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RGF1 controls root meristem size through ROS signalling 期刊论文
NATURE, 2020, 577 (7788) : 85-+
作者:  Yamada, Masashi;  Han, Xinwei;  Benfey, Philip N.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/03

The stem cell niche and the size of the root meristem in plants are maintained by intercellular interactions and signalling networks involving a peptide hormone, root meristem growth factor 1 (RGF1)(1). Understanding how RGF1 regulates the development of the root meristem is essential for understanding stem cell function. Although five receptors for RGF1 have been identified(2-4), the downstream signalling mechanism remains unknown. Here we report a series of signalling events that follow RGF1 activity. We find that the RGF1-receptor pathway controls the distribution of reactive oxygen species (ROS) along the developmental zones of the Arabidopsis root. We identify a previously uncharacterized transcription factor, RGF1-INDUCIBLE TRANSCRIPTION FACTOR 1 (RITF1), that has a central role in mediating RGF1 signalling. Manipulating RITF1 expression leads to the redistribution of ROS along the root developmental zones. Changes in ROS distribution in turn enhance the stability of the PLETHORA2 protein, a master regulator of root stem cells. Our results thus clearly depict a signalling cascade that is initiated by RGF1, linking this peptide to mechanisms that regulate ROS.


  
Patterns of somatic structural variation in human cancer genomes 期刊论文
NATURE, 2020, 578 (7793) : 112-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes(1-7). Here we develop methods to group, classify and describe somatic structural variants, using data from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumour types(8). Sixteen signatures of structural variation emerged. Deletions have a multimodal size distribution, assort unevenly across tumour types and patients, are enriched in late-replicating regions and correlate with inversions. Tandem duplications also have a multimodal size distribution, but are enriched in early-replicating regions-as are unbalanced translocations. Replication-based mechanisms of rearrangement generate varied chromosomal structures with low-level copy-number gains and frequent inverted rearrangements. One prominent structure consists of 2-7 templates copied from distinct regions of the genome strung together within one locus. Such cycles of templated insertions correlate with tandem duplications, and-in liver cancerfrequently activate the telomerase gene TERT. A wide variety of rearrangement processes are active in cancer, which generate complex configurations of the genome upon which selection can act.


  
An orbital water-ice cycle on comet 67P from colour changes 期刊论文
NATURE, 2020, 578 (7793) : 49-+
作者:  Oh, Myoung Hwan;  Cho, Min Gee;  Chung, Dong Young;  Park, Inchul;  Kwon, Youngwook Paul;  Ophus, Colin;  Kim, Dokyoon;  Kim, Min Gyu;  Jeong, Beomgyun;  Gu, X. Wendy;  Jo, Jinwoung;  Yoo, Ji Mun;  Hong, Jaeyoung;  McMains, Sara;  Kang, Kisuk;  Sung, Yung-Eun;  Alivisatos, A. Paul;  Hyeon, Taeghwan
收藏  |  浏览/下载:52/0  |  提交时间:2020/07/03

Solar heating of a cometary surface provides the energy necessary to sustain gaseous activity, through which dust is removed(1,2). In this dynamical environment, both the coma(3,4) and the nucleus(5,6) evolve during the orbit, changing their physical and compositional properties. The environment around an active nucleus is populated by dust grains with complex and variegated shapes(7), lifted and diffused by gases freed from the sublimation of surface ices(8,9). The visible colour of dust particles is highly variable: carbonaceous organic material-rich grains(10) appear red while magnesium silicate-rich(11,12) and water-ice-rich(13,14) grains appear blue, with some dependence on grain size distribution, viewing geometry, activity level and comet family type. We know that local colour changes are associated with grain size variations, such as in the bluer jets made of submicrometre grains on comet Hale-Bopp(15) or in the fragmented grains in the coma(16) of C/1999 S4 (LINEAR). Apart from grain size, composition also influences the coma'  s colour response, because transparent volatiles can introduce a substantial blueing in scattered light, as observed in the dust particles ejected after the collision of the Deep Impact probe with comet 9P/Tempel 1(17). Here we report observations of two opposite seasonal colour cycles in the coma and on the surface of comet 67P/Churyumov-Gerasimenko through its perihelion passage(18). Spectral analysis indicates an enrichment of submicrometre grains made of organic material and amorphous carbon in the coma, causing reddening during the passage. At the same time, the progressive removal of dust from the nucleus causes the exposure of more pristine and bluish icy layers on the surface. Far from the Sun, we find that the abundance of water ice on the nucleus is reduced owing to redeposition of dust and dehydration of the surface layer while the coma becomes less red.


  
The global decline of freshwater megafauna 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (11) : 3883-3892
作者:  He, Fengzhi;  Zarfl, Christiane;  Bremerich, Vanessa;  David, Jonathan N. W.;  Hogan, Zeb;  Kalinkat, Gregor;  Tockner, Klement;  Jaehnig, Sonja C.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
biodiversity  conservation  distribution  extinction  population  range contraction  size  vertebrate  
Stokes-Brinkman Flow Simulation Based on 3-D mu-CT Images of Porous Rock Using Grayscale Pore Voxel Permeability 期刊论文
WATER RESOURCES RESEARCH, 2019, 55 (5) : 4448-4464
作者:  Kang, Dong Hun;  Yang, Eomzi;  Yun, Tae Sup
收藏  |  浏览/下载:4/0  |  提交时间:2019/11/26
Brinkman force lattice Boltzmann method  gray pore  voxel permeability  pore size distribution  permeability  
Environmental filtering explains a U-shape latitudinal pattern in regional beta-deviation for eastern North American trees 期刊论文
ECOLOGY LETTERS, 2019, 22 (2) : 284-291
作者:  Xing, Dingliang;  He, Fangliang
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Beta diversity  community assembly  environmental filtering  metacommunity  range size  species abundance distribution  species aggregation  
Ticket to spawn: Combining economic and genetic data to evaluate the effect of climate and demographic structure on spawning distribution in Atlantic cod 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (1) : 134-143
作者:  Langangen, Oystein;  Farber, Leonie;  Stige, Leif C.;  Diekert, Florian K.;  Barth, Julia M., I;  Matschiner, Michael;  Berg, Paul R.;  Star, Bastiaan;  Stenseth, Nils Chr;  Jentoft, Sissel;  Durant, Joel M.
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
climate change  demography  economic data  genetic data  size truncation  spawning distribution  
Water Repellency Decreases Vapor Sorption of Clay Minerals 期刊论文
WATER RESOURCES RESEARCH, 2018, 54 (9) : 6114-6125
作者:  Chen, Jingjing;  Shang, Chao;  Eick, Matthew J.;  Stewart, Ryan D.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
hydrophobicity  isotherm  clays  zeta potential  particle size distribution  amphiphilic molecular structure  
Biodiversity and ecosystem functioning in food webs: the vertical diversity hypothesis 期刊论文
ECOLOGY LETTERS, 2018, 21 (1) : 9-20
作者:  Wang, Shaopeng;  Brose, Ulrich
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
allometry  complex food webs  ecological pyramids  nutrient supply  nutrient uptake  primary production  size distribution  trophic level  vertical diversity  
Non-additive effects of simulated heat waves and predators on prey phenotype and transgenerational phenotypic plasticity 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (11)
作者:  Sentis, Arnaud;  Hemptinne, Jean-Louis;  Brodeur, Jacques
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
aphid  body size  climate change  extreme temperatures  heat stress  ladybeetle  phenotypic plasticity  spatial distribution  trophic interactions  wing polyphenism