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Cost, risk, and avoidance of inbreeding in a cooperatively breeding bird 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (27) : 15724-15730
作者:  Leedale, Amy E.;  Simeoni, Michelle;  Sharp, Stuart P.;  Green, Jonathan P.;  Slate, Jon;  Lachlan, Robert F.;  Robinson, Elva J. H.;  Hatchwell, Ben J.
收藏  |  浏览/下载:7/0  |  提交时间:2020/06/29
inbreeding  kin discrimination  cooperative breeder  mate choice  
Honey bee virus causes context-dependent changes in host social behavior 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10406-10413
作者:  Geffre, Amy C.;  Gernat, Tim;  Harwood, Gyan P.;  Jones, Beryl M.;  Gysi, Deisy Morselli;  Hamilton, Adam R.;  Bonning, Bryony C.;  Toth, Amy L.;  Robinson, Gene E.;  Dolezal, Adam G.
收藏  |  浏览/下载:6/0  |  提交时间:2020/05/13
honey bee  virus  host-pathogen evolution  pathogen manipulation  
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I 期刊论文
NATURE, 2020, 581 (7806) : 100-+
作者:  Waszak, Sebastian M.;  Robinson, Giles W.;  Gudenas, Brian L.;  Smith, Kyle S.;  Forget, Antoine;  Kojic, Marija;  Garcia-Lopez, Jesus;  Hadley, Jennifer;  Hamilton, Kayla V.;  Indersie, Emilie;  Buchhalter, Ivo;  Kerssemakers, Jules;  Jager, Natalie;  Sharma, Tanvi;  Rausch, Tobias;  Kool, Marcel;  Sturm, Dominik;  Jones, David T. W.;  Vasilyeva, Aksana;  Tatevossian, Ruth G.;  Neale, Geoffrey;  Lombard, Berangere;  Loew, Damarys;  Nakitandwe, Joy;  Rusch, Michael;  Bowers, Daniel C.;  Bendel, Anne;  Partap, Sonia;  Chintagumpala, Murali;  Crawford, John;  Gottardo, Nicholas G.;  Smith, Amy;  Dufour, Christelle;  Rutkowski, Stefan;  Eggen, Tone;  Wesenberg, Finn;  Kjaerheim, Kristina;  Feychting, Maria;  Lannering, Birgitta;  Schuz, Joachim;  Johansen, Christoffer;  Andersen, Tina V.;  Roosli, Martin;  Kuehni, Claudia E.;  Grotzer, Michael;  Remke, Marc;  Puget, Stephanie;  Pajtler, Kristian W.;  Milde, Till;  Witt, Olaf;  Ryzhova, Marina;  Korshunov, Andrey;  Orr, Brent A.;  Ellison, David W.;  Brugieres, Laurence;  Lichter, Peter;  Nichols, Kim E.;  Gajjar, Amar;  Wainwright, Brandon J.;  Ayrault, Olivier;  Korbel, Jan O.;  Northcott, Paul A.;  Pfister, Stefan M.
收藏  |  浏览/下载:39/0  |  提交时间:2020/07/03

Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion include impaired antigen presentation caused by mutations or loss of heterozygosity of the major histocompatibility complex class I (MHC-I), which has been implicated in resistance to immune checkpoint blockade (ICB) therapy(1-3). However, in pancreatic ductal adenocarcinoma (PDAC), which is resistant to most therapies including ICB4, mutations that cause loss of MHC-I are rarely found(5) despite the frequent downregulation of MHC-I expression(6-8). Here we show that, in PDAC, MHC-I molecules are selectively targeted for lysosomal degradation by an autophagy-dependent mechanism that involves the autophagy cargo receptor NBR1. PDAC cells display reduced expression of MHC-I at the cell surface and instead demonstrate predominant localization within autophagosomes and lysosomes. Notably, inhibition of autophagy restores surface levels of MHC-I and leads to improved antigen presentation, enhanced anti-tumour T cell responses and reduced tumour growth in syngeneic host mice. Accordingly, the anti-tumour effects of autophagy inhibition are reversed by depleting CD8(+) T cells or reducing surface expression of MHC-I. Inhibition of autophagy, either genetically or pharmacologically with chloroquine, synergizes with dual ICB therapy (anti-PD1 and anti-CTLA4 antibodies), and leads to an enhanced anti-tumour immune response. Our findings demonstrate a role for enhanced autophagy or lysosome function in immune evasion by selective targeting of MHC-I molecules for degradation, and provide a rationale for the combination of autophagy inhibition and dual ICB therapy as a therapeutic strategy against PDAC.


Inhibition of the autophagy-lysosome system upregulates surface expression of MHC class I proteins and enhances antigen presentation, and evokes a potent anti-tumour immune response that is mediated by CD8(+) T cells.


  
Rebuilding marine life 期刊论文
NATURE, 2020, 580 (7801) : 39-51
作者:  Carlos M. Duarte;  Susana Agusti;  Edward Barbier;  Gregory L. Britten;  Juan Carlos Castilla;  Jean-Pierre Gattuso;  Robinson W. Fulweiler;  Terry P. Hughes;  Nancy Knowlton;  Catherine E. Lovelock;  Heike K. Lotze;  Milica Predragovic;  Elvira Poloczanska;  Callum Roberts;  Boris Worm
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13

Sustainable Development Goal 14 of the United Nations aims to "conserve and sustainably use the oceans, seas and marine resources for sustainable development". Achieving this goal will require rebuilding the marine life-support systems that deliver the many benefits that society receives from a healthy ocean. Here we document the recovery of marine populations, habitats and ecosystems following past conservation interventions. Recovery rates across studies suggest that substantial recovery of the abundance, structure and function of marine life could be achieved by 2050, if major pressures-including climate change-are mitigated. Rebuilding marine life represents a doable Grand Challenge for humanity, an ethical obligation and a smart economic objective to achieve a sustainable future.


  
Importance of Indigenous Peoples' lands for the conservation of Intact Forest Landscapes 期刊论文
FRONTIERS IN ECOLOGY AND THE ENVIRONMENT, 2020, 18 (3) : 135-140
作者:  Fa, John E.;  Watson, James E. M.;  Leiper, Ian;  Potapov, Peter;  Evans, Tom D.;  Burgess, Neil D.;  Molnar, Zsolt;  Fernandez-Llamazares, Alvaro;  Duncan, Tom;  Wang, Stephanie;  Austin, Beau J.;  Jonas, Harry;  Robinson, Cathy J.;  Malmer, Pernilla;  Zander, Kerstin K.;  Jackson, Micha, V;  Ellis, Erle;  Brondizio, Eduardo S.;  Garnett, Stephen T.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
Spatial Characteristics Reveal the Reactive Transport of Radium Isotopes (Ra-224, Ra-223, and Ra-228) in an Intertidal Aquifer 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (12) : 10282-10302
作者:  Liu, Yi;  Jiao, Jiu Jimmy;  Mao, Rong;  Luo, Xin;  Liang, Wenzhao;  Robinson, Clare E.
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/16
radium isotopes  reactive transport  intertidal aquifer  submarine groundwater discharge (SGD)  subterranean estuary  
Combined Effect of Tides and Varying Inland Groundwater Input on Flow and Salinity Distribution in Unconfined Coastal Aquifers 期刊论文
WATER RESOURCES RESEARCH, 2019
作者:  Kuan, Woei Keong;  Xin, Pei;  Jin, Guangqiu;  Robinson, Clare E.;  Gibbes, Badin;  Li, Ling
收藏  |  浏览/下载:6/0  |  提交时间:2020/02/16
submarine groundwater discharge  subterranean estuary  coastal water quality  saltwater intrusion  oceanic oscillations  
Towards Integrating Evolution, Metabolism, and Climate Change Studies of Marine Ecosystems 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2019, 34 (11) : 1022-1033
作者:  Baltar, Federico;  Bayer, Barbara;  Bednarsek, Nina;  Deppeler, Stacy;  Escribano, Ruben;  Gonzalez, Carolina E.;  Hansman, Roberta L.;  Mishra, Rajani Kanta;  Moran, Mary Ann;  Repeta, Daniel J.;  Robinson, Carol;  Sintes, Eva;  Tamburini, Christian;  Valentin, Luis E.;  Herndl, Gerhard J.
收藏  |  浏览/下载:22/0  |  提交时间:2019/11/27
Mortality Risk and Fine Particulate Air Pollution in a Large, Representative Cohort of U.S. Adults (vol 127, 077007, 2019) 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2019, 127 (9)
作者:  Pope, C. Arden, III;  Lefler, Jacob S.;  Ezzati, Majid;  Higbee, Joshua D.;  Marshall, Julian D.;  Kim, Sun-Young;  Bechle, Matthew;  Gilliat, Kurtis S.;  Vernon, Spencer E.;  Robinson, Allen L.;  Burnett, Richard T.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Prenatal and Childhood Traffic-Related Air Pollution Exposure and Telomere Length in European Children: The HELIX Project 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2019, 127 (8)
作者:  Clemente, Diana B. P.;  Vrijheid, Martine;  Martens, Dries S.;  Bustamante, Mariona;  Chatzi, Leda;  Danileviciute, Asta;  de Castro, Montserrat;  Grazideviciene, Regina;  Gutzkow, Kristine B.;  Lepeule, Johanna;  Maitre, Lea;  McEachan, Rosie R. C.;  Robinson, Oliver;  Schwarze, Per E.;  Tamayo, Ibon;  Vafeiadi, Marina;  Wright, John;  Slama, Rimy;  Nieuwenhuijsen, Mark;  Nawrot, Tim S.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27