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Elevated dust layers inhibit dissipation of heavy anthropogenic surface air pollution 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Zhuang Wang, Cheng Liu, Zhouqing Xie, Qihou Hu, Meinrat O. Andreae, Yunsheng Dong, Chun Zhao, Ting Liu, Yizhi Zhu, Haoran Liu, Chengzhi Xing, Wei Tan, Xiangguang Ji, Jinan Lin, and Jianguo Liu
收藏  |  浏览/下载:8/0  |  提交时间:2020/06/01
China's emission control strategies have suppressed unfavorable influences of climate on wintertime PM2.5 concentrations in Beijing since 2002 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (3) : 1497-1505
作者:  Gao, Meng;  Liu, Zirui;  Zheng, Bo;  Ji, Dongsheng;  Sherman, Peter;  Song, Shaojie;  Xin, Jinyuan;  Liu, Cheng;  Wang, Yuesi;  Zhang, Qiang;  Xing, Jia;  Jiang, Jingkun;  Wang, Zifa;  Carmichael, Gregory R.;  McElroy, Michael B.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:143/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Palmitoylation of NOD1 and NOD2 is required for bacterial sensing 期刊论文
SCIENCE, 2019, 366 (6464) : 460-+
作者:  Lu, Yan;  Zheng, Yuping;  Coyaud, Etienne;  Zhang, Chao;  Selvabaskaran, Apiraam;  Yu, Yuyun;  Xu, Zizhen;  Weng, Xialian;  Chen, Ji Shun;  Meng, Ying;  Warner, Neil;  Cheng, Xiawei;  Liu, Yangyang;  Yao, Bingpeng;  Hu, Hu;  Xia, Zonping;  Muise, Aleixo M.;  Klip, Amira;  Brumell, John H.;  Girardin, Stephen E.;  Ying, Songmin;  Fairn, Gregory D.;  Raught, Brian;  Sun, Qiming;  Neculai, Dante
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Analyzing the variation of the precipitation of coastal areas of eastern China and its association with sea surface temperature (SST) of other seas 期刊论文
ATMOSPHERIC RESEARCH, 2019, 219: 114-122
作者:  Ji, Chenxu;  Zhang, Yuanzhi;  Cheng, Qiuming;  Li, Yu;  Jiang, Tingchen;  Liang, X. San
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/26
Precipitation  Sea Surface Temperature  Coastal areas of the Eastern China  Seasonal variation  Inter-annual variation  
An electron transfer path connects subunits of a mycobacterial respiratory supercomplex 期刊论文
SCIENCE, 2018, 362 (6418) : 1020-+
作者:  Gong, Hongri;  Li, Jun;  Xu, Ao;  Tang, Yanting;  Ji, Wenxin;  Gao, Ruogu;  Wang, Shuhui;  Yu, Lu;  Tian, Changlin;  Li, Jingwen;  Yen, Hsin-Yung;  Lam, Sin Man;  Shui, Guanghou;  Yang, Xiuna;  Sun, Yuna;  Li, Xuemei;  Jia, Minze;  Yang, Cheng;  Jiang, Biao;  Lou, Zhiyong;  Robinson, Carol V.;  Wong, Luet-Lok;  Guddat, Luke W.;  Sun, Fei;  Wang, Quan;  Rao, Zihe
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Vertically resolved characteristics of air pollution during two severe winter haze episodes in urban Beijing, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (4) : 2495-2509
作者:  Wang, Qingqing;  Sun, Yele;  Xu, Weiqi;  Du, Wei;  Zhou, Libo;  Tang, Guiqian;  Chen, Chen;  Cheng, Xueling;  Zhao, Xiujuan;  Ji, Dongsheng;  Han, Tingting;  Wang, Zhe;  Li, Jie;  Wang, Zifa
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly 期刊论文
SCIENCE, 2017, 358 (6365) : 933-+
作者:  Yuan, Ling;  Huang, Xing-Yao;  Liu, Zhong-Yu;  Zhang, Feng;  Zhu, Xing-Liang;  Yu, Jiu-Yang;  Ji, Xue;  Xu, Yan-Peng;  Li, Guanghui;  Li, Cui;  Wang, Hong-Jiang;  Deng, Yong-Qiang;  Wu, Menghua;  Cheng, Meng-Li;  Ye, Qing;  Xie, Dong-Yang;  Li, Xiao-Feng;  Wang, Xiangxi;  Shi, Weifeng;  Hu, Baoyang;  Shi, Pei-Yong;  Xu, Zhiheng;  Qin, Cheng-Feng
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Ground-to-satellite quantum teleportation 期刊论文
NATURE, 2017, 549 (7670) : 70-+
作者:  Ren, Ji-Gang;  Xu, Ping;  Yong, Hai-Lin;  Zhang, Liang;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Yang, Meng;  Li, Li;  Yang, Kui-Xing;  Han, Xuan;  Yao, Yong-Qiang;  Li, Ji;  Wu, Hai-Yan;  Wan, Song;  Liu, Lei;  Liu, Ding-Quan;  Kuang, Yao-Wu;  He, Zhi-Ping;  Shang, Peng;  Guo, Cheng;  Zheng, Ru-Hua;  Tian, Kai;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Lu, Chao-Yang;  Shu, Rong;  Chen, Yu-Ao;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27