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Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Chemical Differences Between PM1 and PM2.5 in Highly Polluted Environment and Implications in Air Pollution Studies 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (5)
作者:  Sun, Yele;  He, Yao;  Kuang, Ye;  Xu, Wanyun;  Song, Shaojie;  Ma, Nan;  Tao, Jiangchuan;  Cheng, Peng;  Wu, Cheng;  Su, Hang;  Cheng, Yafang;  Xie, Conghui;  Chen, Chun;  Lei, Lu;  Qiu, Yanmei;  Fu, Pingqing;  Croteau, Philip;  Worsnop, Douglas R.
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/02
Thermodynamic and dynamic effects of increased moisture sources over the Tropical Indian Ocean in recent decades 期刊论文
CLIMATE DYNAMICS, 2019
作者:  Han, Zixuan;  Su, Tao;  Zhang, Qiong;  Wen, Qin;  Feng, Guolin
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Moisture source  Atmospheric moisture budget  Dynamic and thermodynamic mechanisms  Walker circulation  Land-sea thermal contrast  
Comment on "Revised paleoaltimetry data show low Tibetan Plateau elevation during the Eocene" 期刊论文
SCIENCE, 2019, 365 (6459)
作者:  Valdes, Paul J.;  Lin, Ding;  Farnsworth, Alex;  Spicer, Robert A.;  Li, Shi-Hu;  Tao, Su
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Assessment of actual evapotranspiration variability over global land derived from seven reanalysis datasets 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (6) : 2919-2932
作者:  Feng, Taichen;  Su, Tao;  Zhi, Rong;  Tu, Gang;  Ji, Fei
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26
actual evapotranspiration  global warming  potential evapotranspiration  reanalysis  
Framework of multidimensional macrobenthos biodiversity to evaluate ecological restoration in wetlands 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (5)
作者:  Li, Xiaoxiao;  Yang, Wei;  Sun, Tao;  Su, Liya
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/26
multidimensional index  macrobenthos biodiversity  ecological restoration  holistic biodiversity  genetic diversity  taxonomic diversity  functional diversity  
Convection Initiation Resulting From the Interaction Between a Quasi-Stationary Dryline and Intersecting Gust Fronts: A Case Study 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (5) : 2379-2396
作者:  Bai, Lanqiang;  Meng, Zhiyong;  Huang, Yipeng;  Zhang, Yunji;  Niu, Shuzhen;  Su, Tao
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26
convection initiation  dry line  gust front  squall line  cold vortex  China  
Changes in global monsoon precipitation and the related dynamic and thermodynamic mechanisms in recent decades 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (3) : 1490-1503
作者:  Han, Zixuan;  Su, Tao;  Huang, Bicheng;  Feng, Taichen;  Qu, Shulin;  Feng, Guolin
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
atmospheric moisture budget  dynamic and thermodynamic mechanisms  global summer monsoon precipitation  long-term trends  water vapour sources  
Estimation of economic losses from tropical cyclones in China at 1.5 degrees C and 2.0 degrees C warming using the regional climate model COSMO-CLM 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (2) : 724-737
作者:  Wen, Shanshan;  Wang, Yanjun;  Su, Buda;  Gao, Chao;  Chen, Xue;  Jiang, Tong;  Tao, Hui;  Fischer, Thomas;  Wang, Guojie;  Zhai, Jianqing
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
1.5 degrees C and 20 degrees C warming  China  economic loss  influential tropical cyclone