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Global patterns of forest autotrophic carbon fluxes 期刊论文
Global Change Biology, 2021
作者:  Rebecca Banbury Morgan;  Valentine Herrmann;  Norbert Kunert;  Ben Bond‐;  Lamberty;  Helene C. Muller‐;  Landau;  Kristina J. Anderson‐;  Teixeira
收藏  |  浏览/下载:25/0  |  提交时间:2021/03/29
Pervasive shifts in forest dynamics in a changing world 期刊论文
Science, 2020
作者:  Nate G. McDowell;  Craig D. Allen;  Kristina Anderson-Teixeira;  Brian H. Aukema;  Ben Bond-Lamberty;  Louise Chini;  James S. Clark;  Michael Dietze;  Charlotte Grossiord;  Adam Hanbury-Brown;  George C. Hurtt;  Robert B. Jackson;  Daniel J. Johnson;  Lara Kueppers;  Jeremy W. Lichstein;  Kiona Ogle;  Benjamin Poulter;  Thomas A. M. Pugh;  Rupert Seidl;  Monica G. Turner;  Maria Uriarte;  Anthony P. Walker;  Chonggang Xu
收藏  |  浏览/下载:33/0  |  提交时间:2020/06/01
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:74/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
CarbonShot: Federal Policy Options for Carbon Removal in the United States 科技报告
来源:World Resources Institute. 出版年: 2020
作者:  James Mulligan;  Alex Rudee;  Katie Lebling;  Kelly Levin;  James Anderson;  Ben Christensen
收藏  |  浏览/下载:24/0  |  提交时间:2020/05/27
Embryonal precursors of Wilms tumor 期刊论文
SCIENCE, 2019, 366 (6470) : 1247-+
作者:  Coorens, Tim H. H.;  Treger, Taryn D.;  Al-Saadi, Reem;  Moore, Luiza;  Tran, Maxine G. B.;  Mitchell, Thomas J.;  Tugnait, Suzanne;  Thevanesan, Christine;  Young, Matthew D.;  Oliver, Thomas R. W.;  Oostveen, Minou;  Collord, Grace;  Tarpey, Patrick S.;  Cagan, Alex;  Hooks, Yvette;  Brougham, Mark;  Reynolds, Ben C.;  Barone, Giuseppe;  Anderson, John;  Jorgensen, Mette;  Burke, G. A. Amos;  Visser, Johannes;  Nicholson, James C.;  Smeulders, Naima;  Mushtaq, Imran;  Stewart, Grant D.;  Campbell, Peter J.;  Wedge, David C.;  Martincorena, Inigo;  Rampling, Dyanne;  Hook, Liz;  Warren, Anne Y.;  Coleman, Nicholas;  Chowdhury, Tanzina;  Sebire, Neil;  Drost, Jarno;  Saeb-Parsy, Kourosh;  Stratton, Michael R.;  Straathof, Karin;  Pritchard-Jones, Kathy;  Behjati, Sam
收藏  |  浏览/下载:44/0  |  提交时间:2020/02/17
Onshore wind and the likelihood of planning acceptance: Learning from a Great Britain context 期刊论文
ENERGY POLICY, 2019, 128: 954-966
作者:  Harper, Michael;  Anderson, Ben;  James, Patrick A. B.;  Bahaj, AbuBakr S.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/26
Planning  Demographics  GIS  Great Britain  Logistic regression  
Explaining shifts in UK electricity demand using time use data from 1974 to 2014 期刊论文
ENERGY POLICY, 2018, 123: 544-557
作者:  Anderson, Ben;  Torriti, Jacopo
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
Electricity  Peak demand  Residential  Historical trends  Time use  UK  
Prediction from Weeks to Decades 科技报告
来源:World Meteorological Organization (WMO). 出版年: 2011
作者:  Ben Kirtman;  David Anderson;  Gilbert Brunet;  In-Sik Kang;  Adam Scaife;  Doug Smith;  World Meteorological Organization
收藏  |  浏览/下载:22/0  |  提交时间:2019/04/05
Observations  Weather  Weather forecasting  Research  - International