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Ancient genomes reveal tropical bovid species in the Tibetan Plateau contributed to the prevalence of hunting game until the late Neolithic 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Ningbo Chen;  Lele Ren;  Linyao Du;  Jiawen Hou;  Victoria E. Mullin;  Duo Wu;  Xueye Zhao;  Chunmei Li;  Jiahui Huang;  Xuebin Qi;  Marco Rosario Capodiferro;  Alessandro Achilli;  Chuzhao Lei;  Fahu Chen;  Bing Su;  Guanghui Dong;  Xiaoming Zhang
收藏  |  浏览/下载:11/0  |  提交时间:2020/10/26
Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults 期刊论文
Environmental Health Perspectives, 2020
作者:  Sebastian Rauschert;  Phillip E. Melton;  Anni Heiskala;  Ville Karhunen;  Graham Burdge;  Jeffrey M. Craig;  Keith M. Godfrey;  Karen Lillycrop;  Trevor A. Mori;  Lawrence J. Beilin;  Wendy H. Oddy;  Craig Pennell;  Marjo-Riitta Järvelin;  Sylvain Sebert;  Rae-Chi Huang
收藏  |  浏览/下载:7/0  |  提交时间:2020/09/22
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications 期刊论文
Science, 2020
作者:  Divij Mathew;  Josephine R. Giles;  Amy E. Baxter;  Derek A. Oldridge;  Allison R. Greenplate;  Jennifer E. Wu;  Cécile Alanio;  Leticia Kuri-Cervantes;  M. Betina Pampena;  Kurt D’Andrea;  Sasikanth Manne;  Zeyu Chen;  Yinghui Jane Huang;  John P. Reilly;  Ariel R. Weisman;  Caroline A. G. Ittner;  Oliva Kuthuru;  Jeanette Dougherty;  Kito Nzingha;  Nicholas Han;  Justin Kim;  Ajinkya Pattekar;  Eileen C. Goodwin;  Elizabeth M. Anderson;  Madison E. Weirick;  Sigrid Gouma;  Claudia P. Arevalo;  Marcus J. Bolton;  Fang Chen;  Simon F. Lacey;  Holly Ramage;  Sara Cherry;  Scott E. Hensley;  Sokratis A. Apostolidis;  Alexander C. Huang;  Laura A. Vella;  The UPenn COVID Processing Unit†;  Michael R. Betts;  Nuala J. Meyer;  E. John Wherry
收藏  |  浏览/下载:16/0  |  提交时间:2020/09/08
Spaceborne Mid‐ and Far‐infrared Observations Improving Nighttime Ice Cloud Property Retrievals 期刊论文
Geophysical Research Letters, 2020
作者:  Masanori Saito;  Ping Yang;  Xianglei Huang;  Helen E. Brindley;  Martin G. Mlynczak;  Brian H. Kahn
收藏  |  浏览/下载:10/0  |  提交时间:2020/09/08
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model 期刊论文
Science, 2020
作者:  Thomas F. Rogers;  Fangzhu Zhao;  Deli Huang;  Nathan Beutler;  Alison Burns;  Wan-ting He;  Oliver Limbo;  Chloe Smith;  Ge Song;  Jordan Woehl;  Linlin Yang;  Robert K. Abbott;  Sean Callaghan;  Elijah Garcia;  Jonathan Hurtado;  Mara Parren;  Linghang Peng;  Sydney Ramirez;  James Ricketts;  Michael J. Ricciardi;  Stephen A. Rawlings;  Nicholas C. Wu;  Meng Yuan;  Davey M. Smith;  David Nemazee;  John R. Teijaro;  James E. Voss;  Ian A. Wilson;  Raiees Andrabi;  Bryan Briney;  Elise Landais;  Devin Sok;  Joseph G. Jardine;  Dennis R. Burton
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/25
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail 期刊论文
Science, 2020
作者:  Johanna Hansen;  Alina Baum;  Kristen E. Pascal;  Vincenzo Russo;  Stephanie Giordano;  Elzbieta Wloga;  Benjamin O. Fulton;  Ying Yan;  Katrina Koon;  Krunal Patel;  Kyung Min Chung;  Aynur Hermann;  Erica Ullman;  Jonathan Cruz;  Ashique Rafique;  Tammy Huang;  Jeanette Fairhurst;  Christen Libertiny;  Marine Malbec;  Wen-yi Lee;  Richard Welsh;  Glen Farr;  Seth Pennington;  Dipali Deshpande;  Jemmie Cheng;  Anke Watty;  Pascal Bouffard;  Robert Babb;  Natasha Levenkova;  Calvin Chen;  Bojie Zhang;  Annabel Romero Hernandez;  Kei Saotome;  Yi Zhou;  Matthew Franklin;  Sumathi Sivapalasingam;  David Chien Lye;  Stuart Weston;  James Logue;  Robert Haupt;  Matthew Frieman;  Gang Chen;  William Olson;  Andrew J. Murphy;  Neil Stahl;  George D. Yancopoulos;  Christos A. Kyratsous
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/25
Broad neutralization of SARS-related viruses by human monoclonal antibodies 期刊论文
Science, 2020
作者:  Anna Z. Wec;  Daniel Wrapp;  Andrew S. Herbert;  Daniel P. Maurer;  Denise Haslwanter;  Mrunal Sakharkar;  Rohit K. Jangra;  M. Eugenia Dieterle;  Asparouh Lilov;  Deli Huang;  Longping V. Tse;  Nicole V. Johnson;  Ching-Lin Hsieh;  Nianshuang Wang;  Juergen H. Nett;  Elizabeth Champney;  Irina Burnina;  Michael Brown;  Shu Lin;  Melanie Sinclair;  Carl Johnson;  Sarat Pudi;  Robert Bortz;  Ariel S. Wirchnianski;  Ethan Laudermilch;  Catalina Florez;  J. Maximilian Fels;  Cecilia M. O’Brien;  Barney S. Graham;  David Nemazee;  Dennis R. Burton;  Ralph S. Baric;  James E. Voss;  Kartik Chandran;  John M. Dye;  Jason S. McLellan;  Laura M. Walker
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/18
Photoperiod and temperature as dominant environmental drivers triggering secondary growth resumption in Northern Hemisphere conifers 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Jian-Guo Huang;  Qianqian Ma;  Sergio Rossi;  Franco Biondi;  Annie Deslauriers;  Patrick Fonti;  Eryuan Liang;  Harri Mäkinen;  Walter Oberhuber;  Cyrille B. K. Rathgeber;  Roberto Tognetti;  Václav Treml;  Bao Yang;  Jiao-Lin Zhang;  Serena Antonucci;  Yves Bergeron;  J. Julio Camarero;  Filipe Campelo;  Katarina Čufar;  Henri E. Cuny;  Martin De Luis;  Alessio Giovannelli;  Jožica Gričar;  Andreas Gruber;  Vladimír Gryc;  Aylin Güney;  Xiali Guo;  Wei Huang;  Tuula Jyske;  Jakub Kašpar;  Gregory King;  Cornelia Krause;  Audrey Lemay;  Feng Liu;  Fabio Lombardi;  Edurne Martinez del Castillo;  Hubert Morin;  Cristina Nabais;  Pekka Nöjd;  Richard L. Peters;  Peter Prislan;  Antonio Saracino;  Irene Swidrak;  Hanuš Vavrčík;  Joana Vieira;  Biyun Yu;  Shaokang Zhang;  Qiao Zeng;  Yaling Zhang;  Emanuele Ziaco
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/18
HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease 期刊论文
Science, 2020
作者:  Sarah A. Cook;  William A. Comrie;  M. Cecilia Poli;  Morgan Similuk;  Andrew J. Oler;  Aiman J. Faruqi;  Douglas B. Kuhns;  Sheng Yang;  Alexander Vargas-Hernández;  Alexandre F. Carisey;  Benjamin Fournier;  D. Eric Anderson;  Susan Price;  Margery Smelkinson;  Wadih Abou Chahla;  Lisa R. Forbes;  Emily M. Mace;  Tram N. Cao;  Zeynep H. Coban-Akdemir;  Shalini N. Jhangiani;  Donna M. Muzny;  Richard A. Gibbs;  James R. Lupski;  Jordan S. Orange;  Geoffrey D. E. Cuvelier;  Moza Al Hassani;  Nawal Al Kaabi;  Zain Al Yafei;  Soma Jyonouchi;  Nikita Raje;  Jason W. Caldwell;  Yanping Huang;  Janis K. Burkhardt;  Sylvain Latour;  Baoyu Chen;  Gehad ElGhazali;  V. Koneti Rao;  Ivan K. Chinn;  Michael J. Lenardo
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/14
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.