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Global maps of soil temperature 期刊论文
Global Change Biology, 2022
作者:  Jonas J. Lembrechts;  Johan van den Hoogen;  Juha Aalto;  Michael B. Ashcroft;  Pieter De Frenne;  Julia Kemppinen;  Martin Kopecký;  Miska Luoto;  Ilya M. D. Maclean;  Thomas W. Crowther;  Joseph J. Bailey;  Stef Haesen;  David H. Klinges;  Pekka Niittynen;  Brett R. Scheffers;  Koenraad Van Meerbeek;  Peter Aartsma;  Otar Abdalaze;  Mehdi Abedi;  Rien Aerts;  Negar Ahmadian;  Antje Ahrends;  Juha M. Alatalo;  Jake M. Alexander;  Camille Nina Allonsius;  Jan Altman;  Christof Ammann;  Christian Andres;  Christopher Andrews;  Jonas Ardö;  Nicola Arriga;  Alberto Arzac;  Valeria Aschero;  Rafael L. Assis;  Jakob Johann Assmann;  Maaike Y. Bader;  Khadijeh Bahalkeh;  Peter Baranč;  ok;  Isabel C. Barrio;  Agustina Barros;  Matti Barthel;  Edmund W. Basham;  Marijn Bauters;  Manuele Bazzichetto;  Luca Belelli Marchesini;  Michael C. Bell;  Juan C. Benavides;  José;  Luis Benito Alonso;  Bernd J. Berauer;  Jarle W. Bjerke;  Robert G. Bjö;  rk;  Mats P. Bjö;  rkman;  Katrin Bjö;  rnsdó;  ttir;  Benjamin Blonder;  Pascal Boeckx;  Julia Boike;  Stef Bokhorst;  ;  rbara N. S. Brum;  Josef Brů;  na;  Nina Buchmann;  Pauline Buysse;  José;  Luí;  s Camargo;  Otá;  vio C. Campoe;  Onur Candan;  Rafaella Canessa;  Nicoletta Cannone;  Michele Carbognani;  Jofre Carnicer;  Angé;  lica Casanova-Katny;  Simone Cesarz;  Bogdan Chojnicki;  Philippe Choler;  Steven L. Chown;  Edgar F. Cifuentes;  Marek Č;  iliak;  Tamara Contador;  Peter Convey;  Elisabeth J. Cooper;  Edoardo Cremonese;  Salvatore R. Curasi;  Robin Curtis;  Maurizio Cutini;  C. Johan Dahlberg;  Gergana N. Daskalova;  Miguel Angel de Pablo;  Stefano Della Chiesa;  ;  rgen Dengler;  Bart Deronde;  Patrice Descombes;  Valter Di Cecco;  Michele Di Musciano;  Jan Dick;  Romina D. Dimarco;  Jiri Dolezal;  Ellen Dorrepaal;  Jiř;  í;  Duš;  ek;  Nico Eisenhauer;  Lars Eklundh;  Todd E. Erickson;  Brigitta Erschbamer;  Werner Eugster;  Robert M. Ewers;  Dan A. Exton;  Nicolas Fanin;  Fatih Fazlioglu;  Iris Feigenwinter;  Giuseppe Fenu;  Olga Ferlian;  M. Rosa Ferná;  ndez Calzado;  Eduardo Ferná;  ndez-Pascual;  Manfred Finckh;  Rebecca Finger Higgens;  T'ai G. W. Forte;  Erika C. Freeman;  Esther R. Frei;  Eduardo Fuentes-Lillo;  Rafael A. Garcí;  a;  Marí;  a B. Garcí;  a;  Charly Gé;  ron;  Mana Gharun;  Dany Ghosn;  Khatuna Gigauri;  Anne Gobin;  Ignacio Goded;  Mathias Goeckede;  Felix Gottschall;  Keith Goulding;  Sanne Govaert;  Bente Jessen Graae;  Sarah Greenwood;  Caroline Greiser;  Achim Grelle;  Benoit Gué;  nard;  Mauro Guglielmin;  Joannè;  s Guillemot;  Peter Haase;  Sylvia Haider;  Aud H. Halbritter;  Maroof Hamid;  Albin Hammerle;  Arndt Hampe;  Siri V. Haugum;  Lucia Hederová;  Bernard Heinesch;  Carole Helfter;  Daniel Hepenstrick;  Maximiliane Herberich;  Mathias Herbst;  Luise Hermanutz;  David S. Hik;  Raú;  l Hoffré;  n;  ;  rgen Homeier;  Lukas Hö;  rtnagl;  Toke T. Hø;  ye;  Filip Hrbacek;  Kristoffer Hylander;  Hiroki Iwata;  Marcin Antoni Jackowicz-Korczynski;  Hervé;  Jactel;  ;  rvi Jä;  rveoja;  Szymon Jastrzę;  bowski;  Anke Jentsch;  Juan J. Jimé;  nez;  Ingibjö;  rg S. Jó;  nsdó;  ttir;  Tommaso Jucker;  Alistair S. Jump;  Radoslaw Juszczak;  ;  bert Kanka;  ;  t Kaš;  par;  George Kazakis;  Julia Kelly;  Anzar A. Khuroo;  Leif Klemedtsson;  Marcin Klisz;  Natascha Kljun;  Alexander Knohl;  Johannes Kobler;  Jozef Kollá;  r;  Martyna M. Kotowska;  Bence Ková;  cs;  Juergen Kreyling;  Andrea Lamprecht;  Simone I. Lang;  Christian Larson;  Keith Larson;  Kamil Laska;  Guerric le Maire;  Rachel I. Leihy;  Luc Lens;  Bengt Liljebladh;  Annalea Lohila;  Juan Lorite;  Benjamin Loubet;  Joshua Lynn;  Martin Macek;  Roy Mackenzie;  Enzo Magliulo;  Regine Maier;  Francesco Malfasi;  Františ;  ek Má;  liš;  Matě;  j Man;  Giovanni Manca;  Antonio Manco;  Tanguy Manise;  Paraskevi Manolaki;  Felipe Marciniak;  Radim Matula;  Ana Clara Mazzolari;  Sergiy Medinets;  Volodymyr Medinets;  Camille Meeussen;  Sonia Merinero;  Rita de Cá;  ssia Guimarã;  es Mesquita;  Katrin Meusburger;  Filip J. R. Meysman;  Sean T. Michaletz;  Ann Milbau;  Dmitry Moiseev;  Pavel Moiseev;  Andrea Mondoni;  Ruth Monfries;  Leonardo Montagnani;  Mikel Moriana-Armendariz;  Umberto Morra di Cella;  Martin Mö;  rsdorf;  Jonathan R. Mosedale;  Lena Muffler;  Miriam Muñ;  oz-Rojas;  Jonathan A. Myers;  Isla H. Myers-Smith;  Laszlo Nagy;  Marianna Nardino;  Ilona Naujokaitis-Lewis;  Emily Newling;  Lena Nicklas;  Georg Niedrist;  Armin Niessner;  Mats B. Nilsson;  Signe Normand;  Marcelo D. Nosetto;  Yann Nouvellon;  Martin A. Nuñ;  ez;  Romà;  Ogaya;  ;  ;  me Ogé;  e;  Joseph Okello;  Janusz Olejnik;  ;  rgen Eivind Olesen;  Ø;  ystein H. Opedal;  Simone Orsenigo;  Andrej Palaj;  Timo Pampuch;  Alexey V. Panov;  Meelis Pä;  rtel;  Ada Pastor;  Aní;  bal Pauchard;  Harald Pauli;  Marian Pavelka;  William D. Pearse;  Matthias Peichl;  Loï;  c Pellissier;  Rachel M. Penczykowski;  Josep Penuelas;  Matteo Petit Bon;  Alessandro Petraglia;  Shyam S. Phartyal;  Gareth K. Phoenix;  Casimiro Pio;  Andrea Pitacco;  Camille Pitteloud;  Roman Plichta;  Francesco Porro;  Miguel Portillo-Estrada;  ;  ;  me Poulenard;  Rafael Poyatos;  Anatoly S. Prokushkin;  Radoslaw Puchalka;  Mihai Puș;  caș;  Dajana Radujković;  Krystal Randall;  Amanda Ratier Backes;  Sabine Remmele;  Wolfram Remmers;  David Renault;  Anita C. Risch;  Christian Rixen;  Sharon A. Robinson;  Bjorn J. M. Robroek;  Adrian V. Rocha;  Christian Rossi;  Graziano Rossi;  Olivier Roupsard;  Alexey V. Rubtsov;  Patrick Saccone;  Clotilde Sagot;  Jhonatan Sallo Bravo;  Cinthya C. Santos;  Judith M. Sarneel;  Tobias Scharnweber;  Jonas Schmeddes;  Marius Schmidt;  Thomas Scholten;  Max Schuchardt;  Naomi Schwartz;  Tony Scott;  Julia Seeber;  Ana Cristina Segalin de Andrade;  Tim Seipel;  Philipp Semenchuk;  Rebecca A. Senior;  Josep M. Serra-Diaz;  Piotr Sewerniak;  Ankit Shekhar;  Nikita V. Sidenko;  Lukas Siebicke;  Laura Siegwart Collier;  Elizabeth Simpson;  David P. Siqueira;  Zuzana Sitková;  Johan Six;  Marko Smiljanic;  Stuart W. Smith;  Sarah Smith-Tripp;  Ben Somers;  Mia Vedel Sø;  rensen;  José;  Joã;  o L. L. Souza;  Bartolomeu Israel Souza;  Arildo Souza Dias;  Marko J. Spasojevic;  James D. M. Speed;  Fabien Spicher;  Angela Stanisci;  Klaus Steinbauer;  Rainer Steinbrecher;  Michael Steinwandter;  Michael Stemkovski;  ;  rg G. Stephan;  Christian Stiegler;  Stefan Stoll;  Martin Svá;  tek;  Miroslav Svoboda;  Torbern Tagesson;  Andrew J. Tanentzap;  Franziska Tanneberger;  Jean-Paul Theurillat;  Haydn J. D. Thomas;  Andrew D. Thomas;  Katja Tielbö;  rger;  Marcello Tomaselli;  Urs Albert Treier;  Mario Trouillier;  Pavel Dan Turtureanu;  Rosamond Tutton;  Vilna A. Tyystjä;  rvi;  Masahito Ueyama;  Karol Ujhá;  zy;  Mariana Ujhá;  zyová;  Domas Uogintas;  Anastasiya V. Urban;  Josef Urban;  Marek Urbaniak;  Tudor-Mihai Ursu;  Francesco Primo Vaccari;  Stijn Van de Vondel;  Liesbeth van den Brink;  Maarten Van Geel;  Vigdis Vandvik;  Pieter Vangansbeke;  Andrej Varlagin;  G. F. Veen;  Elmar Veenendaal;  Susanna E. Venn;  Hans Verbeeck;  Erik Verbrugggen;  Frank G. A. Verheijen;  Luis Villar;  Luca Vitale;  Pascal Vittoz;  Maria Vives-Ingla;  Jonathan von Oppen;  Josefine Walz;  Runxi Wang;  Yifeng Wang;  Robert G. Way;  Ronja E. M. Wedegä;  rtner;  Robert Weigel;  Jan Wild;  Matthew Wilkinson;  Martin Wilmking;  Lisa Wingate;  Manuela Winkler;  Sonja Wipf;  Georg Wohlfahrt;  Georgios Xenakis;  Yan Yang;  Zicheng Yu;  Kailiang Yu;  Florian Zellweger;  Jian Zhang;  Zhaochen Zhang;  Peng Zhao;  Klaudia Ziembliń;  ska;  Reiner Zimmermann;  Shengwei Zong;  Viacheslav I. Zyryanov;  Ivan Nijs;  Jonathan Lenoir
收藏  |  浏览/下载:41/0  |  提交时间:2022/02/23
De novo assembly, annotation, and comparative analysis of 26 diverse maize genomes 期刊论文
Science, 2021
作者:  Matthew B. Hufford;  Arun S. Seetharam;  Margaret R. Woodhouse;  Kapeel M. Chougule;  Shujun Ou;  Jianing Liu;  William A. Ricci;  Tingting Guo;  Andrew Olson;  Yinjie Qiu;  Rafael Della Coletta;  Silas Tittes;  Asher I. Hudson;  Alexandre P. Marand;  Sharon Wei;  Zhenyuan Lu;  Bo Wang;  Marcela K. Tello-Ruiz;  Rebecca D. Piri;  Na Wang;  Dong won Kim;  Yibing Zeng;  Christine H. O’Connor;  Xianran Li;  Amanda M. Gilbert;  Erin Baggs;  Ksenia V. Krasileva;  John L. Portwood;  Ethalinda K. S. Cannon;  Carson M. Andorf;  Nancy Manchanda;  Samantha J. Snodgrass;  David E. Hufnagel;  Qiuhan Jiang;  Sarah Pedersen;  Michael L. Syring;  David A. Kudrna;  Victor Llaca;  Kevin Fengler;  Robert J. Schmitz;  Jeffrey Ross-Ibarra;  Jianming Yu;  Jonathan I. Gent;  Candice N. Hirsch;  Doreen Ware;  R. Kelly Dawe
收藏  |  浏览/下载:19/0  |  提交时间:2021/08/10
Peta–electron volt gamma-ray emission from the Crab Nebula 期刊论文
Science, 2021
作者:  The LHAASO Collaboration*†;  Zhen Cao;  F. Aharonian;  Q. An;  Axikegu;  L. X. Bai;  Y. X. Bai;  Y. W. Bao;  D. Bastieri;  X. J. Bi;  Y. J. Bi;  H. Cai;  J. T. Cai;  Zhe Cao;  J. Chang;  J. F. Chang;  B. M. Chen;  E. S. Chen;  J. Chen;  Liang Chen;  Liang Chen;  Long Chen;  M. J. Chen;  M. L. Chen;  Q. H. Chen;  S. H. Chen;  S. Z. Chen;  T. L. Chen;  X. L. Chen;  Y. Chen;  N. Cheng;  Y. D. Cheng;  S. W. Cui;  X. H. Cui;  Y. D. Cui;  B. D’Ettorre Piazzoli;  B. Z. Dai;  H. L. Dai;  Z. G. Dai;  Danzengluobu;  D. della Volpe;  X. J. Dong;  K. K. Duan;  J. H. Fan;  Y. Z. Fan;  Z. X. Fan;  J. Fang;  K. Fang;  C. F. Feng;  L. Feng;  S. H. Feng;  Y. L. Feng;  B. Gao;  C. D. Gao;  L. Q. Gao;  Q. Gao;  W. Gao;  M. M. Ge;  L. S. Geng;  G. H. Gong;  Q. B. Gou;  M. H. Gu;  F. L. Guo;  J. G. Guo;  X. L. Guo;  Y. Q. Guo;  Y. Y. Guo;  Y. A. Han;  H. H. He;  H. N. He;  J. C. He;  S. L. He;  X. B. He;  Y. He;  M. Heller;  Y. K. Hor;  C. Hou;  X. Hou;  H. B. Hu;  S. Hu;  S. C. Hu;  X. J. Hu;  D. H. Huang;  Q. L. Huang;  W. H. Huang;  X. T. Huang;  X. Y. Huang;  Z. C. Huang;  F. Ji;  X. L. Ji;  H. Y. Jia;  K. Jiang;  Z. J. Jiang;  C. Jin;  T. Ke;  D. Kuleshov;  K. Levochkin;  B. B. Li;  Cheng Li;  Cong Li;  F. Li;  H. B. Li;  H. C. Li;  H. Y. Li;  Jian Li;  Jie Li;  K. Li;  W. L. Li;  X. R. Li;  Xin Li;  Xin Li;  Y. Li;  Y. Z. Li;  Zhe Li;  Zhuo Li;  E. W. Liang;  Y. F. Liang;  S. J. Lin;  B. Liu;  C. Liu;  D. Liu;  H. Liu;  H. D. Liu;  J. Liu;  J. L. Liu;  J. S. Liu;  J. Y. Liu;  M. Y. Liu;  R. Y. Liu;  S. M. Liu;  W. Liu;  Y. Liu;  Y. N. Liu;  Z. X. Liu;  W. J. Long;  R. Lu;  H. K. Lv;  B. Q. Ma;  L. L. Ma;  X. H. Ma;  J. R. Mao;  A. Masood;  Z. Min;  W. Mitthumsiri;  T. Montaruli;  Y. C. Nan;  B. Y. Pang;  P. Pattarakijwanich;  Z. Y. Pei;  M. Y. Qi;  Y. Q. Qi;  B. Q. Qiao;  J. J. Qin;  D. Ruffolo;  V. Rulev;  A. Saiz;  L. Shao;  O. Shchegolev;  X. D. Sheng;  J. Y. Shi;  H. C. Song;  Yu. V. Stenkin;  V. Stepanov;  Y. Su;  Q. N. Sun;  X. N. Sun;  Z. B. Sun;  P. H. T. Tam;  Z. B. Tang;  W. W. Tian;  B. D. Wang;  C. Wang;  H. Wang;  H. G. Wang;  J. C. Wang;  J. S. Wang;  L. P. Wang;  L. Y. Wang;  R. N. Wang;  Wei Wang;  Wei Wang;  X. G. Wang;  X. J. Wang;  X. Y. Wang;  Y. Wang;  Y. D. Wang;  Y. J. Wang;  Y. P. Wang;  Z. H. Wang;  Z. X. Wang;  Zhen Wang;  Zheng Wang;  D. M. Wei;  J. J. Wei;  Y. J. Wei;  T. Wen;  C. Y. Wu;  H. R. Wu;  S. Wu;  W. X. Wu;  X. F. Wu;  S. Q. Xi;  J. Xia;  J. J. Xia;  G. M. Xiang;  D. X. Xiao;  G. Xiao;  H. B. Xiao;  G. G. Xin;  Y. L. Xin;  Y. Xing;  D. L. Xu;  R. X. Xu;  L. Xue;  D. H. Yan;  J. Z. Yan;  C. W. Yang;  F. F. Yang;  J. Y. Yang;  L. L. Yang;  M. J. Yang;  R. Z. Yang;  S. B. Yang;  Y. H. Yao;  Z. G. Yao;  Y. M. Ye;  L. Q. Yin;  N. Yin;  X. H. You;  Z. Y. You;  Y. H. Yu;  Q. Yuan;  H. D. Zeng;  T. X. Zeng;  W. Zeng;  Z. K. Zeng;  M. Zha;  X. X. Zhai;  B. B. Zhang;  H. M. Zhang;  H. Y. Zhang;  J. L. Zhang;  J. W. Zhang;  L. X. Zhang;  Li Zhang;  Lu Zhang;  P. F. Zhang;  P. P. Zhang;  R. Zhang;  S. R. Zhang;  S. S. Zhang;  X. Zhang;  X. P. Zhang;  Y. F. Zhang;  Y. L. Zhang;  Yi Zhang;  Yong Zhang;  B. Zhao;  J. Zhao;  L. Zhao;  L. Z. Zhao;  S. P. Zhao;  F. Zheng;  Y. Zheng;  B. Zhou;  H. Zhou;  J. N. Zhou;  P. Zhou;  R. Zhou;  X. X. Zhou;  C. G. Zhu;  F. R. Zhu;  H. Zhu;  K. J. Zhu;  X. Zuo
收藏  |  浏览/下载:14/0  |  提交时间:2021/07/27
Magnetic excitations in infinite-layer nickelates 期刊论文
Science, 2021
作者:  H. Lu;  M. Rossi;  A. Nag;  M. Osada;  D. F. Li;  K. Lee;  B. Y. Wang;  M. Garcia-Fernandez;  S. Agrestini;  Z. X. Shen;  E. M. Been;  B. Moritz;  T. P. Devereaux;  J. Zaanen;  H. Y. Hwang;  Ke-Jin Zhou;  W. S. Lee
收藏  |  浏览/下载:15/0  |  提交时间:2021/07/27
Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons 期刊论文
Science, 2021
作者:  Dylan A. Reid;  Patrick J. Reed;  Johannes C. M. Schlachetzki;  Ioana I. Nitulescu;  Grace Chou;  Enoch C. Tsui;  Jeffrey R. Jones;  Sahaana Chandran;  Ake T. Lu;  Claire A. McClain;  Jean H. Ooi;  Tzu-Wen Wang;  Addison J. Lana;  Sara B. Linker;  Anthony S. Ricciardulli;  Shong Lau;  Simon T. Schafer;  Steve Horvath;  Jesse R. Dixon;  Nasun Hah;  Christopher K. Glass;  Fred H. Gage
收藏  |  浏览/下载:15/0  |  提交时间:2021/04/06
Key rules of life and the fading cryosphere: Impacts in alpine lakes and streams 期刊论文
Global Change Biology, 2020
作者:  James J. Elser;  Chenxi Wu;  Angé;  lica L. Gonzá;  lez;  Daniel H. Shain;  Heidi J. Smith;  Ruben Sommaruga;  Craig E. Williamson;  Janice Brahney;  Scott Hotaling;  Joseph Vanderwall;  Jinlei Yu;  Vladimir Aizen;  Elena Aizen;  Tom J. Battin;  Roberto Camassa;  Xiu Feng;  Hongchen Jiang;  Lixin Lu;  John J. Qu;  Ze Ren;  Jun Wen;  Lijuan Wen;  H. Arthur Woods;  Xiong Xiong;  Jun Xu;  Gongliang Yu;  Joel T. Harper;  Jasmine E. Saros
收藏  |  浏览/下载:9/0  |  提交时间:2020/10/26
Forecasting extreme stratospheric polar vortex events 期刊论文
Nature Communications, 2020
作者:  L. J. Gray;  M. J. Brown;  J. Knight;  M. Andrews;  H. Lu;  C. O’;  Reilly;  J. Anstey
收藏  |  浏览/下载:9/0  |  提交时间:2020/09/22
An orally available non-nucleotide STING agonist with antitumor activity 期刊论文
Science, 2020
作者:  Bo-Sheng Pan;  Samanthi A. Perera;  Jennifer A. Piesvaux;  Jeremy P. Presland;  Gottfried K. Schroeder;  Jared N. Cumming;  B. Wesley Trotter;  Michael D. Altman;  Alexei V. Buevich;  Brandon Cash;  Saso Cemerski;  Wonsuk Chang;  Yiping Chen;  Peter J. Dandliker;  Guo Feng;  Andrew Haidle;  Timothy Henderson;  James Jewell;  Ilona Kariv;  Ian Knemeyer;  Johnny Kopinja;  Brian M. Lacey;  Jason Laskey;  Charles A. Lesburg;  Rui Liang;  Brian J. Long;  Min Lu;  Yanhong Ma;  Ellen C. Minnihan;  Greg O’Donnell;  Ryan Otte;  Laura Price;  Larissa Rakhilina;  Berengere Sauvagnat;  Sharad Sharma;  Sriram Tyagarajan;  Hyun Woo;  Daniel F. Wyss;  Serena Xu;  David Jonathan Bennett;  George H. Addona
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/25
Current European flood-rich period exceptional compared with past 500 years 期刊论文
NATURE, 2020, 583 (7817) : 560-+
作者:  ;  nter Blö;  schl;  Andrea Kiss;  Alberto Viglione;  Mariano Barriendos;  Oliver Bö;  hm;  Rudolf Brá;  zdil;  Denis Coeur;  Gaston Demaré;  e;  Maria Carmen Llasat;  Neil Macdonald;  Dag Retsö;  Lars Roald;  Petra Schmocker-Fackel;  Inê;  s Amorim;  Monika Bě;  ;  nová;  Gerardo Benito;  Chiara Bertolin;  Dario Camuffo;  Daniel Cornel;  Radosł;  aw Doktor;  ;  bor Elleder;  Silvia Enzi;  Joã;  o Carlos Garcia;  ;  diger Glaser;  Julia Hall;  Klaus Haslinger;  Michael Hofstä;  tter;  ;  rgen Komma;  Danuta Limanó;  wka;  David Lun;  Andrei Panin;  Juraj Parajka;  Hrvoje Petrić;  Fernando S. Rodrigo;  Christian Rohr;  Johannes Schö;  nbein;  Lothar Schulte;  Luí;  s Pedro Silva;  Willem H. J. Toonen;  Peter Valent;  ;  rgen Waser;  Oliver Wetter
收藏  |  浏览/下载:40/0  |  提交时间:2020/08/09

There are concerns that recent climate change is altering the frequency and magnitude of river floods in an unprecedented way(1). Historical studies have identified flood-rich periods in the past half millennium in various regions of Europe(2). However, because of the low temporal resolution of existing datasets and the relatively low number of series, it has remained unclear whether Europe is currently in a flood-rich period from a long-term perspective. Here we analyse how recent decades compare with the flood history of Europe, using a new database composed of more than 100 high-resolution (sub-annual) historical flood series based on documentary evidence covering all major regions of Europe. We show that the past three decades were among the most flood-rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality. We identified nine flood-rich periods and associated regions. Among the periods richest in floods are 1560-1580 (western and central Europe), 1760-1800 (most of Europe), 1840-1870 (western and southern Europe) and 1990-2016 (western and central Europe). In most parts of Europe, previous flood-rich periods occurred during cooler-than-usual phases, but the current flood-rich period has been much warmer. Flood seasonality is also more pronounced in the recent period. For example, during previous flood and interflood periods, 41 per cent and 42 per cent of central European floods occurred in summer, respectively, compared with 55 per cent of floods in the recent period. The exceptional nature of the present-day flood-rich period calls for process-based tools for flood-risk assessment that capture the physical mechanisms involved, and management strategies that can incorporate the recent changes in risk.


Analysis of thousands of historical documents recording floods in Europe shows that flooding characteristics in recent decades are unlike those of previous centuries.


  
Mechanical regulation of glycolysis via cytoskeleton architecture 期刊论文
NATURE, 2020, 578 (7796) : 621-+
作者:  Faivre, Emily J.;  McDaniel, Keith F.;  Albert, Daniel H.;  Mantena, Srinivasa R.;  Plotnik, Joshua P.;  Wilcox, Denise;  Zhang, Lu;  Bui, Mai H.;  Sheppard, George S.;  Wang, Le;  Sehgal, Vasudha;  Lin, Xiaoyu;  Huang, Xiaoli;  Lu, Xin;  Uziel, Tamar;  Hessler, Paul;  Lam, Lloyd T.;  Bellin, Richard J.;  Mehta, Gaurav;  Fidanze, Steve;  Pratt, John K.;  Liu, Dachun;  Hasvold, Lisa A.;  Sun, Chaohong;  Panchal, Sanjay C.;  Nicolette, John J.;  Fossey, Stacey L.;  Park, Chang H.;  Longenecker, Kenton;  Bigelow, Lance;  Torrent, Maricel;  Rosenberg, Saul H.;  Kati, Warren M.;  Shen, Yu
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility(1-3). Although all of these processes consume energy(4,5), it is unknown whether and how cells adapt their metabolic activity to variable mechanical cues. Here we report that the transfer of human bronchial epithelial cells from stiff to soft substrates causes a downregulation of glycolysis via proteasomal degradation of the rate-limiting metabolic enzyme phosphofructokinase (PFK). PFK degradation is triggered by the disassembly of stress fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TRIM21). Transformed non-small-cell lung cancer cells, which maintain high glycolytic rates regardless of changing environmental mechanics, retain PFK expression by downregulating TRIM21, and by sequestering residual TRIM21 on a stress-fibre subset that is insensitive to substrate stiffness. Our data reveal a mechanism by which glycolysis responds to architectural features of the actomyosin cytoskeleton, thus coupling cell metabolism to the mechanical properties of the surrounding tissue. These processes enable normal cells to tune energy production in variable microenvironments, whereas the resistance of the cytoskeleton in response to mechanical cues enables the persistence of high glycolytic rates in cancer cells despite constant alterations of the tumour tissue.


Glycolysis in normal epithelial cells responds to microenvironmental mechanics via the modulation of actin bundles that sequester the phosphofructokinase-targeting ubiquitin ligase TRIM21, a process superseded by persistent actin bundles in cancer cells.