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Fluorescence characteristics, absorption properties, and radiative effects of water-soluble organic carbon in seasonal snow across northeastern China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Xiaoying Niu, Wei Pu, Pingqing Fu, Yang Chen, Yuxuan Xing, Dongyou Wu, Ziqi Chen, Tenglong Shi, Yue Zhou, Hui Wen, and Xin Wang
收藏  |  浏览/下载:16/0  |  提交时间:2022/06/24
Assessments of the factors controlling latent heat flux and the coupling degree between an alpine wetland and the atmosphere on the Qinghai-Tibetan Plateau in summer 期刊论文
ATMOSPHERIC RESEARCH, 2020, 240
作者:  Chen, Jinlei;  Wen, Jun;  Kang, Shichang;  Meng, Xianhong;  Tian, Hui;  Ma, Xin;  Yuan, Yuan
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
Wetlands  Latent heat  Coupling  Control factor  CLM  
Marine organic matter in the remote environment of the Cape Verde islands - an introduction and overview to the MarParCloud campaign 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (11) : 6921-6951
作者:  van Pinxteren, Manuela;  Fomba, Khanneh Wadinga;  Triesch, Nadja;  Stolle, Christian;  Wurl, Oliver;  Bahlmann, Enno;  Gong, Xianda;  Voigtlaender, Jens;  Wex, Heike;  Robinson, Tiera-Brandy;  Barthel, Stefan;  Zeppenfeld, Sebastian;  Hoffmann, Erik Hans;  Roveretto, Marie;  Li, Chunlin;  Grosselin, Benoit;  Daele, Veronique;  Senf, Fabian;  van Pinxteren, Dominik;  Manzi, Malena;  Zabalegui, Nicolas;  Frka, Sanja;  Gasparovic, Blazenka;  Pereira, Ryan;  Li, Tao;  Wen, Liang;  Li, Jiarong;  Zhu, Chao;  Chen, Hui;  Chen, Jianmin;  Fiedler, Bjoern;  Von Tuempling, Wolf;  Read, Katie Alana;  Punjabi, Shalini;  Lewis, Alastair Charles;  Hopkins, James Roland;  Carpenter, Lucy Jane;  Peeken, Ilka;  Rixen, Tim;  Schulz-Bull, Detlef;  Monge, Maria Eugenia;  Mellouki, Abdelwahid;  George, Christian;  Stratmann, Frank;  Herrmann, Hartmut
收藏  |  浏览/下载:25/0  |  提交时间:2020/08/18
Significant methane ebullition from alpine permafrost rivers on the East Qinghai-Tibet Plateau 期刊论文
NATURE GEOSCIENCE, 2020, 13 (5)
作者:  Zhang, Liwei;  Xia, Xinghui;  Liu, Shaoda;  Zhang, Sibo;  Li, Siling;  Wang, Junfeng;  Wang, Gongqin;  Gao, Hui;  Zhang, Zhenrui;  Wang, Qingrui;  Wen, Wu;  Liu, Ran;  Yang, Zhifeng;  Stanley, Emily H.;  Raymond, Peter A.
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging 期刊论文
SCIENCE, 2019, 365 (6454) : 699-+
作者:  Abdelfattah, Ahmed S.;  Kawashima, Takashi;  Singh, Amrita;  Novak, Ondrej;  Liu, Hui;  Shuai, Yichun;  Huang, Yi-Chieh;  Campagnola, Luke;  Seeman, Stephanie C.;  Yu, Jianing;  Zheng, Jihong;  Grimm, Jonathan B.;  Patel, Ronak;  Friedrich, Johannes;  Mensh, Brett D.;  Paninski, Liam;  Macklin, John J.;  Murphy, Gabe J.;  Podgorski, Kaspar;  Lin, Bei-Jung;  Chen, Tsai-Wen;  Turner, Glenn C.;  Liu, Zhe;  Koyama, Minoru;  Svoboda, Karel;  Ahrens, Misha B.;  Lavis, Luke D.;  Schreiter, Eric R.
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
Population exposed to drought under the 1.5 degrees C and 2.0 degrees C warming in the Indus River Basin (vol 218, pg 296, 2019) 期刊论文
ATMOSPHERIC RESEARCH, 2019, 222: 172-172
作者:  Wen, Shanshan;  Wang, Anqian;  Tao, Hui;  Malik, Khalid;  Huang, Jinlong;  Zhai, Jianqing;  Jing, Cheng;  Rasul, Ghulam;  Su, Buda
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/26
Genetic basis of ruminant headgear and rapid antler regeneration 期刊论文
SCIENCE, 2019, 364 (6446) : 1153-+
作者:  Wang, Yu;  Zhang, Chenzhou;  Wang, Nini;  Li, Zhipeng;  Heller, Rasmus;  Liu, Rong;  Zhao, Yue;  Han, Jiangang;  Pan, Xiangyu;  Zheng, Zhuqing;  Dai, Xueqin;  Chen, Ceshi;  Dou, Mingle;  Peng, Shujun;  Chen, Xianqing;  Liu, Jing;  Li, Ming;  Wang, Kun;  Liu, Chang;  Lin, Zeshan;  Chen, Lei;  Hao, Fei;  Zhu, Wenbo;  Song, Chengchuang;  Zhao, Chen;  Zheng, Chengli;  Wang, Jianming;  Hu, Shengwei;  Li, Cunyuan;  Yang, Hui;  Jiang, Lin;  Li, Guangyu;  Liu, Mingjun;  Sonstegard, Tad S.;  Zhang, Guojie;  Jiang, Yu;  Wang, Wen;  Qiu, Qiang
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27