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Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil 期刊论文
Science, 2021
作者:  Nuno R. Faria;  Thomas A. Mellan;  Charles Whittaker;  Ingra M. Claro;  Darlan da S. Candido;  Swapnil Mishra;  Myuki A. E. Crispim;  Flavia C. S. Sales;  Iwona Hawryluk;  John T. McCrone;  Ruben J. G. Hulswit;  Lucas A. M. Franco;  Mariana S. Ramundo;  Jaqueline G. de Jesus;  Pamela S. Andrade;  Thais M. Coletti;  Giulia M. Ferreira;  Camila A. M. Silva;  Erika R. Manuli;  Rafael H. M. Pereira;  Pedro S. Peixoto;  Moritz U. G. Kraemer;  Nelson Gaburo;  Cecilia da C. Camilo;  Henrique Hoeltgebaum;  William M. Souza;  Esmenia C. Rocha;  Leandro M. de Souza;  Mariana C. de Pinho;  Leonardo J. T. Araujo;  Frederico S. V. Malta;  Aline B. de Lima;  Joice do P. Silva;  Danielle A. G. Zauli;  Alessandro C. de S. Ferreira;  Ricardo P. Schnekenberg;  Daniel J. Laydon;  Patrick G. T. Walker;  Hannah M. Schlüter;  Ana L. P. dos Santos;  Maria S. Vidal;  Valentina S. Del Caro;  Rosinaldo M. F. Filho;  Helem M. dos Santos;  Renato S. Aguiar;  José L. Proença-Modena;  Bruce Nelson;  James A. Hay;  Mélodie Monod;  Xenia Miscouridou;  Helen Coupland;  Raphael Sonabend;  Michaela Vollmer;  Axel Gandy;  Carlos A. Prete;  Vitor H. Nascimento;  Marc A. Suchard;  Thomas A. Bowden;  Sergei L. K. Pond;  Chieh-Hsi Wu;  Oliver Ratmann;  Neil M. Ferguson;  Christopher Dye;  Nick J. Loman;  Philippe Lemey;  Andrew Rambaut;  Nelson A. Fraiji;  Maria do P. S. S. Carvalho;  Oliver G. Pybus;  Seth Flaxman;  Samir Bhatt;  Ester C. Sabino
收藏  |  浏览/下载:13/0  |  提交时间:2021/06/07
Ecosystem transpiration and evaporation: Insights from three water flux partitioning methods across FLUXNET sites 期刊论文
Global Change Biology, 2020
作者:  Jacob A. Nelson;  Oscar Pé;  rez‐;  Priego;  Sha Zhou;  Rafael Poyatos;  Yao Zhang;  Peter D. Blanken;  Teresa E. Gimeno;  Georg Wohlfahrt;  Ankur R. Desai;  Beniamino Gioli;  Jean‐;  Marc Limousin;  Damien Bonal;  Eugé;  nie Paul‐;  Limoges;  Russell L. Scott;  Andrej Varlagin;  Kathrin Fuchs;  Leonardo Montagnani;  Sebastian Wolf;  Nicolas Delpierre;  Daniel Berveiller;  Mana Gharun;  Luca Belelli Marchesini;  Damiano Gianelle;  Ladislav Š;  igut;  Ivan Mammarella;  Lukas Siebicke;  T. Andrew Black;  Alexander Knohl;  Lukas Hö;  rtnagl;  Vincenzo Magliulo;  Simon Besnard;  Ulrich Weber;  Nuno Carvalhais;  Mirco Migliavacca;  Markus Reichstein;  Martin Jung
收藏  |  浏览/下载:13/0  |  提交时间:2020/10/12
Evolution and epidemic spread of SARS-CoV-2 in Brazil 期刊论文
Science, 2020
作者:  Darlan S. Candido;  Ingra M. Claro;  Jaqueline G. de Jesus;  William M. Souza;  Filipe R. R. Moreira;  Simon Dellicour;  Thomas A. Mellan;  Louis du Plessis;  Rafael H. M. Pereira;  Flavia C. S. Sales;  Erika R. Manuli;  Julien Thézé;  Luiz Almeida;  Mariane T. Menezes;  Carolina M. Voloch;  Marcilio J. Fumagalli;  Thaís M. Coletti;  Camila A. M. da Silva;  Mariana S. Ramundo;  Mariene R. Amorim;  Henrique H. Hoeltgebaum;  Swapnil Mishra;  Mandev S. Gill;  Luiz M. Carvalho;  Lewis F. Buss;  Carlos A. Prete;  Jordan Ashworth;  Helder I. Nakaya;  Pedro S. Peixoto;  Oliver J. Brady;  Samuel M. Nicholls;  Amilcar Tanuri;  Átila D. Rossi;  Carlos K. V. Braga;  Alexandra L. Gerber;  Ana Paula de C. Guimarães;  Nelson Gaburo;  Cecila Salete Alencar;  Alessandro C. S. Ferreira;  Cristiano X. Lima;  José Eduardo Levi;  Celso Granato;  Giulia M. Ferreira;  Ronaldo S. Francisco;  Fabiana Granja;  Marcia T. Garcia;  Maria Luiza Moretti;  Mauricio W. Perroud;  Terezinha M. P. P. Castiñeiras;  Carolina S. Lazari;  Sarah C. Hill;  Andreza Aruska de Souza Santos;  Camila L. Simeoni;  Julia Forato;  Andrei C. Sposito;  Angelica Z. Schreiber;  Magnun N. N. Santos;  Camila Zolini de Sá;  Renan P. Souza;  Luciana C. Resende-Moreira;  Mauro M. Teixeira;  Josy Hubner;  Patricia A. F. Leme;  Rennan G. Moreira;  Maurício L. Nogueira;  Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology Genomic Network;  Neil M. Ferguson;  Silvia F. Costa;  José Luiz Proenca-Modena;  Ana Tereza R. Vasconcelos;  Samir Bhatt;  Philippe Lemey;  Chieh-Hsi Wu;  Andrew Rambaut;  Nick J. Loman;  Renato S. Aguiar;  Oliver G. Pybus;  Ester C. Sabino;  Nuno Rodrigues Faria
收藏  |  浏览/下载:13/0  |  提交时间:2020/09/08
Experimental demonstration of memory-enhanced quantum communication 期刊论文
NATURE, 2020
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

The ability to communicate quantum information over long distances is of central importance in quantum science and engineering(1). Although some applications of quantum communication such as secure quantum key distribution(2,3) are already being successfully deployed(4-7), their range is currently limited by photon losses and cannot be extended using straightforward measure-and-repeat strategies without compromising unconditional security(8). Alternatively, quantum repeaters(9), which utilize intermediate quantum memory nodes and error correction techniques, can extend the range of quantum channels. However, their implementation remains an outstanding challenge(10-16), requiring a combination of efficient and high-fidelity quantum memories, gate operations, and measurements. Here we use a single solid-state spin memory integrated in a nanophotonic diamond resonator(17-19) to implement asynchronous photonic Bell-state measurements, which are a key component of quantum repeaters. In a proof-of-principle experiment, we demonstrate high-fidelity operation that effectively enables quantum communication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz clock speeds. These results represent a crucial step towards practical quantum repeaters and large-scale quantum networks(20,21).


A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.


  
Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy 期刊论文
NATURE, 2020, 578 (7794) : 273-+
作者:  Senior, Andrew W.;  Evans, Richard;  Jumper, John;  Kirkpatrick, James;  Sifre, Laurent;  Green, Tim;  Qin, Chongli;  Zidek, Augustin;  Nelson, Alexander W. R.;  Bridgland, Alex;  Penedones, Hugo;  Petersen, Stig;  Simonyan, Karen;  Crossan, Steve;  Kohli, Pushmeet;  Jones, David T.;  Silver, David;  Kavukcuoglu, Koray;  Hassabis, Demis
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/03

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of alpha-synuclein, including Parkinson'  s disease, dementia with Lewy bodies and multiple system atrophy(1). Clinically, it is challenging to differentiate Parkinson'  s disease and multiple system atrophy, especially at the early stages of disease(2). Aggregates of alpha-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of alpha-synuclein that can self-propagate and spread from cell to cell(3-6). Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect alpha-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity(7,8). Here we show that the alpha-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson'  s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%. We used a combination of biochemical, biophysical and biological methods to analyse the product of alpha-synuclein-PMCA, and found that the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid could be used to readily distinguish between Parkinson'  s disease and multiple system atrophy. We also found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar to those of aggregates that were amplified from the brain. These findings suggest that alpha-synuclein aggregates that are associated with Parkinson'  s disease and multiple system atrophy correspond to different conformational strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA. Our results may help to improve our understanding of the mechanism of alpha-synuclein misfolding and the structures of the aggregates that are implicated in different synucleinopathies, and may also enable the development of a biochemical assay to discriminate between Parkinson'  s disease and multiple system atrophy.


Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson'  s disease and patients with multiple system atrophy on the basis of the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid.


  
Ecological effects and effectiveness of silvicultural restoration treatments in whitebark pine forests 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 429: 534-548
作者:  Maher, Colin T.;  Nelson, Cara R.;  Larson, Andrew J.;  Sala, Anna
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Pinus albicaulis  Growth response  Regeneration  Seedling recruitment  White pine blister rust, mountain pine beetle  
Integrated genomic and molecular characterization of cervical cancer 期刊论文
NATURE, 2017, 543 (7645) : 378-+
作者:  Burk, Robert D.;  Chen, Zigui;  Saller, Charles;  Tarvin, Katherine;  Carvalho, Andre L.;  Scapulatempo-Neto, Cristovam;  Silveira, Henrique C.;  Fregnani, Jose H.;  Creighton, Chad J.;  Anderson, Matthew L.;  Castro, Patricia;  Wang, Sophia S.;  Yau, Christina;  Benz, Christopher;  Robertson, A. Gordon;  Mungall, Karen;  Lim, Lynette;  Bowlby, Reanne;  Sadeghi, Sara;  Brooks, Denise;  Sipahimalani, Payal;  Mar, Richard;  Ally, Adrian;  Clarke, Amanda;  Mungall, Andrew J.;  Tam, Angela;  Lee, Darlene;  Chuah, Eric;  Schein, Jacqueline E.;  Tse, Kane;  Kasaian, Katayoon;  Ma, Yussanne;  Marra, Marco A.;  Mayo, Michael;  Balasundaram, Miruna;  Thiessen, Nina;  Dhalla, Noreen;  Carlsen, Rebecca;  Moore, Richard A.;  Holt, Robert A.;  Jones, Steven J. M.;  Wong, Tina;  Pantazi, Angeliki;  Parfenov, Michael;  Kucherlapati, Raju;  Hadjipanayis, Angela;  Seidman, Jonathan;  Kucherlapati, Melanie;  Ren, Xiaojia;  Xu, Andrew W.;  Yang, Lixing;  Park, Peter J.;  Lee, Semin;  Rabeno, Brenda;  Huelsenbeck-Dill, Lori;  Borowsky, Mark;  Cadungog, Mark;  Iacocca, Mary;  Petrelli, Nicholas;  Swanson, Patricia;  Ojesina, Akinyemi I.;  Le, Xuan;  Sandusky, George;  Adebamowo, Sally N.;  Akeredolu, Teniola;  Adebamowo, Clement;  Reynolds, Sheila M.;  Shmulevich, Ilya;  Shelton, Candace;  Crain, Daniel;  Mallery, David;  Curley, Erin;  Gardner, Johanna;  Penny, Robert;  Morris, Scott;  Shelton, Troy;  Liu, Jia;  Lolla, Laxmi;  Chudamani, Sudha;  Wu, Ye;  Birrer, Michael;  McLellan, Michael D.;  Bailey, Matthew H.;  Miller, Christopher A.;  Wyczalkowski, Matthew A.;  Fulton, Robert S.;  Fronick, Catrina C.;  Lu, Charles;  Mardis, Elaine R.;  Appelbaum, Elizabeth L.;  Schmidt, Heather K.;  Fulton, Lucinda A.;  Cordes, Matthew G.;  Li, Tiandao;  Ding, Li;  Wilson, Richard K.;  Rader, Janet S.;  Behmaram, Behnaz;  Uyar, Denise;  Bradley, William;  Wrangle, John;  Pastore, Alessandro;  Levine, Douglas A.;  Dao, Fanny;  Gao, Jianjiong;  Schultz, Nikolaus;  Sander, Chris;  Ladanyi, Marc;  Einstein, Mark;  Teeter, Randall;  Benz, Stephen;  Wentzensen, Nicolas;  Felau, Ina;  Zenklusen, Jean C.;  Bodelon, Clara;  Demchok, John A.;  Yang, Liming;  Sheth, Margi;  Ferguson, Martin L.;  Tarnuzzer, Roy;  Yang, Hannah;  Schiffman, Mark;  Zhang, Jiashan;  Wang, Zhining;  Davidsen, Tanja;  Olaniyan, Olayinka;  Hutter, Carolyn M.;  Sofia, Heidi J.;  Gordenin, Dmitry A.;  Chan, Kin;  Roberts, Steven A.;  Klimczak, Leszek J.;  Van Waes, Carter;  Chen, Zhong;  Saleh, Anthony D.;  Cheng, Hui;  Parfitt, Jeremy;  Bartlett, John;  Albert, Monique;  Arnaout, Angel;  Sekhon, Harman;  Gilbert, Sebastien;  Peto, Myron;  Myers, Jerome;  Harr, Jodi;  Eckman, John;  Bergsten, Julie;  Tucker, Kelinda;  Zach, Leigh Anne;  Karlan, Beth Y.;  Lester, Jenny;  Orsulic, Sandra;  Sun, Qiang;  Naresh, Rashi;  Pihl, Todd;  Wan, Yunhu;  Zaren, Howard;  Sapp, Jennifer;  Miller, Judy;  Drwiega, Paul;  Ojesina, Akinyemi I.;  Murray, Bradley A.;  Zhang, Hailei;  Cherniack, Andrew D.;  Sougnez, Carrie;  Pedamallu, Chandra Sekhar;  Lichtenstein, Lee;  Meyerson, Matthew;  Noble, Michael S.;  Heiman, David I.;  Voet, Doug;  Getz, Gad;  Saksena, Gordon;  Kim, Jaegil;  Shih, Juliann;  Cho, Juok;  Lawrence, Michael S.;  Gehlenborg, Nils;  Lin, Pei;  Beroukhim, Rameen;  Frazer, Scott;  Gabriel, Stacey B.;  Schumacher, Steven E.;  Leraas, Kristen M.;  Lichtenberg, Tara M.;  Zmuda, Erik;  Bowen, Jay;  Frick, Jessica;  Gastier-Foster, Julie M.;  Wise, Lisa;  Gerken, Mark;  Ramirez, Nilsa C.;  Danilova, Ludmila;  Cope, Leslie;  Baylin, Stephen B.;  Salvesen, Helga B.;  Vellano, Christopher P.;  Ju, Zhenlin;  Diao, Lixia;  Zhao, Hao;  Chong, Zechen;  Ryan, Michael C.;  Martinez-Ledesma, Emmanuel;  Verhaak, Roeland G.;  Byers, Lauren Averett;  Yuan, Yuan;  Chen, Ken;  Ling, Shiyun;  Mills, Gordon B.;  Lu, Yiling;  Akbani, Rehan;  Seth, Sahil;  Liang, Han;  Wang, Jing;  Han, Leng;  Weinstein, John N.;  Bristow, Christopher A.;  Zhang, Wei;  Mahadeshwar, Harshad S.;  Sun, Huandong;  Tang, Jiabin;  Zhang, Jianhua;  Song, Xingzhi;  Protopopov, Alexei;  Shaw, Kenna R. Mills;  Chin, Lynda;  Olabode, Oluwole;  Ojesina, Akinyemi I.;  DiSaia, Philip;  Radenbaugh, Amie;  Haussler, David;  Zhu, Jingchun;  Stuart, Josh;  Chalise, Prabhakar;  Koestler, Devin;  Fridley, Brooke L.;  Godwin, Andrew K.;  Madan, Rashna;  Ciriello, Giovanni;  Martinez, Cathleen;  Higgins, Kelly;  Bocklage, Therese;  Auman, J. Todd;  Perou, Charles M.;  Tan, Donghui;  Parker, Joel S.;  Hoadley, Katherine A.;  Wilkerson, Matthew D.;  Mieczkowski, Piotr A.;  Skelly, Tara;  Veluvolu, Umadevi;  Hayes, D. Neil;  Rathmell, W. Kimryn;  Hoyle, Alan P.;  Simons, Janae V.;  Wu, Junyuan;  Mose, Lisle E.;  Soloway, Matthew G.;  Balu, Saianand;  Meng, Shaowu;  Jefferys, Stuart R.;  Bodenheimer, Tom;  Shi, Yan;  Roach, Jeffrey;  Thorne, Leigh B.;  Boice, Lori;  Huang, Mei;  Jones, Corbin D.;  Zuna, Rosemary;  Walker, Joan;  Gunderson, Camille;  Snowbarger, Carie;  Brown, David;  Moxley, Katherine;  Moore, Kathleen;  Andrade, Kelsi;  Landrum, Lisa;  Mannel, Robert;  McMeekin, Scott;  Johnson, Starla;  Nelson, Tina;  Elishaev, Esther;  Dhir, Rajiv;  Edwards, Robert;  Bhargava, Rohit;  Tiezzi, Daniel G.;  Andrade, Jurandyr M.;  Noushmehr, Houtan;  Carlotti, Carlos Gilberto, Jr.;  Tirapelli, Daniela Pretti da Cunha;  Weisenberger, Daniel J.;  Van Den Berg, David J.;  Maglinte, Dennis T.;  Bootwalla, Moiz S.;  Lai, Phillip H.;  Triche, Timothy, Jr.;  Swisher, Elizabeth M.;  Agnew, Kathy J.;  Shelley, Carl Simon;  Laird, Peter W.;  Schwarz, Julie;  Grigsby, Perry;  Mutch, David
收藏  |  浏览/下载:15/0  |  提交时间:2019/04/09