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联合国欧洲经济委员会发布可持续智慧城市报告 快报文章
资源环境快报,2020年第24期
作者:  牛艺博
Microsoft Word(19Kb)  |  收藏  |  浏览/下载:468/1  |  提交时间:2020/12/31
Cities  Sustainable  People-Smart  
全球范围内自然对人类的大部分贡献都有所减少 快报文章
资源环境快报,2020年第24期
作者:  裴惠娟
Microsoft Word(15Kb)  |  收藏  |  浏览/下载:460/0  |  提交时间:2020/12/31
Nature's Contributions to People  Global Trends  Decline  
Map clusters of diseases to tackle multimorbidity 期刊论文
NATURE, 2020, 579 (7800) : 494-496
作者:  Abbott, Alison
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

Many people now have two or more diseases at once. It is time to rethink funding, research, publishing, training and treatment for this growing problem.


Many people now have two or more diseases at once. It is time to rethink funding, research, publishing, training and treatment for this growing problem.


  
CHLOROQUINE HYPE DERAILS CORONAVIRUS DRUG TRIALS 期刊论文
NATURE, 2020, 580 (7805) : 573-573
作者:  Hu, Minjie;  Zheng, Xiaobin;  Fan, Chen-Ming;  Zheng, Yixian
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

With politicians touting the potential benefits of malaria drugs to fight COVID-19, some people are turning away from clinical trials of other therapies.


With politicians touting the potential benefits of malaria drugs to fight COVID-19, some people are turning away from clinical trials of other therapies.


  
联合国报告关注森林与生物多样性保护及人类可持续发展 快报文章
资源环境快报,2020年第11期
作者:  董利苹
Microsoft Word(14Kb)  |  收藏  |  浏览/下载:364/0  |  提交时间:2020/06/16
Forests  Biodiversity  People  
HOMOGENEITY IN THE UK 期刊论文
NATURE, 2020, 579 (7800) : 622-622
作者:  Bell, Avery Davis;  Mello, Curtis J.;  Nemesh, James;  Brumbaugh, Sara A.;  Wysoker, Alec;  McCarroll, Steven A.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Men outnumber and out-earn women, and white people take up more posts and are more likely to be in the highest pay grades than people from minority ethnic groups.


Men outnumber and out-earn women, and white people take up more posts and are more likely to be in the highest pay grades than people from minority ethnic groups.


  
Scientists exposed to coronavirus wonder: why weren't we notified? 期刊论文
NATURE, 2020, 579 (7800) : 480-481
作者:  Subbaraman, Nidhi
收藏  |  浏览/下载:4/0  |  提交时间:2020/07/03

US authorities are failing to test people and notify their contacts, a cornerstone of outbreak response.


Scientists exposed to coronavirus: why weren'  t we notified? US authorities are failing to test people and notify their contacts, a cornerstone of outbreak response.


  
The steroid debate 期刊论文
NATURE, 2020, 581 (7807) : S12-S13
作者:  Pagel, Mark
收藏  |  浏览/下载:3/0  |  提交时间:2020/07/03

Many people with chronic obstructive pulmonary disease are given steroids despite a lack of evidence underpinning their use.


Many people with chronic obstructive pulmonary disease are given steroids despite a lack of evidence underpinning their use.


  
Redefining a disease 期刊论文
NATURE, 2020, 581 (7807) : S4-S6
作者:  Castelvecchi, Davide
收藏  |  浏览/下载:1/0  |  提交时间:2020/07/03

Many people with symptoms of chronic obstructive pulmonary disease don'  t meet the criteria for diagnosis. The field is grappling with how to define and treat these patients.


Many people with symptoms of chronic obstructive pulmonary disease don'  t meet the criteria for diagnosis. The field is grappling with how to define and treat these patients.


  
Sialylation of immunoglobulin E is a determinant of allergic pathogenicity 期刊论文
NATURE, 2020, 582 (7811) : 265-+
作者:  Abdul-Masih, Michael;  Banyard, Gareth;  Bodensteiner, Julia;  Bordier, Emma;  Bowman, Dominic M.;  Dsilva, Karan;  Fabry, Matthias;  Hawcroft, Calum;  Mahy, Laurent;  Marchant, Pablo;  Raskin, Gert;  Reggiani, Maddalena;  Shenar, Tomer;  Tkachenko, Andrew;  Van Winckel, Hans;  Vermeylen, Lore;  Sana, Hugues
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03

A specific type of glycosylation-sialylation-is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.


Approximately one-third of the world'  s population suffers from allergies(1). Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including histamine(2). Although IgE is absolutely required for allergies, it is not understood why total and allergen-specific IgE concentrations do not reproducibly correlate with allergic disease(3-5). It is well-established that glycosylation of IgG dictates its effector function and has disease-specific patterns. However, whether IgE glycans differ in disease states or affect biological activity is completely unknown(6). Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals with a peanut allergy and from non-atopic individuals without allergies. Our analysis reveals an increase in sialic acid content on total IgE from individuals with a peanut allergy compared with non-atopic individuals. Removal of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional models of allergic disease. Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enzyme targeted towards the IgE receptor Fc epsilon RI, and administering asialylated IgE-markedly reduce anaphylaxis. Together, these results establish IgE glycosylation, and specifically sialylation, as an important regulator of allergic disease.