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An improved D8-LTD for the extraction of total contributing area (TCA) by adopting the strategies of path independency and local dispersion 期刊论文
Water Resources Research, 2022
作者:  Zhenya Li;  Pengfei Shi;  Tao Yang;  Chao Wang;  Bin Yong;  Ying Song
收藏  |  浏览/下载:14/0  |  提交时间:2022/02/16
Hydraulic prediction of drought-induced plant dieback and top-kill depends on leaf habit and growth form 期刊论文
Ecology Letters, 2021
作者:  Ya-Jun Chen;  Brendan Choat;  Frank Sterck;  Phisamai Maenpuen;  Masatoshi Katabuchi;  Shu-Bin Zhang;  Kyle W. Tomlinson;  Rafael S. Oliveira;  Yong-Jiang Zhang;  Jing-Xian Shen;  Kun-Fang Cao;  Steven Jansen
收藏  |  浏览/下载:15/0  |  提交时间:2021/08/25
Assessing the precision of total contributing area (TCA) estimated by flow direction algorithms based on the analytical solution of theoretical TCA on synthetic surfaces 期刊论文
Water Resources Research, 2021
作者:  Zhenya Li;  Tao Yang;  Chao Wang;  Pengfei Shi;  Bin Yong;  Ying Song
收藏  |  浏览/下载:11/0  |  提交时间:2021/03/17
Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair 期刊论文
Science, 2021
作者:  Lingjuan He;  Wenjuan Pu;  Xiuxiu Liu;  Zhenqian Zhang;  Maoying Han;  Yi Li;  Xiuzhen Huang;  Ximeng Han;  Yan Li;  Kuo Liu;  Mengyang Shi;  Liang Lai;  Ruilin Sun;  Qing-Dong Wang;  Yong Ji;  Jan S. Tchorz;  Bin Zhou
收藏  |  浏览/下载:37/0  |  提交时间:2021/03/02
A space hurricane over the Earth鈥檚 polar ionosphere 期刊论文
Nature Communications, 2021
作者:  Qing-He Zhang;  Yong-Liang Zhang;  Chi Wang;  Kjellmar Oksavik;  Larry R. Lyons;  Michael Lockwood;  Hui-Gen Yang;  Bin-Bin Tang;  ;  ran Idar Moen;  Zan-Yang Xing;  Yu-Zhang Ma;  Xiang-Yu Wang;  Ya-Fei Ning;  Li-Dong Xia
收藏  |  浏览/下载:15/0  |  提交时间:2021/03/02
Near-surface softening and healing in eastern Honshu associated with the 2011 magnitude-9 Tohoku-Oki Earthquake 期刊论文
Nature Communications, 2021
作者:  Su-Yang Wang;  Hai-Yang Zhuang;  Hao Zhang;  Hong-Jun He;  Wei-Ping Jiang;  Er-Lei Yao;  Bin Ruan;  Yong-Xin Wu;  Yu Miao
收藏  |  浏览/下载:9/0  |  提交时间:2021/03/02
High-entropy-stabilized chalcogenides with high thermoelectric performance 期刊论文
Science, 2021
作者:  Binbin Jiang;  Yong Yu;  Juan Cui;  Xixi Liu;  Lin Xie;  Jincheng Liao;  Qihao Zhang;  Yi Huang;  Shoucong Ning;  Baohai Jia;  Bin Zhu;  Shengqiang Bai;  Lidong Chen;  Stephen J. Pennycook;  Jiaqing He
收藏  |  浏览/下载:13/0  |  提交时间:2021/02/22
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage (vol 551, pg 629, 2017) 期刊论文
NATURE, 2020, 580 (7802) : E5-E5
作者:  Lu, Zhihao;  Zou, Jianling;  Li, Shuang;  Topper, Michael J.;  Tao, Yong;  Zhang, Hao;  Jiao, Xi;  Xie, Wenbing;  Kong, Xiangqian;  Vaz, Michelle;  Li, Huili;  Cai, Yi;  Xia, Limin;  Huang, Peng;  Rodgers, Kristen;  Lee, Beverly;  Riemer, Joanne B.;  Day, Chi-Ping;  Yen, Ray-Whay Chiu;  Cui, Ying;  Wang, Yujiao;  Wang, Yanni;  Zhang, Weiqiang;  Easwaran, Hariharan;  Hulbert, Alicia;  Kim, KiBem;  Juergens, Rosalyn A.;  Yang, Stephen C.;  Battafarano, Richard J.;  Bush, Errol L.;  Broderick, Stephen R.;  Cattaneo, Stephen M.;  Brahmer, Julie R.;  Rudin, Charles M.;  Wrangle, John;  Mei, Yuping;  Kim, Young J.;  Zhang, Bin;  Wang, Ken Kang-Hsin;  Forde, Patrick M.;  Margolick, Joseph B.;  Nelkin, Barry D.;  Zahnow, Cynthia A.;  Pardoll, Drew M.;  Housseau, Franck;  Baylin, Stephen B.;  Shen, Lin;  Brock, Malcolm V.
收藏  |  浏览/下载:27/0  |  提交时间:2020/07/03