GSTDTAP

浏览/检索结果: 共30条,第1-10条 帮助

限定条件                    
已选(0)清除 条数/页:   排序方式:
Fast sulfate formation from oxidation of SO2 by NO2 and HONO observed in Beijing haze 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wang, Junfeng;  Li, Jingyi;  Ye, Jianhuai;  Zhao, Jian;  Wu, Yangzhou;  Hu, Jianlin;  Liu, Dantong;  Nie, Dongyang;  Shen, Fuzhen;  Huang, Xiangpeng;  Huang, Dan Dan;  Ji, Dongsheng;  Sun, Xu;  Xu, Weiqi;  Guo, Jianping;  Song, Shaojie;  Qin, Yiming;  Liu, Pengfei;  Turner, Jay R.;  Lee, Hyun Chul;  Hwang, Sungwoo;  Liao, Hong;  Martin, Scot T.;  Zhang, Qi;  Chen, Mindong;  Sun, Yele;  Ge, Xinlei;  Jacob, Daniel J.
收藏  |  浏览/下载:18/0  |  提交时间:2020/06/09
Nitrifier adaptation to low energy flux controls inventory of reduced nitrogen in the dark ocean 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (9) : 4823-4830
作者:  Zhang, Yao;  Qin, Wei;  Hou, Lei;  Zakem, Emily J.;  Wan, Xianhui;  Zhao, Zihao;  Liu, Li;  Hunt, Kristopher A.;  Jiao, Nianzhi;  Kao, Shuh-Ji;  Tang, Kai;  Xie, Xiabing;  Shen, Jiaming;  Li, Yufang;  Chen, Mingming;  Dai, Xiaofeng;  Liu, Chang;  Deng, Wenchao;  Dai, Minhan;  Ingalls, Anitra E.;  Stahl, David A.;  Herndl, Gerhard J.
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
nitrification  dark ocean  nitrogen flux  carbon fixation  homeostasis  
Global warming accelerates uptake of atmospheric mercury in regions experiencing glacier retreat 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (4) : 2049-2055
作者:  Wang, Xun;  Luo, Ji;  Yuan, Wei;  Lin, Che-Jen;  Wang, Feiyue;  Liu, Chen;  Wang, Genxu;  Feng, Xinbin
收藏  |  浏览/下载:7/0  |  提交时间:2020/05/13
global warming  glacier retreat  atmospheric mercury deposition  
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:143/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing 期刊论文
SCIENCE, 2019, 366 (6464) : 460-+
作者:  Lu, Yan;  Zheng, Yuping;  Coyaud, Etienne;  Zhang, Chao;  Selvabaskaran, Apiraam;  Yu, Yuyun;  Xu, Zizhen;  Weng, Xialian;  Chen, Ji Shun;  Meng, Ying;  Warner, Neil;  Cheng, Xiawei;  Liu, Yangyang;  Yao, Bingpeng;  Hu, Hu;  Xia, Zonping;  Muise, Aleixo M.;  Klip, Amira;  Brumell, John H.;  Girardin, Stephen E.;  Ying, Songmin;  Fairn, Gregory D.;  Raught, Brian;  Sun, Qiming;  Neculai, Dante
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Shi, Yulin;  Fan, Songqing;  Wu, Mengge;  Zuo, Zhixiang;  Li, Xingyang;  Jiang, Liping;  Shen, Qiushuo;  Xu, Peifang;  Zeng, Lin;  Zhou, Yongchun;  Huang, Yunchao;  Yang, Zuozhang;  Zhou, Jumin;  Gao, Jing;  Zhou, Hu;  Xu, Shuhua;  Ji, Hongbin;  Shi, Peng;  Wu, Dong-Dong;  Yang, Cuiping;  Chen, Yongbin
收藏  |  浏览/下载:21/0  |  提交时间:2019/11/27
MAIT cells are imprinted by the microbiota in early life and promote tissue repair 期刊论文
SCIENCE, 2019, 366 (6464) : 445-+
作者:  Constantinides, Michael G.;  Link, Verena M.;  Tamoutounour, Samira;  Wong, Andrea C.;  Perez-Chaparro, P. Juliana;  Han, Seong-Ji;  Chen, Y. Erin;  Li, Kelin;  Farhat, Sepideh;  Weckel, Antonin;  Krishnamurthy, Siddharth R.;  Vujkovic-Cvijin, Ivan;  Linehan, Jonathan L.;  Bouladoux, Nicolas;  Merrill, E. Dean;  Roy, Sobhan;  Cua, Daniel J.;  Adams, Erin J.;  Bhandoola, Avinash;  Scharschmidt, Tiffany C.;  Aube, Jeffrey;  Fischbach, Michael A.;  Belkaid, Yasmine
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Qiu, Fang;  Tang, Ruqi;  Zuo, Xianbo;  Shi, Xingjuan;  Wei, Yiran;  Zheng, Xiaodong;  Dai, Yaping;  Gong, Yuhua;  Wang, Lan;  Xu, Ping;  Zhu, Xiang;  Wu, Jian;  Han, Chongxu;  Gao, Yueqiu;  Zhang, Kui;  Jiang, Yuzhang;  Zhou, Jianbo;  Shao, Youlin;  Hu, Zhigang;  Tian, Ye;  Zhang, Haiyan;  Dai, Na;  Liu, Lei;  Wu, Xudong;  Zhao, Weifeng;  Zhang, Xiaomin;  Zang, Zhidong;  Nie, Jinshan;  Sun, Weihao;  Zhao, Yi;  Mao, Yuan;  Jiang, Po;  Ji, Hualiang;  Dong, Qing;  Li, Junming;  Li, Zhenzhong;  Bai, Xinli;  Li, Li;  Lin, Maosong;  Dong, Ming;  Li, Jinxin;  Zhu, Ping;  Wang, Chan;  Zhang, Yanqiu;  Jiang, Peng;  Wang, Yujue;  Jawed, Rohil;  Xu, Jing;  Zhang, Yu;  Wang, Qixia;  Yang, Yue;  Yang, Fan;  Lian, Min;  Jiang, Xiang;  Xiao, Xiao;  Li, Yanmei;  Fang, Jingyuan;  Qiu, Dekai;  Zhu, Zhen;  Qiu, Hong;  Zhang, Jianqiong;  Tian, Wenyan;  Chen, Sufang;  Jiang, Ling;  Ji, Bing;  Li, Ping;  Chen, Guochang;  Wu, Tianxue;  Sun, Yan;  Yu, Jianjiang;  Tang, Huijun;  He, Michun;  Xia, Min;  Pei, Hao;  Huang, Lihua;  Qing, Zhuye;  Wu, Jianfang;  Huang, Qinghai;  Han, Junhai;  Xie, Wei;  Sun, Zhongsheng;  Guo, Jian;  He, Gengsheng;  Gershwin, M. Eric;  Lian, Zhexiong;  Liu, Xiang;  Seldin, Michael F.;  Liu, Xiangdong;  Chen, Weichang;  Ma, Xiong
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Differential soil fungus accumulation and density dependence of trees in a subtropical forest 期刊论文
SCIENCE, 2019, 366 (6461) : 124-+
作者:  Chen, Lei;  Swenson, Nathan G.;  Ji, Niuniu;  Mi, Xiangcheng;  Ren, Haibao;  Guo, Liangdong;  Ma, Keping
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27