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Multiple transpolar auroral arcs reveal insight about coupling processes in the Earth's magnetotail 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (28) : 16193-16198
作者:  Zhang, Qing-He;  Zhang, Yong-Liang;  Wang, Chi;  Lockwood, Michael;  Yang, Hui-Gen;  Tang, Bin-Bin;  Xing, Zan-Yang;  Oksavik, Kjellmar;  Lyons, Larry R.;  Ma, Yu-Zhang;  Zong, Qiu-Gang;  Moen, Joran Idar;  Xia, Li-Dong
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/06
aurora  solar-terrestrial interaction  magnetosphere  polar ionosphere  transpolar auroral arcs  
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Chiral Majorana fermion modes in a quantum anomalous Hall insulator-superconductor structure 期刊论文
SCIENCE, 2017, 357 (6348) : 294-299
作者:  He, Qing Lin;  Pan, Lei;  Stern, Alexander L.;  Burks, Edward C.;  Che, Xiaoyu;  Yin, Gen;  Wang, Jing;  Lian, Biao;  Zhou, Quan;  Choi, Eun Sang;  Murata, Koichi;  Kou, Xufeng;  Chen, Zhijie;  Nie, Tianxiao;  Shao, Qiming;  Fan, Yabin;  Zhang, Shou-Cheng;  Liu, Kai;  Xia, Jing;  Wang, Kang L.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Bug mapping and fitness testing of chemically synthesized chromosome X 期刊论文
SCIENCE, 2017, 355 (6329)
作者:  Wu, Yi;  Li, Bing-Zhi;  Zhao, Meng;  Mitchell, Leslie A.;  Xie, Ze-Xiong;  Lin, Qiu-Hui;  Wang, Xia;  Xiao, Wen-Hai;  Wang, Ying;  Zhou, Xiao;  Liu, Hong;  Li, Xia;  Ding, Ming-Zhu;  Liu, Duo;  Zhang, Lu;  Liu, Bao-Li;  Wu, Xiao-Le;  Li, Fei-Fei;  Dong, Xiu-Tao;  Jia, Bin;  Zhang, Wen-Zheng;  Jiang, Guo-Zhen;  Liu, Yue;  Bai, Xue;  Song, Tian-Qing;  Chen, Yan;  Zhou, Si-Jie;  Zhu, Rui-Ying;  Gao, Feng;  Kuang, Zheng;  Wang, Xuya;  Shen, Michael;  Yang, Kun;  Stracquadanio, Giovanni;  Richardson, Sarah M.;  Lin, Yicong;  Wang, Lihui;  Walker, Roy;  Luo, Yisha;  Ma, Ping-Sheng;  Yang, Huanming;  Cai, Yizhi;  Dai, Junbiao;  Bader, Joel S.;  Boeke, Jef D.;  Yuan, Ying-Jin
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/27