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Selection enhances protein evolvability by increasing mutational robustness and foldability 期刊论文
Science, 2020
作者:  Jia Zheng;  Ning Guo;  Andreas Wagner
收藏  |  浏览/下载:7/0  |  提交时间:2020/12/07
The quest for improved air quality may push China to continue its CO2 reduction beyond the Paris Commitment 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Jia Xing;  Xi Lu;  Shuxiao Wang;  Tong Wang;  Dian Ding;  Sha Yu;  Drew Shindell;  Yang Ou;  Lidia Morawska;  Siwei Li;  Lu Ren;  Yuqiang Zhang;  Dan Loughlin;  Haotian Zheng;  Bin Zhao;  Shuchang Liu;  Kirk R. Smith;  Jiming Hao
收藏  |  浏览/下载:17/0  |  提交时间:2020/11/20
Role of export industries on ozone pollution and its precursors in China 期刊论文
Nature Communications, 2020
作者:  Jiamin Ou;  Zhijiong Huang;  Zbigniew Klimont;  Guanglin Jia;  Shaohui Zhang;  Cheng Li;  Jing Meng;  Zhifu Mi;  Heran Zheng;  Yuli Shan;  Peter K. K. Louie;  Junyu Zheng;  Dabo Guan
收藏  |  浏览/下载:19/0  |  提交时间:2020/11/09
Chemical‐Mechanical Impacts of CO2 Intrusion into Heterogeneous Caprock 期刊论文
Water Resources Research, 2020
作者:  Ting Xiao;  Hao Xu;  Nathan Moodie;  Richard Esser;  Wei Jia;  Liange Zheng;  Jonny Rutqvist;  Brian McPherson
收藏  |  浏览/下载:5/0  |  提交时间:2020/09/22
Progressive nitrogen limitation across the Tibetan alpine permafrost region 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Kou, Dan;  Yang, Guibiao;  Li, Fei;  Feng, Xuehui;  Zhang, Dianye;  Mao, Chao;  Zhang, Qiwen;  Peng, Yunfeng;  Ji, Chengjun;  Zhu, Qiuan;  Fang, Yunting;  Liu, Xueyan;  Xu-Ri;  Li, Siqi;  Deng, Jia;  Zheng, Xunhua;  Fang, Jingyun;  Yang, Yuanhe
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/06
Improvement of snow/haze confusion data gaps in MODIS Dark Target aerosol retrievals in East China 期刊论文
Atmospheric Research, 2020
作者:  Xiao Zhang, Hong Wang, Hui-Zheng Che, Sai-Chun Tan, ... Hu-Jia Zhao
收藏  |  浏览/下载:11/0  |  提交时间:2020/06/01
Sources of nitrous acid (HONO) in the upper boundary layer and lower free troposphere of North China Plain: insights from the Mount Tai Observatory 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Ying Jiang, Likun Xue, Rongrong Gu, Mengwei Jia, Yingnan Zhang, Liang Wen, Penggang Zheng, Tianshu Chen, Hongyong Li, Ye Shan, Yong Zhao, Zhaoxin Guo, Yujian Bi, Hengde Liu, Aijun Ding, Qingzhu Zhang, and Wenxing Wang
收藏  |  浏览/下载:12/0  |  提交时间:2020/06/01
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:25/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
CRISPR screen in regulatory T cells reveals modulators of Foxp3 期刊论文
NATURE, 2020
作者:  Xu, Daqian;  Wang, Zheng;  Xia, Yan;  Shao, Fei;  Xia, Weiya;  Wei, Yongkun;  Li, Xinjian;  Qian, Xu;  Lee, Jong-Ho;  Du, Linyong;  Zheng, Yanhua;  Lv, Guishuai;  Leu, Jia-shiun;  Wang, Hongyang;  Xing, Dongming;  Liang, Tingbo;  Hung, Mien-Chie;  Lu, Zhimin
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

Regulatory T (T-reg) cells are required to control immune responses and maintain homeostasis, but are a significant barrier to antitumour immunity(1). Conversely, T-reg instability, characterized by loss of the master transcription factor Foxp3 and acquisition of proinflammatory properties(2), can promote autoimmunity and/or facilitate more effective tumour immunity(3,4). A comprehensive understanding of the pathways that regulate Foxp3 could lead to more effective T-reg therapies for autoimmune disease and cancer. The availability of new functional genetic tools has enabled the possibility of systematic dissection of the gene regulatory programs that modulate Foxp3 expression. Here we developed a CRISPR-based pooled screening platform for phenotypes in primary mouse T-reg cells and applied this technology to perform a targeted loss-of-function screen of around 500 nuclear factors to identify gene regulatory programs that promote or disrupt Foxp3 expression. We identified several modulators of Foxp3 expression, including ubiquitin-specific peptidase 22 (Usp22) and ring finger protein 20 (Rnf20). Usp22, a member of the deubiquitination module of the SAGA chromatin-modifying complex, was revealed to be a positive regulator that stabilized Foxp3 expression  whereas the screen suggested that Rnf20, an E3 ubiquitin ligase, can serve as a negative regulator of Foxp3. T-reg-specific ablation of Usp22 in mice reduced Foxp3 protein levels and caused defects in their suppressive function that led to spontaneous autoimmunity but protected against tumour growth in multiple cancer models. Foxp3 destabilization in Usp22-deficient T-reg cells could be rescued by ablation of Rnf20, revealing a reciprocal ubiquitin switch in T-reg cells. These results reveal previously unknown modulators of Foxp3 and demonstrate a screening method that can be broadly applied to discover new targets for T-reg immunotherapies for cancer and autoimmune disease.


A CRISPR-based screening platform was used to identify previously uncharacterized genes that regulate the regulatory T cell-specific master transcription factor Foxp3, indicating that this screening method may be broadly applicable for the discovery of other genes involved in autoimmunity and immune responses to cancer.


  
Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins 期刊论文
NATURE, 2020, 583 (7815) : 282-+
作者:  Li, Jia;  Yang, Xiangdong;  Liu, Yang;  Huang, Bolong;  Wu, Ruixia;  Zhang, Zhengwei;  Zhao, Bei;  Ma, Huifang;  Dang, Weiqi;  Wei, Zheng;  Wang, Kai;  Lin, Zhaoyang;  Yan, Xingxu;  Sun, Mingzi;  Li, Bo;  Pan, Xiaoqing;  Luo, Jun;  Zhang, Guangyu;  Liu, Yuan;  Huang, Yu;  Duan, Xidong;  Duan, Xiangfeng
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2(1). This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale of wild animals may be the source of zoonotic infection(2).Although bats are probable reservoir hosts for SARS-CoV-2, the identity of any intermediate host that may have facilitated transfer to humans is unknown. Here we report the identification of SARS-CoV-2-related coronaviruses in Malayan pangolins (Manisjavanica) seized in anti-smuggling operations in southern China. Metagenomic sequencing identified pangolin-associated coronaviruses that belong to two sub-lineages of SARS-CoV-2-related coronaviruses, including one that exhibits strong similarity in the receptor-binding domain to SARS-CoV-2. The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.