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Self-assembled iron-containing mordenite monolith for carbon dioxide sieving 期刊论文
Science, 2021
作者:  Yu Zhou;  Jianlin Zhang;  Lei Wang;  Xili Cui;  Xiaoling Liu;  Sie Shing Wong;  Hua An;  Ning Yan;  Jingyan Xie;  Cong Yu;  Peixin Zhang;  Yonghua Du;  Shibo Xi;  Lirong Zheng;  Xingzhong Cao;  Yajing Wu;  Yingxia Wang;  Chongqing Wang;  Haimeng Wen;  Lei Chen;  Huabin Xing;  Jun Wang
收藏  |  浏览/下载:23/0  |  提交时间:2021/07/27
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors 期刊论文
Science, 2020
作者:  Longxing Cao;  Inna Goreshnik;  Brian Coventry;  James Brett Case;  Lauren Miller;  Lisa Kozodoy;  Rita E. Chen;  Lauren Carter;  Alexandra C. Walls;  Young-Jun Park;  Eva-Maria Strauch;  Lance Stewart;  Michael S. Diamond;  David Veesler;  David Baker
收藏  |  浏览/下载:19/0  |  提交时间:2020/10/26
Structure of the RNA-dependent RNA polymerase from COVID-19 virus 期刊论文
Science, 2020
作者:  Yan Gao;  Liming Yan;  Yucen Huang;  Fengjiang Liu;  Yao Zhao;  Lin Cao;  Tao Wang;  Qianqian Sun;  Zhenhua Ming;  Lianqi Zhang;  Ji Ge;  Litao Zheng;  Ying Zhang;  Haofeng Wang;  Yan Zhu;  Chen Zhu;  Tianyu Hu;  Tian Hua;  Bing Zhang;  Xiuna Yang;  Jun Li;  Haitao Yang;  Zhijie Liu;  Wenqing Xu;  Luke W. Guddat;  Quan Wang;  Zhiyong Lou;  Zihe Rao
收藏  |  浏览/下载:16/0  |  提交时间:2020/05/20
Live-animal imaging of native haematopoietic stem and progenitor cells 期刊论文
NATURE, 2020, 578 (7794) : 278-+
作者:  Gerstung, Moritz;  Jolly, Clemency;  Leshchiner, Ignaty;  Dentro, Stefan C.;  Gonzalez, Santiago;  Rosebrock, Daniel;  Mitchell, Thomas J.;  Rubanova, Yulia;  Anur, Pavana;  Yu, Kaixian;  Tarabichi, Maxime;  Deshwar, Amit;  Wintersinger, Jeff;  Kleinheinz, Kortine;  Vazquez-Garcia, Ignacio;  Haase, Kerstin;  Jerman, Lara;  Sengupta, Subhajit;  Macintyre, Geoff;  Malikic, Salem;  Donmez, Nilgun;  Livitz, Dimitri G.;  Cmero, Marek;  Demeulemeester, Jonas;  Schumacher, Steven;  Fan, Yu;  Yao, Xiaotong;  Lee, Juhee;  Schlesner, Matthias;  Boutros, Paul C.;  Bowtell, David D.;  Zhu, Hongtu;  Getz, Gad;  Imielinski, Marcin;  Beroukhim, Rameen;  Sahinalp, S. Cenk;  Ji, Yuan;  Peifer, Martin;  Markowetz, Florian;  Mustonen, Ville;  Yuan, Ke;  Wang, Wenyi;  Morris, Quaid D.;  Spellman, Paul T.;  Wedge, David C.;  Van Loo, Peter;  Deshwar, Amit G.;  Adams, David J.;  Campbell, Peter J.;  Cao, Shaolong;  Christie, Elizabeth L.;  Cun, Yupeng;  Dawson, Kevin J.;  Drews, Ruben M.;  Eils, Roland;  Fittall, Matthew;  Garsed, Dale W.;  Ha, Gavin;  Lee-Six, Henry;  Martincorena, Inigo;  Oesper, Layla;  Peto, Myron;  Raphael, Benjamin J.;  Salcedo, Adriana;  Shi, Ruian;  Shin, Seung Jun;  Spiro, Oliver;  Stein, Lincoln D.;  Vembu, Shankar;  Wheeler, David A.;  Yang, Tsun-Po
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under transplantation conditions(1,2). It has been particularly challenging to study dynamic HSC behaviour, given that the visualization of HSCs in the native niche in live animals has not, to our knowledge, been achieved. Here we describe a dual genetic strategy in mice that restricts reporter labelling to a subset of the most quiescent long-term HSCs (LT-HSCs) and that is compatible with current intravital imaging approaches in the calvarial bone marrow(3-5). We show that this subset of LT-HSCs resides close to both sinusoidal blood vessels and the endosteal surface. By contrast, multipotent progenitor cells (MPPs) show greater variation in distance from the endosteum and are more likely to be associated with transition zone vessels. LT-HSCs are not found in bone marrow niches with the deepest hypoxia and instead are found in hypoxic environments similar to those of MPPs. In vivo time-lapse imaging revealed that LT-HSCs at steady-state show limited motility. Activated LT-HSCs show heterogeneous responses, with some cells becoming highly motile and a fraction of HSCs expanding clonally within spatially restricted domains. These domains have defined characteristics, as HSC expansion is found almost exclusively in a subset of bone marrow cavities with bone-remodelling activity. By contrast, cavities with low bone-resorbing activity do not harbour expanding HSCs. These findings point to previously unknown heterogeneity within the bone marrow microenvironment, imposed by the stages of bone turnover. Our approach enables the direct visualization of HSC behaviours and dissection of heterogeneity in HSC niches.


A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.


  
Evidence for Majorana bound states in an iron-based superconductor 期刊论文
SCIENCE, 2018, 362 (6412) : 333-335
作者:  Wang, Dongfei;  Kong, Lingyuan;  Fan, Peng;  Chen, Hui;  Zhu, Shiyu;  Liu, Wenyao;  Cao, Lu;  Sun, Yujie;  Du, Shixuan;  Schneeloch, John;  Zhong, Ruidan;  Gu, Genda;  Fu, Liang;  Ding, Hong;  Gao, Hong-Jun
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Giant polarization in super-tetragonal thin films through interphase strain 期刊论文
SCIENCE, 2018, 361 (6401) : 494-497
作者:  Zhang, Linxing;  Chen, Jun;  Fan, Longlong;  Dieguez, Oswaldo;  Cao, Jiangli;  Pan, Zhao;  Wang, Yilin;  Wang, Jinguo;  Kim, Moon;  Deng, Shiqing;  Wang, Jiaou;  Wang, Huanhua;  Deng, Jinxia;  Yu, Ranbo;  Scott, James F.;  Xing, Xianran
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II 期刊论文
SCIENCE, 2018, 360 (6393) : 1109-1112
作者:  Pan, Xiaowei;  Ma, Jun;  Su, Xiaodong;  Cao, Peng;  Chang, Wenrui;  Liu, Zhenfeng;  Zhang, Xinzheng;  Li, Mei
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex 期刊论文
SCIENCE, 2017, 357 (6353) : 816-+
作者:  Su, Xiaodong;  Ma, Jun;  Wei, Xuepeng;  Cao, Peng;  Zhu, Dongjie;  Chang, Wenrui;  Liu, Zhenfeng;  Zhang, Xinzheng;  Li, Mei
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Satellite-based entanglement distribution over 1200 kilometers 期刊论文
SCIENCE, 2017, 356 (6343) : 1180-1184
作者:  Yin, Juan;  Cao, Yuan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Bo;  Dai, Hui;  Li, Guang-Bing;  Lu, Qi-Ming;  Gong, Yun-Hong;  Xu, Yu;  Li, Shuang-Lin;  Li, Feng-Zhi;  Yin, Ya-Yun;  Jiang, Zi-Qing;  Li, Ming;  Jia, Jian-Jun;  Ren, Ge;  He, Dong;  Zhou, Yi-Lin;  Zhang, Xiao-Xiang;  Wang, Na;  Chang, Xiang;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Shu, Rong;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27