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Body size and digestive system shape resource selection by ungulates: A cross-taxa test of the forage maturation hypothesis 期刊论文
Ecology Letters, 2021
作者:  Saeideh Esmaeili;  Brett R. Jesmer;  Shannon E. Albeke;  Ellen O. Aikens;  Kathryn A. Schoenecker;  Sarah R. B. King;  Briana Abrahms;  Bayarbaatar Buuveibaatar;  Jeffrey L. Beck;  Randall B. Boone;  Francesca Cagnacci;  Simon Chamaillé;  -Jammes;  Buyanaa Chimeddorj;  Paul C. Cross;  Nandintsetseg Dejid;  Jagdag Enkhbyar;  Ilya R. Fischhoff;  Adam T. Ford;  Kate Jenks;  Mahmoud-Reza Hemami;  Jacob D. Hennig;  Takehiko Y. Ito;  Petra Kaczensky;  Matthew J. Kauffman;  John D. C. Linnell;  Badamjav Lkhagvasuren;  John F. McEvoy;  Joerg Melzheimer;  Jerod A. Merkle;  Thomas Mueller;  Jeff Muntifering;  Atle Mysterud;  Kirk A. Olson;  Manuela Panzacchi;  John C. Payne;  Luca Pedrotti;  Geir R. Rauset;  Daniel I. Rubenstein;  Hall Sawyer;  John. D. Scasta;  Johannes Signer;  Melissa Songer;  Jared A. Stabach;  Seth Stapleton;  Olav Strand;  Siva R. Sundaresan;  Dorj Usukhjargal;  Ganbold Uuganbayar;  John M. Fryxell;  Jacob R. Goheen
收藏  |  浏览/下载:50/0  |  提交时间:2021/08/10
Epigenetic inheritance of DNA methylation changes in fish living in hydrogen sulfide–rich springs 期刊论文
Proceedings of the National Academy of Sciences, 2021
作者:  Joanna L. Kelley;  Michael Tobler;  Daniel Beck;  Ingrid Sadler-Riggleman;  Corey R. Quackenbush;  Lenin Arias Rodriguez;  Michael K. Skinner
收藏  |  浏览/下载:27/0  |  提交时间:2021/06/24
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications 期刊论文
Science, 2021
作者:  Vignesh Kasinath;  Curtis Beck;  Paul Sauer;  Simon Poepsel;  Jennifer Kosmatka;  Marco Faini;  Daniel Toso;  Ruedi Aebersold;  Eva Nogales
收藏  |  浏览/下载:15/0  |  提交时间:2021/01/28
The Deformational Journey of the Nazca Slab From Seismic Anisotropy 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (11)
作者:  Agrawal, Shubham;  Eakin, Caroline M.;  Portner, Daniel E.;  Rodriguez, Emily E.;  Beck, Susan L.
收藏  |  浏览/下载:18/0  |  提交时间:2020/05/13
Nazca slab  seismic anisotropy  source side splitting  slab anisotropy  slab deformation  
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease 期刊论文
NATURE, 2020, 577 (7788) : 103-+
作者:  Lalaoui, Najoua;  Boyden, Steven E.;  Oda, Hirotsugu;  Wood, Geryl M.;  Stone, Deborah L.;  Chau, Diep;  Liu, Lin;  Stoffels, Monique;  Kratina, Tobias;  Lawlor, Kate E.;  Zaal, Kristien J. M.;  Hoffmann, Patrycja M.;  Etemadi, Nima;  Shield-Artin, Kristy;  Biben, Christine;  Tsai, Wanxia Li;  Blake, Mary D.;  Kuehn, Hye Sun;  Yang, Dan;  Anderton, Holly;  Silke, Natasha;  Wachsmuth, Laurens;  Zheng, Lixin;  Moura, Natalia Sampaio;  Beck, David B.;  Gutierrez-Cruz, Gustavo;  Ombrello, Amanda K.;  Pinto-Patarroyo, Gineth P.;  Kueh, Andrew J.;  Herold, Marco J.;  Hall, Cathrine;  Wang, Hongying;  Chae, Jae Jin;  Dmitrieva, Natalia I.;  McKenzie, Mark;  Light, Amanda;  Barham, Beverly K.;  Jones, Anne;  Romeo, Tina M.;  Zhou, Qing;  Aksentijevich, Ivona;  Mullikin, James C.;  Gross, Andrew J.;  Shum, Anthony K.;  Hawkins, Edwin D.;  Masters, Seth L.;  Lenardo, Michael J.;  Boehm, Manfred;  Rosenzweig, Sergio D.;  Pasparakis, Manolis;  Voss, Anne K.;  Gadina, Massimo;  Kastner, Daniel L.;  Silke, John
收藏  |  浏览/下载:74/0  |  提交时间:2020/07/03

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term '  cleavage-resistant RIPK1-induced autoinflammatory syndrome'  . To define the mechanism for this disease, we generated a cleavage-resistant Ripk1(D325A) mutant mouse strain. Whereas Ripk1(-/-) mice died postnatally from systemic inflammation, Ripk1(D325A/D325A) mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1(D325A/D325A) and Ripk1(D325A/+) cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.


  
Financing coastal resilience by combining nature-based risk reduction with insurance 期刊论文
ECOLOGICAL ECONOMICS, 2020, 169
作者:  Reguero, Borja G.;  Beck, Michael W.;  Schmid, David;  Stadtmueller, Daniel;  Raepple, Justus;  Schiissele, Stefan;  Pfliegner, Kerstin
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/02
Resilience insurance  
Plasmepsins IX and X are essential and draggable mediators of malaria parasite egress and invasion 期刊论文
SCIENCE, 2017, 358 (6362) : 518-+
作者:  Nasamu, Armiyaw S.;  Glushakova, Svetlana;  Russo, Ilaria;  Vaupel, Barbara;  Oksman, Anna;  Kim, Arthur S.;  Fremont, Daved H.;  Tolia, Niraj;  Beck, Josh R.;  Meyers, Marvin J.;  Niles, Jacquin C.;  Zimmerberg, Joshua;  Goldberg, Daniel E.
收藏  |  浏览/下载:26/0  |  提交时间:2019/11/27
Mantle flow through a tear in the Nazca slab inferred from shear wave splitting 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (13)
作者:  Lynner, Colton;  Anderson, Megan L.;  Portner, Daniel E.;  Beck, Susan L.;  Gilbert, Hersh
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
The nature of subslab slow velocity anomalies beneath South America 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (10)
作者:  Portner, Daniel Evan;  Beck, Susan;  Zandt, George;  Scire, Alissa
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
tomography  hot spots  subduction  South America