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A Late Cretaceous true polar wander oscillation 期刊论文
Nature Communications, 2021
作者:  Ross N. Mitchell;  Christopher J. Thissen;  David A. D. Evans;  Sarah P. Slotznick;  Rodolfo Coccioni;  Toshitsugu Yamazaki;  Joseph L. Kirschvink
收藏  |  浏览/下载:33/0  |  提交时间:2021/06/24
Stepwise pathogenic evolution of Mycobacterium abscessus 期刊论文
Science, 2021
作者:  Josephine M. Bryant;  Karen P. Brown;  Sophie Burbaud;  Isobel Everall;  Juan M. Belardinelli;  Daniela Rodriguez-Rincon;  Dorothy M. Grogono;  Chelsea M. Peterson;  Deepshikha Verma;  Ieuan E. Evans;  Christopher Ruis;  Aaron Weimann;  Divya Arora;  Sony Malhotra;  Bridget Bannerman;  Charlotte Passemar;  Kerra Templeton;  Gordon MacGregor;  Kasim Jiwa;  Andrew J. Fisher;  Tom L. Blundell;  Diane J. Ordway;  Mary Jackson;  Julian Parkhill;  R. Andres Floto
收藏  |  浏览/下载:36/0  |  提交时间:2021/05/07
Publisher Correction: Current and future global climate impacts resulting from COVID-19 期刊论文
Nature, 2020
作者:  Piers M. Forster;  Harriet I. Forster;  Mat J. Evans;  Matthew J. Gidden;  Chris D. Jones;  Christoph A. Keller;  Robin D. Lamboll;  Corinne Le Qué;  ;  Joeri Rogelj;  Deborah Rosen;  Carl-Friedrich Schleussner;  Thomas B. Richardson;  Christopher J. Smith;  Steven T. Turnock
收藏  |  浏览/下载:30/0  |  提交时间:2020/08/18
Current and future global climate impacts resulting from COVID-19 期刊论文
Nature, 2020
作者:  Piers M. Forster;  Harriet I. Forster;  Mat J. Evans;  Matthew J. Gidden;  Chris D. Jones;  Christoph A. Keller;  Robin D. Lamboll;  Corinne Le Qué;  ;  Joeri Rogelj;  Deborah Rosen;  Carl-Friedrich Schleussner;  Thomas B. Richardson;  Christopher J. Smith;  Steven T. Turnock
收藏  |  浏览/下载:40/0  |  提交时间:2020/08/18
Current and future global climate impacts resulting from COVID-19 科技报告
来源:Climate Analytics. 出版年: 2020
作者:  Piers M. Forster;  Harriet I. Forster;  Mat J. Evans;  Matthew J. Gidden;  Chris D. Jones;  Christoph A. Keller;  Robin D. Lamboll;  Corinne Le Quéré;  Joeri Rogelj;  Deborah Rosen;  Carl-Friedrich Schleussner;  Thomas B. Richardson;  Christopher J. Smith;  Steven T. Turnock
收藏  |  浏览/下载:43/0  |  提交时间:2020/08/18
Continental‐scale tree‐ring‐based projection of Douglas‐fir growth: Testing the limits of space‐for‐time substitution 期刊论文
Global Change Biology, 2020
作者:  Stefan Klesse;  Robert Justin DeRose;  Flurin Babst;  Bryan A. Black;  Leander D. L. Anderegg;  Jodi Axelson;  Ailene Ettinger;  Hardy Griesbauer;  Christopher H. Guiterman;  Grant Harley;  Jill E. Harvey;  Yueh‐;  Hsin Lo;  Ann M. Lynch;  Christopher O'Connor;  Christina Restaino;  Dave Sauchyn;  John D. Shaw;  Dan J. Smith;  Lisa Wood;  Jose Villanueva‐;  ;  az;  Margaret E. K. Evans
收藏  |  浏览/下载:21/0  |  提交时间:2020/07/06
Structures of human pannexin 1 reveal ion pathways and mechanism of gating 期刊论文
NATURE, 2020
作者:  Krause, David W.;  Hoffmann, Simone;  Hu, Yaoming;  Wible, John R.;  Rougier, Guillermo W.;  Kirk, E. Christopher;  Groenke, Joseph R.;  Rogers, Raymond R.;  Rossie, James B.;  Schultz, Julia A.;  Evans, Alistair R.;  von Koenigswald, Wighart;  Rahantarisoa, Lydia J.
收藏  |  浏览/下载:26/0  |  提交时间:2020/07/03

Cryo-electron microscopy structures of the ATP-permeable channel pannexin 1 reveal a gating mechanism involving multiple distinct ion-conducting pathways.


Pannexin 1 (PANX1) is an ATP-permeable channel with critical roles in a variety of physiological functions such as blood pressure regulation(1), apoptotic cell clearance(2) and human oocyte development(3). Here we present several structures of human PANX1 in a heptameric assembly at resolutions of up to 2.8 angstrom, including an apo state, a caspase-7-cleaved state and a carbenoxolone-bound state. We reveal a gating mechanism that involves two ion-conducting pathways. Under normal cellular conditions, the intracellular entry of the wide main pore is physically plugged by the C-terminal tail. Small anions are conducted through narrow tunnels in the intracellular domain. These tunnels connect to the main pore and are gated by a long linker between the N-terminal helix and the first transmembrane helix. During apoptosis, the C-terminal tail is cleaved by caspase, allowing the release of ATP through the main pore. We identified a carbenoxolone-binding site embraced by W74 in the extracellular entrance and a role for carbenoxolone as a channel blocker. We identified a gap-junction-like structure using a glycosylation-deficient mutant, N255A. Our studies provide a solid foundation for understanding the molecular mechanisms underlying the channel gating and inhibition of PANX1 and related large-pore channels.


  
Global inorganic nitrate production mechanisms: comparison of a global model with nitrate isotope observations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 3859-3877
作者:  Alexander, Becky;  Sherwen, Tomas;  Holmes, Christopher D.;  Fisher, Jenny A.;  Chen, Qianjie;  Evans, Mat J.;  Kasibhatla, Prasad
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/02
Detrital shocked zircon provides first radiometric age constraint (< 1472 Ma) for the Santa Fe impact structure, New Mexico, USA 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2019, 131: 845-863
作者:  Montalvo, Pedro E.;  Cavosie, Aaron J.;  Kirkland, Christopher L.;  Evans, Noreen J.;  Mcdonald, Bradley J.;  Talavera, Cristina;  Erickson, Timmons M.;  Lugo-Centeno, Cristina
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/26
Response to Comment on "An excess of massive stars in the local 30 Doradus starburst" 期刊论文
SCIENCE, 2018, 361 (6400)
作者:  Schneider, Fabian R. N.;  Sana, Hugues;  Evans, Christopher J.;  Bestenlehner, Joachim M.;  Castro, Norberto;  Fossati, Luca;  Graefener, Goetz;  Langer, Norbert;  Ramirez-Agudelo, Oscar H.;  Sabin-Sanjulian, Carolina;  Simon-Diaz, Sergio;  Tramper, Frank;  Crowther, Paul A.;  de Koter, Alexander;  de Mink, Selma E.;  Dufton, Philip L.;  Garcia, Miriam;  Gieles, Mark;  Henault-Brunet, Vincent;  Herrero, Artemio;  Izzard, Robert G.;  Kalari, Venu;  Lennon, Danny J.;  Maiz Apellaniz, Jesus;  Markova, Nevy;  Najarro, Francisco;  Podsiadlowski, Philipp;  Puls, Joachim;  Taylor, William D.;  van Loon, Jacco Th.;  Vink, Jorick S.;  Norman, Colin
收藏  |  浏览/下载:29/0  |  提交时间:2019/11/27