,5). RSC removes nucleosomes from promoter regions(6,7) and positions the specialized +1 and -1 nucleosomes that flank NDRs(8,9). Here we present the cryo-electron microscopy structure of RSC in complex with a nucleosome substrate. The structure reveals that RSC forms five protein modules and suggests key features of the remodelling mechanism. The body module serves as a scaffold for the four flexible modules that we call DNA-interacting, ATPase, arm and actin-related protein (ARP) modules. The DNA-interacting module binds extra-nucleosomal DNA and is involved in the recognition of promoter DNA elements(8,10,11) that influence RSC functionality(12). The ATPase and arm modules sandwich the nucleosome disc with the Snf2 ATP-coupling (SnAC) domain and the finger helix, respectively. The translocase motor of the ATPase module engages with the edge of the nucleosome at superhelical location +2. The mobile ARP module may modulate translocase-nucleosome interactions to regulate RSC activity(5). The RSC-nucleosome structure provides a basis for understanding NDR formation and the structure and function of human SWI/SNF complexes that are frequently mutated in cancer(13).


  
Diurnal Variation of Meiyu Rainfall in the Yangtze Plain During Atypical Meiyu Years 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (1)
作者:  Zhang, A. Q.;  Chen, Y. L.;  Zhou, S. N.;  Cui, C. G.;  Wan, R.;  Fu, Y. F.
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/02
Signatures of self-organized criticality in an ultracold atomic gas 期刊论文
NATURE, 2020, 577 (7791) : 481-+
作者:  MacPherson, Laura;  Anokye, Juliana;  Yeung, Miriam M.;  Lam, Enid Y. N.;  Chan, Yih-Chih;  Weng, Chen-Fang;  Yeh, Paul;  Knezevic, Kathy;  Butler, Miriam S.;  Hoegl, Annabelle;  Chan, Kah-Lok;  Burr, Marian L.;  Gearing, Linden J.;  Willson, Tracy;  Liu, Joy;  Choi, Jarny;  Yang, Yuqing;  Bilardi, Rebecca A.;  Falk, Hendrik;  Nghi Nguyen;  Stupple, Paul A.;  Peat, Thomas S.;  Zhang, Ming;  De Silva, Melanie;  Carrasco-Pozo, Catalina;  Avery, Vicky M.;  Khoo, Sim;  Dolezal, Olan;  Dennis, Matthew L.;  Nuttall, Stewart;  Surjadi, Regina;  Newman, Janet;  Ren, Bin;  Leaver, David J.;  Sun, Yuxin;  Baell, Jonathan B.;  Dovey, Oliver;  Vassiliou, George S.;  Grebien, Florian;  Dawson, Sarah-Jane;  Street, Ian P.;  Monahan, Brendon J.;  Burns, Christopher J.;  Choudhary, Chunaram;  Blewitt, Marnie E.;  Voss, Anne K.;  Thomas, Tim;  Dawson, Mark A.
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

Self-organized criticality is an elegant explanation of how complex structures emerge and persist throughout nature(1), and why such structures often exhibit similar scale-invariant properties(2-9). Although self-organized criticality is sometimes captured by simple models that feature a critical point as an attractor for the dynamics(10-15), the connection to real-world systems is exceptionally hard to test quantitatively(16-21). Here we observe three key signatures of self-organized criticality in the dynamics of a driven-dissipative gas of ultracold potassium atoms: self-organization to a stationary state that is largely independent of the initial conditions  scale-invariance of the final density characterized by a unique scaling function  and large fluctuations of the number of excited atoms (avalanches) obeying a characteristic power-law distribution. This work establishes a well-controlled platform for investigating self-organization phenomena and non-equilibrium criticality, with experimental access to the underlying microscopic details of the system.


A driven-dissipative gas of ultracold potassium atoms is used to demonstrate three key signatures of self-organized criticality, and provides a system in which the phenomenon can be experimentally tested.