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Measurement report: Effects of anthropogenic emissions and environmental factors on the formation of biogenic secondary organic aerosol (BSOA) in a coastal city of southeastern China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Youwei Hong, Xinbei Xu, Dan Liao, Taotao Liu, Xiaoting Ji, Ke Xu, Chunyang Liao, Ting Wang, Chunshui Lin, and Jinsheng Chen
收藏  |  浏览/下载：17/0  |  提交时间：2022/06/24
Assimilating Fengyun-4A observations to improve WRF-Chem PM2.5 predictions in China 期刊论文
Atmospheric Research, 2021
作者:  Jia Hong, Feiyue Mao, Wei Gong, Yuan Gan, ... Jiangping Chen
收藏  |  浏览/下载：10/0  |  提交时间：2021/10/22
Aqueous production of secondary organic aerosol from fossil-fuel emissions in winter Beijing haze 期刊论文
Proceedings of the National Academy of Science, 2021
作者:  Junfeng Wang;  Jianhuai Ye;  Qi Zhang;  Jian Zhao;  Yangzhou Wu;  Jingyi Li;  Dantong Liu;  Weijun Li;  Yange Zhang;  Cheng Wu;  Conghui Xie;  Yiming Qin;  Yali Lei;  Xiangpeng Huang;  Jianping Guo;  Pengfei Liu;  Pingqing Fu;  Yongjie Li;  Hyun Chul Lee;  Hyoungwoo Choi;  Jie Zhang;  Hong Liao;  Mindong Chen;  Yele Sun;  Xinlei Ge;  Scot T. Martin;  Daniel J. Jacob
收藏  |  浏览/下载：15/0  |  提交时间：2021/02/22
An operational statistical downscaling prediction model of the winter monthly temperature over China based on a multi-model ensemble 期刊论文
Atmospheric Research, 2020
作者:  Ying Liu, Ke Fan, Lijuan Chen, Hong-Li Ren, ... Changzheng Liu
收藏  |  浏览/下载：7/0  |  提交时间：2020/09/22
Temperature effects on optical properties and chemical composition of secondary organic aerosol derived from n-dodecane 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 8123-8137
作者:  Li, Junling;  Wang, Weigang;  Li, Kun;  Zhang, Wenyu;  Peng, Chao;  Zhou, Li;  Shi, Bo;  Chen, Yan;  Liu, Mingyuan;  Li, Hong;  Ge, Maofa
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/21
Volatile organic compounds and ozone air pollution in an oil production region in northern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (11) : 7069-7086
作者:  Chen, Tianshu;  Xue, Likun;  Zheng, Penggang;  Zhang, Yingnan;  Liu, Yuhong;  Sun, Jingjing;  Han, Guangxuan;  Li, Hongyong;  Zhang, Xin;  Li, Yunfeng;  Li, Hong;  Dong, Can;  Xu, Fei;  Zhang, Qingzhu;  Wang, Wenxing
收藏  |  浏览/下载：10/0  |  提交时间：2020/06/22
Spatial-temporal variations and process analysis of O-3 pollution in Hangzhou during the G20 summit 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 5963-5976
作者:  Ni, Zhi-Zhen;  Luo, Kun;  Gao, Yang;  Gao, Xiang;  Jiang, Fei;  Huang, Cheng;  Fan, Jian-Ren;  Fu, Joshua S.;  Chen, Chang-Hong
收藏  |  浏览/下载：7/0  |  提交时间：2020/05/20
Characteristics of methanesulfonic acid, non-sea-salt sulfate and organic carbon aerosols over the Amundsen Sea, Antarctica 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (9) : 5405-5424
作者:  Jung, Jinyoung;  Hong, Sang-Bum;  Chen, Meilian;  Hur, Jin;  Jiao, Liping;  Lee, Youngju;  Park, Keyhong;  Hahm, Doshik;  Choi, Jung-Ok;  Yang, Eun Jin;  Park, Jisoo;  Kim, Tae-Wan;  Lee, SangHoon
收藏  |  浏览/下载：11/0  |  提交时间：2020/05/13
Characteristics and source apportionment of PM2.5 on an island in Southeast China: Impact of sea-salt and monsoon 期刊论文
ATMOSPHERIC RESEARCH, 2020, 235
作者:  Liu, Taotao;  Hu, Baoye;  Yang, Yuxiang;  Li, Mengren;  Hong, Youwei;  Xu, Xinbei;  Xu, Lingling;  Chen, Naihua;  Chen, Yanting;  Xiao, Hang;  Chen, Jinsheng
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/02
PM2.5  Source apportionment  Island  East Asian monsoon  Sea salt  
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.