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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders 期刊论文
Science, 2021
作者:  Simone Brioschi;  Wei-Le Wang;  Vincent Peng;  Meng Wang;  Irina Shchukina;  Zev J. Greenberg;  Jennifer K. Bando;  Natalia Jaeger;  Rafael S. Czepielewski;  Amanda Swain;  Denis A. Mogilenko;  Wandy L. Beatty;  Peter Bayguinov;  James A. J. Fitzpatrick;  Laura G. Schuettpelz;  Catrina C. Fronick;  Igor Smirnov;  Jonathan Kipnis;  Virginia S. Shapiro;  Gregory F. Wu;  Susan Gilfillan;  Marina Cella;  Maxim N. Artyomov;  Steven H. Kleinstein;  Marco Colonna
收藏  |  浏览/下载:22/0  |  提交时间:2021/07/27
3D genomics across the tree of life reveals condensin II as a determinant of architecture type 期刊论文
Science, 2021
作者:  Claire Hoencamp;  Olga Dudchenko;  Ahmed M. O. Elbatsh;  Sumitabha Brahmachari;  Jonne A. Raaijmakers;  Tom van Schaik;  Ángela Sedeño Cacciatore;  Vinícius G. Contessoto;  Roy G. H. P. van Heesbeen;  Bram van den Broek;  Aditya N. Mhaskar;  Hans Teunissen;  Brian Glenn St Hilaire;  David Weisz;  Arina D. Omer;  Melanie Pham;  Zane Colaric;  Zhenzhen Yang;  Suhas S. P. Rao;  Namita Mitra;  Christopher Lui;  Weijie Yao;  Ruqayya Khan;  Leonid L. Moroz;  Andrea Kohn;  Judy St. Leger;  Alexandria Mena;  Karen Holcroft;  Maria Cristina Gambetta;  Fabian Lim;  Emma Farley;  Nils Stein;  Alexander Haddad;  Daniel Chauss;  Ayse Sena Mutlu;  Meng C. Wang;  Neil D. Young;  Evin Hildebrandt;  Hans H. Cheng;  Christopher J. Knight;  Theresa L. U. Burnham;  Kevin A. Hovel;  Andrew J. Beel;  Pierre-Jean Mattei;  Roger D. Kornberg;  Wesley C. Warren;  Gregory Cary;  José Luis Gómez-Skarmeta;  Veronica Hinman;  Kerstin Lindblad-Toh;  Federica Di Palma;  Kazuhiro Maeshima;  Asha S. Multani;  Sen Pathak;  Liesl Nel-Themaat;  Richard R. Behringer;  Parwinder Kaur;  René H. Medema;  Bas van Steensel;  Elzo de Wit;  José N. Onuchic;  Michele Di Pierro;  Erez Lieberman Aiden;  Benjamin D. Rowland
收藏  |  浏览/下载:13/0  |  提交时间:2021/06/07
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape 期刊论文
Science, 2021
作者:  Paul-Albert Koenig;  Hrishikesh Das;  Hejun Liu;  Beate M. Kümmerer;  Florian N. Gohr;  Lea-Marie Jenster;  Lisa D. J. Schiffelers;  Yonas M. Tesfamariam;  Miki Uchima;  Jennifer D. Wuerth;  Karl Gatterdam;  Natalia Ruetalo;  Maria H. Christensen;  Caroline I. Fandrey;  Sabine Normann;  Jan M. P. Tödtmann;  Steffen Pritzl;  Leo Hanke;  Jannik Boos;  Meng Yuan;  Xueyong Zhu;  Jonathan L. Schmid-Burgk;  Hiroki Kato;  Michael Schindler;  Ian A. Wilson;  Matthias Geyer;  Kerstin U. Ludwig;  B. Martin Hällberg;  Nicholas C. Wu;  Florian I. Schmidt
收藏  |  浏览/下载:20/0  |  提交时间:2021/02/17
Gas chromatography–mass spectrometry analyses of encapsulated stable perovskite solar cells 期刊论文
Science, 2020
作者:  Lei Shi;  Martin P. Bucknall;  Trevor L. Young;  Meng Zhang;  Long Hu;  Jueming Bing;  Da Seul Lee;  Jincheol Kim;  Tom Wu;  Noboru Takamure;  David R. McKenzie;  Shujuan Huang;  Martin A. Green;  Anita W. Y. Ho-Baillie
收藏  |  浏览/下载:7/0  |  提交时间:2020/06/22
A multi‐array back‐projection approach for tsunami warning 期刊论文
Geophysical Research Letters, 2020
作者:  Y. Xie;  L. Meng
收藏  |  浏览/下载:10/0  |  提交时间:2020/05/25
Ligand-induced monoubiquitination of BIK1 regulates plant immunity 期刊论文
NATURE, 2020, 581 (7807) : 199-+
作者:  Shao, Wei;  Yang, Jiajun;  He, Ming;  Yu, Xiang-Yu;  Lee, Choong Heon;  Yang, Zhaohui;  Joyner, Alexandra L.;  Anderson, Kathryn V.;  Zhang, Jiangyang;  Tsou, Meng-Fu Bryan;  Shi, Hang;  Shi, Song-Hai
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/03

Recognition of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) triggers the first line of inducible defence against invading pathogens(1-3). Receptor-like cytoplasmic kinases (RLCKs) are convergent regulators that associate with multiple PRRs in plants(4). The mechanisms that underlie the activation of RLCKs are unclear. Here we show that when MAMPs are detected, the RLCK BOTRYTIS-INDUCED KINASE 1 (BIK1) is monoubiquitinated following phosphorylation, then released from the flagellin receptor FLAGELLIN SENSING 2 (FLS2)-BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments. The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activation of immune signalling. Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics that are distinct from those of the PRR FLS2. Our study reveals the intertwined regulation of PRR-RLCK complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling.


  
Microbiota-targeted maternal antibodies protect neonates from enteric infection 期刊论文
NATURE, 2020, 577 (7791) : 543-+
作者:  Zheng, Wen;  Zhao, Wenjing;  Wu, Meng;  Song, Xinyang;  Caro, Florence;  Sun, Ximei;  Gazzaniga, Francesca;  Stefanetti, Giuseppe;  Oh, Sungwhan;  Mekalanos, John J.;  Kasper, Dennis L.
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Although maternal antibodies protect newborn babies from infection(1,2), little is known about how protective antibodies are induced without prior pathogen exposure. Here we show that neonatal mice that lack the capacity to produce IgG are protected from infection with the enteric pathogen enterotoxigenic Escherichia coli by maternal natural IgG antibodies against the maternal microbiota when antibodies are delivered either across the placenta or through breast milk. By challenging pups that were fostered by either maternal antibody-sufficient or antibody-deficient dams, we found that IgG derived from breast milk was crucial for protection against mucosal disease induced by enterotoxigenic E. coli. IgG also provides protection against systemic infection by E. coli. Pups used the neonatal Fc receptor to transfer IgG from milk into serum. The maternal commensal microbiota can induce antibodies that recognize antigens expressed by enterotoxigenic E. coli and other Enterobacteriaceae species. Induction of maternal antibodies against a commensal Pantoea species confers protection against enterotoxigenic E. coli in pups. This role of the microbiota in eliciting protective antibodies to a specific neonatal pathogen represents an important host defence mechanism against infection in neonates.


Neonatal mice are protected against infection with the enteric pathogen enterotoxigenic Escherichia coli by maternally derived natural antibodies as well as by maternal commensal microbiota that induce antibodies that recognize antigens expressed by Enterobacteriaceae.


  
Dualities and non-Abelian mechanics 期刊论文
NATURE, 2020, 577 (7792) : 636-+
作者:  Song, Xinyang;  Sun, Ximei;  Oh, Sungwhan F.;  Wu, Meng;  Zhang, Yanbo;  Zheng, Wen;  Geva-Zatorsky, Naama;  Jupp, Ray;  Mathis, Diane;  Benoist, Christophe;  Kasper, Dennis L.
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

Dualities-mathematical mappings between different systems-can act as hidden symmetries that enable materials design beyond that suggested by crystallographic space groups.


Dualities are mathematical mappings that reveal links between apparently unrelated systems in virtually every branch of physics(1-8). Systems mapped onto themselves by a duality transformation are called self-dual and exhibit remarkable properties, as exemplified by the scale invariance of an Ising magnet at the critical point. Here we show how dualities can enhance the symmetries of a dynamical matrix (or Hamiltonian), enabling the design of metamaterials with emergent properties that escape a standard group theory analysis. As an illustration, we consider twisted kagome lattices(9-15), reconfigurable mechanical structures that change shape by means of a collapse mechanism(9). We observe that pairs of distinct configurations along the mechanism exhibit the same vibrational spectrum and related elastic moduli. We show that these puzzling properties arise from a duality between pairs of configurations on either side of a mechanical critical point. The critical point corresponds to a self-dual structure with isotropic elasticity even in the absence of spatial symmetries and a twofold-degenerate spectrum over the entire Brillouin zone. The spectral degeneracy originates from a version of Kramers'  theorem(16,17) in which fermionic time-reversal invariance is replaced by a hidden symmetry emerging at the self-dual point. The normal modes of the self-dual systems exhibit non-Abelian geometric phases(18,19) that affect the semiclassical propagation of wavepackets(20), leading to non-commuting mechanical responses. Our results hold promise for holonomic computation(21) and mechanical spintronics by allowing on-the-fly manipulation of synthetic spins carried by phonons.


  
Demonstration of cooling by the Muon Ionization Cooling Experiment 期刊论文
NATURE, 2020, 578 (7793) : 53-+
作者:  Zheng, Wen;  Zhao, Wenjing;  Wu, Meng;  Song, Xinyang;  Caro, Florence;  Sun, Ximei;  Gazzaniga, Francesca;  Stefanetti, Giuseppe;  Oh, Sungwhan;  Mekalanos, John J.;  Kasper, Dennis L.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

The use of accelerated beams of electrons, protons or ions has furthered the development of nearly every scientific discipline. However, high-energy muon beams of equivalent quality have not yet been delivered. Muon beams can be created through the decay of pions produced by the interaction of a proton beam with a target. Such '  tertiary'  beams have much lower brightness than those created by accelerating electrons, protons or ions. High-brightness muon beams comparable to those produced by state-of-the-art electron, proton and ion accelerators could facilitate the study of lepton-antilepton collisions at extremely high energies and provide well characterized neutrino beams(1-6). Such muon beams could be realized using ionization cooling, which has been proposed to increase muon-beam brightness(7,8). Here we report the realization of ionization cooling, which was confirmed by the observation of an increased number of low-amplitude muons after passage of the muon beam through an absorber, as well as an increase in the corresponding phase-space density. The simulated performance of the ionization cooling system is consistent with the measured data, validating designs of the ionization cooling channel in which the cooling process is repeated to produce a substantial cooling effect(9-11). The results presented here are an important step towards achieving the muon-beam quality required to search for phenomena at energy scales beyond the reach of the Large Hadron Collider at a facility of equivalent or reduced wfootprint(6).


  
Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion 期刊论文
SCIENCE, 2019, 366 (6468) : 1013-+
作者:  Leone, Robert D.;  Zhao, Liang;  Englert, Judson M.;  Sun, Im-Meng;  Oh, Min-Hee;  Sun, Im-Hong;  Arwood, Matthew L.;  Bettencourt, Ian A.;  Patel, Chirag H.;  Wen, Jiayu;  Tam, Ada;  Blosser, Richard L.;  Prchalova, Eva;  Alt, Jesse;  Rais, Rana;  Slusher, Barbara S.;  Powell, Jonathan D.
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/17