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Molecular architecture of lineage allocation and tissue organization in early mouse embryo (vol 572, 528, 2019) 期刊论文
NATURE, 2020, 577 (7791) : E6-E6
作者:  Peng, Guangdun;  Suo, Shengbao;  Cui, Guizhong;  Yu, Fang;  Wang, Ran;  Chen, Jun;  Chen, Shirui;  Liu, Zhiwen;  Chen, Guoyu;  Qian, Yun;  Tam, Patrick P. L.;  Han, Jing-Dong J.;  Jing, Naihe
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03
Millennial-scale hydroclimate control of tropical soil carbon storage 期刊论文
NATURE, 2020, 581 (7806) : 63-+
作者:  Lam, Tommy Tsan-Yuk;  Jia, Na;  Zhang, Ya-Wei;  Shum, Marcus Ho-Hin;  Jiang, Jia-Fu;  Zhu, Hua-Chen;  Tong, Yi-Gang;  Shi, Yong-Xia;  Ni, Xue-Bing;  Liao, Yun-Shi;  Li, Wen-Juan;  Jiang, Bao-Gui;  Wei, Wei;  Yuan, Ting-Ting;  Zheng, Kui;  Cui, Xiao-Ming;  Li, Jie;  Pei, Guang-Qian
收藏  |  浏览/下载:61/0  |  提交时间:2020/05/13

Over the past 18,000 years, the residence time and amount of soil carbon stored in the Ganges-Brahmaputra basin have been controlled by the intensity of Indian Summer Monsoon rainfall, with greater carbon destabilization during wetter, warmer conditions.


The storage of organic carbon in the terrestrial biosphere directly affects atmospheric concentrations of carbon dioxide over a wide range of timescales. Within the terrestrial biosphere, the magnitude of carbon storage can vary in response to environmental perturbations such as changing temperature or hydroclimate(1), potentially generating feedback on the atmospheric inventory of carbon dioxide. Although temperature controls the storage of soil organic carbon at mid and high latitudes(2,3), hydroclimate may be the dominant driver of soil carbon persistence in the tropics(4,5)  however, the sensitivity of tropical soil carbon turnover to large-scale hydroclimate variability remains poorly understood. Here we show that changes in Indian Summer Monsoon rainfall have controlled the residence time of soil carbon in the Ganges-Brahmaputra basin over the past 18,000 years. Comparison of radiocarbon ages of bulk organic carbon and terrestrial higher-plant biomarkers with co-located palaeohydrological records(6) reveals a negative relationship between monsoon rainfall and soil organic carbon stocks on a millennial timescale. Across the deglaciation period, a depletion of basin-wide soil carbon stocks was triggered by increasing rainfall and associated enhanced soil respiration rates. Our results suggest that future hydroclimate changes in tropical regions are likely to accelerate soil carbon destabilization, further increasing atmospheric carbon dioxide concentrations.


  
Mechanism of adrenergic Ca(V)1.2 stimulation revealed by proximity proteomics 期刊论文
NATURE, 2020, 577 (7792) : 695-+
作者:  Peng, Guangdun;  Suo, Shengbao;  Cui, Guizhong;  Yu, Fang;  Wang, Ran;  Chen, Jun;  Chen, Shirui;  Liu, Zhiwen;  Chen, Guoyu;  Qian, Yun;  Tam, Patrick P. L.;  Han, Jing-Dong J.;  Jing, Naihe
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/03

An in vivo approach to identify proteins whose enrichment near cardiac Ca(V)1.2 channels changes upon beta-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca2+ current.


Increased cardiac contractility during the fight-or-flight response is caused by beta-adrenergic augmentation of Ca(V)1.2 voltage-gated calcium channels(1-4). However, this augmentation persists in transgenic murine hearts expressing mutant Ca(V)1.2 alpha(1C) and beta subunits that can no longer be phosphorylated by protein kinase A-an essential downstream mediator of beta-adrenergic signalling-suggesting that non-channel factors are also required. Here we identify the mechanism by which beta-adrenergic agonists stimulate voltage-gated calcium channels. We express alpha(1C) or beta(2B) subunits conjugated to ascorbate peroxidase(5) in mouse hearts, and use multiplexed quantitative proteomics(6,7) to track hundreds of proteins in the proximity of Ca(V)1.2. We observe that the calcium-channel inhibitor Rad(8,9), a monomeric G protein, is enriched in the Ca(V)1.2 microenvironment but is depleted during beta-adrenergic stimulation. Phosphorylation by protein kinase A of specific serine residues on Rad decreases its affinity for beta subunits and relieves constitutive inhibition of Ca(V)1.2, observed as an increase in channel open probability. Expression of Rad or its homologue Rem in HEK293T cells also imparts stimulation of Ca(V)1.3 and Ca(V)2.2 by protein kinase A, revealing an evolutionarily conserved mechanism that confers adrenergic modulation upon voltage-gated calcium channels.


  
Long-Term Exposure to Ambient Fine Particulate Matter (PM2.5) and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2019, 127 (12)
作者:  Guo, Cui;  Hoek, Gerard;  Chang, Ly-yun;  Bo, Yacong;  Lin, Changqing;  Huang, Bo;  Chan, Ta-chien;  Tam, Tony;  Lau, Alexis K. H.;  Lao, Xiang Qian
收藏  |  浏览/下载:31/0  |  提交时间:2020/02/17
Fatigue-resistant high-performance elastocaloric materials made by additive manufacturing 期刊论文
SCIENCE, 2019, 366 (6469) : 1116-+
作者:  Hou, Huilong;  Simsek, Emrah;  Ma, Tao;  Johnson, Nathan S.;  Qian, Suxin;  Cisse, Cheikh;  Stasak, Drew;  Al Hasan, Naila;  Zhou, Lin;  Hwang, Yunho;  Radermacher, Reinhard;  Levitas, Valery I.;  Kramer, Matthew J.;  Zaeem, Mohsen Asle;  Stebner, Aaron P.;  Ott, Ryan T.;  Cui, Jun;  Takeuchi, Ichiro
收藏  |  浏览/下载:38/0  |  提交时间:2020/02/17
Long-Term Exposure to Fine Particulate Matter, Blood Pressure, and Incident Hypertension in Taiwanese Adults 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2018, 126 (1)
作者:  Zhang, Zilong;  Guo, Cui;  Lau, Alexis K. H.;  Chan, Ta-Chien;  ChiehChuang, Yuan;  Lin, Changqing;  KaiJiang, Wun;  Yeoh, Eng-kiong;  Tam, Tony;  Woo, Kam S.;  Yan, Bryan P.;  Chang, Ly-Yun;  Wong, Martin C. S.;  Lao, Xiang Qian
收藏  |  浏览/下载:31/0  |  提交时间:2019/04/09
An updated emission inventory of vehicular VOCs and IVOCs in China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (20)
作者:  Liu, Huan;  Man, Hanyang;  Cui, Hongyang;  Wang, Yanjun;  Deng, Fanyuan;  Wang, Yue;  Yang, Xiaofan;  Xiao, Qian;  Zhang, Qiang;  Ding, Yan;  He, Kebin
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Evaluation of SMAP, SMOS, and AMSR2 soil moisture retrievals against observations from two networks on the Tibetan Plateau 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2017, 122 (11)
作者:  Chen, Yingying;  Yang, Kun;  Qin, Jun;  Cui, Qian;  Lu, Hui;  La, Zhu;  Han, Menglei;  Tang, Wenjun
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09
satellite soil moisture products  soil moisture networks  Tibetan Plateau  evaluation  
基于SMAP和Sentinel-1数据的被动微波土壤水分降尺度研究 项目
项目编号:41601401; 经费:190000(CNY); 起止日期:2017 / dc_date_end
项目负责人:  崔倩
收藏  |  浏览/下载:10/0  |  提交时间:2019/04/11