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Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
MODIS-observed variations of lake ice phenology in Xinjiang, China 期刊论文
CLIMATIC CHANGE, 2019
作者:  Cai, Yu;  Ke, Chang-Qing;  Yao, Guohui;  Shen, Xiaoyi
收藏  |  浏览/下载：8/0  |  提交时间：2020/02/17
Lake ice phenology  Climate change  Xinjiang  MODIS  
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation 期刊论文
SCIENCE, 2019, 366 (6464) : 475-+
作者:  Dong, Guohua;  Li, Suzhi;  Yao, Mouteng;  Zhou, Ziyao;  Zhang, Yong-Qiang;  Han, Xu;  Luo, Zhenlin;  Yao, Junxiang;  Peng, Bin;  Hu, Zhongqiang;  Huang, Houbing;  Jia, Tingting;  Li, Jiangyu;  Ren, Wei;  Ye, Zuo-Guang;  Ding, Xiangdong;  Sun, Jun;  Nan, Ce-Wen;  Chen, Long-Qing;  Li, Ju;  Liu, Ming
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Ultrahigh-energy density lead-free dielectric films via polymorphic nanodomain design 期刊论文
SCIENCE, 2019, 365 (6453) : 578-582
作者:  Pan, Hao;  Li, Fei;  Liu, Yao;  Zhang, Qinghua;  Wang, Meng;  Lan, Shun;  Zheng, Yunpeng;  Ma, Jing;  Gu, Lin;  Shen, Yang;  Yu, Pu;  Zhang, Shujun;  Chen, Long-Qing;  Lin, Yuan-Hua;  Nan, Ce-Wen
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
Duration, spatial size and radiance of lightning flashes over the Asia-Pacific region based on TRMM/LIS observations 期刊论文
ATMOSPHERIC RESEARCH, 2019, 223: 98-113
作者:  You, Jin;  Zheng, Dong;  Zhang, Yijun;  Yao, Wen;  Meng, Qing
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Flash duration  Flash spatial size  Flash radiance  TRMM/LIS  
VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma 期刊论文
SCIENCE, 2018, 361 (6399) : 290-295
作者:  Zhang, Jing;  Wu, Tao;  Simon, Jeremy;  Takada, Mamoru;  Saito, Ryoichi;  Fan, Cheng;  Liu, Xian-De;  Jonasch, Eric;  Xie, Ling;  Chen, Xian;  Yao, Xiaosai;  Teh, Bin Tean;  Tan, Patrick;  Zheng, Xingnan;  Li, Mingjie;  Lawrence, Cortney;  Fan, Jie;  Geng, Jiang;  Liu, Xijuan;  Hu, Lianxin;  Wang, Jun;  Liao, Chengheng;  Hong, Kai;  Zurlo, Giada;  Parker, Joel S.;  Auman, J. Todd;  Perou, Charles M.;  Rathmell, W. Kimryn;  Kim, William Y.;  Kirschner, Marc W.;  Kaelin, William G., Jr.;  Baldwin, Albert S.;  Zhang, Qing
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Aerosol chemical compositions in the North China Plain and the impact on the visibility in Beijing and Tianjin 期刊论文
ATMOSPHERIC RESEARCH, 2018, 201: 235-246
作者:  Zou, Jianan;  Liu, Zirui;  Hu, Bo;  Huang, Xiaojuan;  Wen, Tianxue;  Ji, Dongsheng;  Liu, Jingyun;  Yang, Yang;  Yao, Qing;  Wang, Yuesi
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Aerosol chemical composition  Light extinction coefficients  Visibility  North China Plain  IMPROVE  
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly 期刊论文
SCIENCE, 2017, 358 (6365) : 933-+
作者:  Yuan, Ling;  Huang, Xing-Yao;  Liu, Zhong-Yu;  Zhang, Feng;  Zhu, Xing-Liang;  Yu, Jiu-Yang;  Ji, Xue;  Xu, Yan-Peng;  Li, Guanghui;  Li, Cui;  Wang, Hong-Jiang;  Deng, Yong-Qiang;  Wu, Menghua;  Cheng, Meng-Li;  Ye, Qing;  Xie, Dong-Yang;  Li, Xiao-Feng;  Wang, Xiangxi;  Shi, Weifeng;  Hu, Baoyang;  Shi, Pei-Yong;  Xu, Zhiheng;  Qin, Cheng-Feng
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
The role of fog in haze episode in Tianjin, China: A case study for November 2015 期刊论文
ATMOSPHERIC RESEARCH, 2017, 194
作者:  Hao, Tianyi;  Han, Suqin;  Chen, Shucheng;  Shan, Xiaolin;  Zai, Ziying;  Qiu, Xiaobin;  Yao, Qing;  Liu, Jingle;  Chen, Jing;  Meng, Lihong
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
Tianjin  Haze  Fog  Turbulence  Dissipation mechanism  
Response to Comment on "Molecular and neural basis of contagious itch behavior in mice" 期刊论文
SCIENCE, 2017, 357 (6347)
作者:  Barry, Devin M.;  Yu, Yao-Qing;  Hao, Yan;  Liu, Xue-Ting;  Chen, Zhou-Feng
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/27