中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共13条，第1-10条 帮助

已选(0)清除 条数/页：   排序方式：
Association of Sulfur, Transition Metals, and the Oxidative Potential of Outdoor PM2.5 with Acute Cardiovascular Events: A Case-Crossover Study of Canadian Adults 期刊论文
Environmental Health Perspectives, 2021
作者:  Scott Weichenthal;  Eric Lavigne;  Alison Traub;  Dana Umbrio;  Hongyu You;  Krystal Pollitt;  Tim Shin;  Ryan Kulka;  Dave M. Stieb;  Jill Korsiak;  Barry Jessiman;  Jeff R. Brook;  Marianne Hatzopoulou;  Greg Evans;  Richard T. Burnett
收藏  |  浏览/下载：27/0  |  提交时间：2021/10/22
Approaching the motional ground state of a 10-kg object 期刊论文
Science, 2021
作者:  Chris Whittle;  Evan D. Hall;  Sheila Dwyer;  Nergis Mavalvala;  Vivishek Sudhir;  R. Abbott;  A. Ananyeva;  C. Austin;  L. Barsotti;  J. Betzwieser;  C. D. Blair;  A. F. Brooks;  D. D. Brown;  A. Buikema;  C. Cahillane;  J. C. Driggers;  A. Effler;  A. Fernandez-Galiana;  P. Fritschel;  V. V. Frolov;  T. Hardwick;  M. Kasprzack;  K. Kawabe;  N. Kijbunchoo;  J. S. Kissel;  G. L. Mansell;  F. Matichard;  L. McCuller;  T. McRae;  A. Mullavey;  A. Pele;  R. M. S. Schofield;  D. Sigg;  M. Tse;  G. Vajente;  D. C. Vander-Hyde;  Hang Yu;  Haocun Yu;  C. Adams;  R. X. Adhikari;  S. Appert;  K. Arai;  J. S. Areeda;  Y. Asali;  S. M. Aston;  A. M. Baer;  M. Ball;  S. W. Ballmer;  S. Banagiri;  D. Barker;  J. Bartlett;  B. K. Berger;  D. Bhattacharjee;  G. Billingsley;  S. Biscans;  R. M. Blair;  N. Bode;  P. Booker;  R. Bork;  A. Bramley;  K. C. Cannon;  X. Chen;  A. A. Ciobanu;  F. Clara;  C. M. Compton;  S. J. Cooper;  K. R. Corley;  S. T. Countryman;  P. B. Covas;  D. C. Coyne;  L. E. H. Datrier;  D. Davis;  C. Di Fronzo;  K. L. Dooley;  P. Dupej;  T. Etzel;  M. Evans;  T. M. Evans;  J. Feicht;  P. Fulda;  M. Fyffe;  J. A. Giaime;  K. D. Giardina;  P. Godwin;  E. Goetz;  S. Gras;  C. Gray;  R. Gray;  A. C. Green;  E. K. Gustafson;  R. Gustafson;  J. Hanks;  J. Hanson;  R. K. Hasskew;  M. C. Heintze;  A. F. Helmling-Cornell;  N. A. Holland;  J. D. Jones;  S. Kandhasamy;  S. Karki;  P. J. King;  Rahul Kumar;  M. Landry;  B. B. Lane;  B. Lantz;  M. Laxen;  Y. K. Lecoeuche;  J. Leviton;  J. Liu;  M. Lormand;  A. P. Lundgren;  R. Macas;  M. MacInnis;  D. M. Macleod;  S. Márka;  Z. Márka;  D. V. Martynov;  K. Mason;  T. J. Massinger;  R. McCarthy;  D. E. McClelland;  S. McCormick;  J. McIver;  G. Mendell;  K. Merfeld;  E. L. Merilh;  F. Meylahn;  T. Mistry;  R. Mittleman;  G. Moreno;  C. M. Mow-Lowry;  S. Mozzon;  T. J. N. Nelson;  P. Nguyen;  L. K. Nuttall;  J. Oberling;  Richard J. Oram;  C. Osthelder;  D. J. Ottaway;  H. Overmier;  J. R. Palamos;  W. Parker;  E. Payne;  R. Penhorwood;  C. J. Perez;  M. Pirello;  H. Radkins;  K. E. Ramirez;  J. W. Richardson;  K. Riles;  N. A. Robertson;  J. G. Rollins;  C. L. Romel;  J. H. Romie;  M. P. Ross;  K. Ryan;  T. Sadecki;  E. J. Sanchez;  L. E. Sanchez;  T. R. Saravanan;  R. L. Savage;  D. Schaetz;  R. Schnabel;  E. Schwartz;  D. Sellers;  T. Shaffer;  B. J. J. Slagmolen;  J. R. Smith;  S. Soni;  B. Sorazu;  A. P. Spencer;  K. A. Strain;  L. Sun;  M. J. Szczepańczyk;  M. Thomas;  P. Thomas;  K. A. Thorne;  K. Toland;  C. I. Torrie;  G. Traylor;  A. L. Urban;  G. Valdes;  P. J. Veitch;  K. Venkateswara;  G. Venugopalan;  A. D. Viets;  T. Vo;  C. Vorvick;  M. Wade;  R. L. Ward;  J. Warner;  B. Weaver;  R. Weiss;  B. Willke;  C. C. Wipf;  L. Xiao;  H. Yamamoto;  L. Zhang;  M. E. Zucker;  J. Zweizig
收藏  |  浏览/下载：52/0  |  提交时间：2021/06/24
Residence time determines invasiveness and performance of garlic mustard (Alliaria petiolata) in North America 期刊论文
Ecology Letters, 2020
作者:  Bernd Blossey;  Victoria Nuzzo;  Andrea Dá;  valos;  Mark Mayer;  Richard Dunbar;  Douglas A. Landis;  Jeffrey A. Evans;  Bill Minter
收藏  |  浏览/下载：16/0  |  提交时间：2020/12/22
Changes in the Arctic Ocean Carbon Cycle With Diminishing Ice Cover 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  DeGrandpre, Michael;  Evans, Wiley;  Timmermans, Mary-Louise;  Krishfield, Richard;  Williams, Bill;  Steele, Michael
收藏  |  浏览/下载：27/0  |  提交时间：2020/05/25
Arctic Ocean  ice concentration  seawater CO2  interannual variability  Canada Basin  shipboard CO2 measurements  
Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy 期刊论文
NATURE, 2020, 578 (7794) : 273-+
作者:  Senior, Andrew W.;  Evans, Richard;  Jumper, John;  Kirkpatrick, James;  Sifre, Laurent;  Green, Tim;  Qin, Chongli;  Zidek, Augustin;  Nelson, Alexander W. R.;  Bridgland, Alex;  Penedones, Hugo;  Petersen, Stig;  Simonyan, Karen;  Crossan, Steve;  Kohli, Pushmeet;  Jones, David T.;  Silver, David;  Kavukcuoglu, Koray;  Hassabis, Demis
收藏  |  浏览/下载：59/0  |  提交时间：2020/07/03

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of alpha-synuclein, including Parkinson'  s disease, dementia with Lewy bodies and multiple system atrophy(1). Clinically, it is challenging to differentiate Parkinson'  s disease and multiple system atrophy, especially at the early stages of disease(2). Aggregates of alpha-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of alpha-synuclein that can self-propagate and spread from cell to cell(3-6). Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect alpha-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity(7,8). Here we show that the alpha-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson'  s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%. We used a combination of biochemical, biophysical and biological methods to analyse the product of alpha-synuclein-PMCA, and found that the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid could be used to readily distinguish between Parkinson'  s disease and multiple system atrophy. We also found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar to those of aggregates that were amplified from the brain. These findings suggest that alpha-synuclein aggregates that are associated with Parkinson'  s disease and multiple system atrophy correspond to different conformational strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA. Our results may help to improve our understanding of the mechanism of alpha-synuclein misfolding and the structures of the aggregates that are implicated in different synucleinopathies, and may also enable the development of a biochemical assay to discriminate between Parkinson'  s disease and multiple system atrophy.


Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson'  s disease and patients with multiple system atrophy on the basis of the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid.


  
Northern Hemisphere Blocking in similar to 25-km-Resolution E3SM v0.3 Atmosphere-Land Simulations 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (5) : 2465-2482
作者:  Jiang, Tianyu;  Evans, Katherine;  Branstetter, Marcia;  Caldwell, Peter;  Neale, Richard;  Rasch, Philip J.;  Tang, Qi;  Xie, Shaocheng
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/26
Solvatochromic covalent organic frameworks 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Ascherl, Laura;  Evans, Emrys W.;  Hennemann, Matthias;  Di Nuzzo, Daniele;  Hufnagel, Alexander G.;  Beetz, Michael;  Friend, Richard H.;  Clark, Timothy;  Bein, Thomas;  Auras, Florian
收藏  |  浏览/下载：14/0  |  提交时间：2019/11/27
Trough geometry was a greater influence than climate-ocean forcing in regulating retreat of the marine-based Irish-Sea Ice Stream 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2018, 130: 1981-1999
作者:  Small, David;  Smedley, Rachel K.;  Chiverrell, Richard C.;  Scourse, James D.;  Cofaigh, Colm O.;  Duller, Geoff A. T.;  McCarron, Stephen;  Burke, Matthew J.;  Evans, David J. A.;  Fabel, Derek;  Gheorghiu, Delia M.;  Thomas, Geoff S. P.;  Xu, Sheng;  Clark, Chris D.
收藏  |  浏览/下载：37/0  |  提交时间：2019/04/09
Seeded growth of single-crystal two-dimensional covalent organic frameworks 期刊论文
SCIENCE, 2018, 361 (6397) : 53-+
作者:  Evans, Austin M.;  Parent, Lucas R.;  Flanders, Nathan C.;  Bisbey, Ryan P.;  Vitaku, Edon;  Kirschner, Matthew S.;  Schaller, Richard D.;  Chen, Lin X.;  Gianneschi, Nathan C.;  Dichtel, William R.
收藏  |  浏览/下载：16/0  |  提交时间：2019/11/27
Temporally delineated sources of major chemical species in high Arctic snow 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (5) : 3485-3503
作者:  Macdonald, Katrina M.;  Sharma, Sangeeta;  Toom, Desiree;  Chivulescu, Alina;  Platt, Andrew;  Elsasser, Mike;  Huang, Lin;  Leaitch, Richard;  Chellman, Nathan;  McConnell, Joseph R.;  Bozem, Heiko;  Kunkel, Daniel;  Lei, Ying Duan;  Jeong, Cheol-Heon;  Abbatt, Jonathan P. D.;  Evans, Greg J.
收藏  |  浏览/下载：17/0  |  提交时间：2019/04/09