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Variability of aerosol-cloud interactions induced by different cloud droplet nucleation schemes 期刊论文
Atmospheric Research, 2020
作者:  D.Y. Chang, J. Lelieveld, B. Steil, J. Yoon, ... A.-H. Kim
收藏  |  浏览/下载:12/0  |  提交时间:2020/11/24
Constraining remote oxidation capacity with ATom observations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 7753-7781
作者:  Travis, Katherine R.;  Heald, Colette L.;  Allen, Hannah M.;  Apel, Eric C.;  Arnold, Stephen R.;  Blake, Donald R.;  Brune, William H.;  Chen, Xin;  Commane, Roisin;  Crounse, John D.;  Daube, Bruce C.;  Diskin, Glenn S.;  Elkins, James W.;  Evans, Mathew J.;  Hall, Samuel R.;  Hintsa, Eric J.;  Hornbrook, Rebecca S.;  Kasibhatla, Prasad S.;  Kim, Michelle J.;  Luo, Gan;  McKain, Kathryn;  Millet, Dylan B.;  Moore, Fred L.;  Peischl, Jeffrey;  Ryerson, Thomas B.;  Sherwen, Tomas;  Thames, Alexander B.;  Ullmann, Kirk;  Wang, Xuan;  Wennberg, Paul O.;  Wolfe, Glenn M.;  Yu, Fangqun
收藏  |  浏览/下载:49/0  |  提交时间:2020/08/18
America First versus Wolf Warriors: Pandemic Diplomacy in Southeast Asia 科技报告
来源:Center for Strategic & International Studies. 出版年: 2020
作者:  Gregory B. Poling;  Kim Mai Tran
收藏  |  浏览/下载:107/0  |  提交时间:2020/06/22
African Dust Particles over the Western Caribbean Part I: Impact on air quality over the Yucatan Peninsula 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Carolina Ramirez-Romero, Alejandro Jaramillo, Maria F. Cordoba, Graciela B. Raga, Javier Miranda, Harry Alvarez-Ospina, Daniel Rosas, Talib Amador, Jong Sung Kim, Jacqueline Yakobi-Hancock, Darrel Baumgardner, and Luis A. Ladino
收藏  |  浏览/下载:11/0  |  提交时间:2020/06/22
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Microbial signatures in tumours and blood 期刊论文
NATURE, 2020, 579 (7800) : 502-503
作者:  Goodman, Russell P.;  Markhard, Andrew L.;  Shah, Hardik;  Sharma, Rohit;  Skinner, Owen S.;  Clish, Clary B.;  Deik, Amy;  Patgiri, Anupam;  Hsu, Yu-Han H.;  Masia, Ricard;  Noh, Hye Lim;  Suk, Sujin;  Goldberger, Olga;  Hirschhorn, Joel N.;  Yellen, Gary;  Kim, Jason K.;  Mootha, Vamsi K.
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

Microbiome signatures as putative cancer diagnostics.


Analysis of nucleic-acid sequences from human cancers, along with samples from adjacent tissue and blood, reveals the presence of microorganisms in tumours and blood across cancers.


  
IL-17a promotes sociability in mouse models of neurodevelopmental disorders 期刊论文
NATURE, 2020, 577 (7789) : 249-+
作者:  Reed, Michael Douglas;  Yim, Yeong Shin;  Wimmer, Ralf D.;  Kim, Hyunju;  Ryu, Changhyeon;  Welch, Gwyneth Margaret;  Andina, Matias;  King, Hunter Oren;  Waisman, Ari;  Halassa, Michael M.;  Huh, Jun R.;  Choi, Gloria B.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

A subset of children with autism spectrum disorder appear to show an improvement in their behavioural symptoms during the course of a fever, a sign of systemic inflammation(1,2). Here we elucidate the molecular and neural mechanisms that underlie the beneficial effects of inflammation on social behaviour deficits in mice. We compared an environmental model of neurodevelopmental disorders in which mice were exposed to maternal immune activation (MIA) during embryogenesis(3,4) with mouse models that are genetically deficient for contactin-associated protein-like 2 (Cntnap2)(5), fragile X mental retardation-1 (Fmr1)(6) or Sh3 and multiple ankyrin repeat domains 3 (Shank3)(7). We establish that the social behaviour deficits in offspring exposed to MIA can be temporarily rescued by the inflammatory response elicited by the administration of lipopolysaccharide (LPS). This behavioural rescue was accompanied by a reduction in neuronal activity in the primary somatosensory cortex dysgranular zone (S1DZ), the hyperactivity of which was previously implicated in the manifestation of behavioural phenotypes associated with offspring exposed to MIA(8). By contrast, we did not observe an LPS-induced rescue of social deficits in the monogenic models. We demonstrate that the differences in responsiveness to the LPS treatment between the MIA and the monogenic models emerge from differences in the levels of cytokine production. LPS treatment in monogenic mutant mice did not induce amounts of interleukin-17a (IL-17a) comparable to those induced in MIA offspring  bypassing this difference by directly delivering IL-17a into S1DZ was sufficient to promote sociability in monogenic mutant mice as well as in MIA offspring. Conversely, abrogating the expression of IL-17 receptor subunit a (IL-17Ra) in the neurons of the S1DZ eliminated the ability of LPS to reverse the sociability phenotypes in MIA offspring. Our data support a neuroimmune mechanism that underlies neurodevelopmental disorders in which the production of IL-17a during inflammation can ameliorate the expression of social behaviour deficits by directly affecting neuronal activity in the central nervous system.


  
Missing OH reactivity in the global marine boundary layer 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 4013-4029
作者:  Thames, Alexander B.;  Brune, William H.;  Miller, David O.;  Allen, Hannah M.;  Apel, Eric C.;  Blake, Donald R.;  Bui, T. Paul;  Commane, Roisin;  Crounse, John D.;  Daube, Bruce C.;  Diskin, Glenn S.;  DiGangi, Joshua P.;  Elkins, JamesW.;  Hall, Samuel R.;  Hanisco, Thomas F.;  Hannun, Reem A.;  Hintsa, Eric;  Hornbrook, Rebecca S.;  Kim, Michelle J.;  McKain, Kathryn;  Moore, Fred L.;  Nicely, Julie M.;  Peischl, Jeffrey;  Ryerson, Thomas B.;  St Clair, Jason M.;  Sweeney, Colm;  Teng, Alex;  Thompson, Chelsea R.;  Ullmann, Kirk;  Wennberg, Paul O.;  Wolfe, Glenn M.
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
Ruthenium isotope vestige of Earth's pre-late-veneer mantle preserved in Archaean rocks 期刊论文
NATURE, 2020, 579 (7798) : 240-+
作者:  Abadie, Valerie;  Kim, Sangman M.;  Lejeune, Thomas;  Palanski, Brad A.;  Ernest, Jordan D.;  Tastet, Olivier;  Voisine, Jordan;  Discepolo, Valentina;  Marietta, Eric, V;  Hawash, Mohamed B. F.;  Ciszewski, Cezary;  Bouziat, Romain;  Panigrahi, Kaushik;  Horwath, Irina;  Zurenski, Matthew A.;  Lawrence, Ian;  Dumaine, Anne;  Yotova, Vania;  Grenier, Jean-Christophe;  Murray, Joseph A.;  Khosla, Chaitan;  Barreiro, Luis B.;  Jabri, Bana
收藏  |  浏览/下载:31/0  |  提交时间:2020/05/13

The accretion of volatile-rich material from the outer Solar System represents a crucial prerequisite for Earth to develop oceans and become a habitable planet(1-4). However, the timing of this accretion remains controversial(5-8). It has been proposed that volatile elements were added to Earth by the late accretion of a late veneer consisting of carbonaceous-chondrite-like material after core formation had ceased(6,9,10). This view could not be reconciled with the ruthenium (Ru) isotope composition of carbonaceous chondrites(5,11), which is distinct from that of the modern mantle(12), or of any known meteorite group(5). As a possible solution, Earth'  s pre-late-veneer mantle could already have contained a fraction of Ru that was not fully extracted by core formation(13). The presence of such pre-late-veneer Ru can only be established if its isotope composition is distinct from that of the modern mantle. Here we report the first high-precision, mass-independent Ru isotope compositions for Eoarchaean ultramafic rocks from southwest Greenland, which display a relative Ru-100 excess of 22 parts per million compared with the modern mantle value. This Ru-100 excess indicates that the source of the Eoarchaean rocks already contained a substantial fraction of Ru before the accretion of the late veneer. By 3.7 billion years ago, the mantle beneath southwest Greenland had not yet fully equilibrated with late accreted material. Otherwise, no Ru isotopic difference relative to the modern mantle would be observed. If constraints from other highly siderophile elements besides Ru are also considered(14), the composition of the modern mantle can only be reconciled if the late veneer contained substantial amounts of carbonaceous-chondrite-like materials with their characteristic Ru-100 deficits. These data therefore relax previous constraints on the late veneer and are consistent with volatile-rich material from the outer Solar System being delivered to Earth during late accretion.


  
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage (vol 551, pg 629, 2017) 期刊论文
NATURE, 2020, 580 (7802) : E5-E5
作者:  Lu, Zhihao;  Zou, Jianling;  Li, Shuang;  Topper, Michael J.;  Tao, Yong;  Zhang, Hao;  Jiao, Xi;  Xie, Wenbing;  Kong, Xiangqian;  Vaz, Michelle;  Li, Huili;  Cai, Yi;  Xia, Limin;  Huang, Peng;  Rodgers, Kristen;  Lee, Beverly;  Riemer, Joanne B.;  Day, Chi-Ping;  Yen, Ray-Whay Chiu;  Cui, Ying;  Wang, Yujiao;  Wang, Yanni;  Zhang, Weiqiang;  Easwaran, Hariharan;  Hulbert, Alicia;  Kim, KiBem;  Juergens, Rosalyn A.;  Yang, Stephen C.;  Battafarano, Richard J.;  Bush, Errol L.;  Broderick, Stephen R.;  Cattaneo, Stephen M.;  Brahmer, Julie R.;  Rudin, Charles M.;  Wrangle, John;  Mei, Yuping;  Kim, Young J.;  Zhang, Bin;  Wang, Ken Kang-Hsin;  Forde, Patrick M.;  Margolick, Joseph B.;  Nelkin, Barry D.;  Zahnow, Cynthia A.;  Pardoll, Drew M.;  Housseau, Franck;  Baylin, Stephen B.;  Shen, Lin;  Brock, Malcolm V.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/03