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Demographic composition, not demographic diversity, predicts biomass and turnover across temperate and tropical forests 期刊论文
Global Change Biology, 2022
作者:  Jessica F. Needham;  Daniel J. Johnson;  Kristina J. Anderson-Teixeira;  Norman Bourg;  Sarayudh Bunyavejchewin;  Nathalie Butt;  Min Cao;  Dairon Cá;  rdenas;  Chia-Hao Chang-Yang;  Yu-Yun Chen;  George Chuyong;  Handanakere S. Dattaraja;  Stuart J. Davies;  Alvaro Duque;  Corneille E. N. Ewango;  Edwino S. Fernando;  Rosie Fisher;  Christine D. Fletcher;  Robin Foster;  Zhanqing Hao;  Terese Hart;  Chang-Fu Hsieh;  Stephen P. Hubbell;  Akira Itoh;  David Kenfack;  Charles D. Koven;  Andrew J. Larson;  James A. Lutz;  William McShea;  Jean-Remy Makana;  Yadvinder Malhi;  Toby Marthews;  Mohizah Bt. Mohamad;  Michael D. Morecroft;  Natalia Norden;  Geoffrey Parker;  Ankur Shringi;  Raman Sukumar;  Hebbalalu S. Suresh;  I-Fang Sun;  Sylvester Tan;  Duncan W. Thomas;  Jill Thompson;  Maria Uriarte;  Renato Valencia;  Tze Leong Yao;  Sandra L. Yap;  Zuoqiang Yuan;  Hu Yuehua;  Jess K. Zimmerman;  Daniel Zuleta;  Sean M. McMahon
收藏  |  浏览/下载:52/0  |  提交时间:2022/02/23
Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early life allergic asthma 期刊论文
Proceedings of the National Academy of Sciences, 2021
作者:  Mengjing Wang;  Qianqian Li;  Meifang Hou;  Louisa L. Y. Chan;  Meng Liu;  Soo Kai Ter;  Ting Dong;  Yun Xia;  Sanjay H. Chotirmall;  Mingliang Fang
收藏  |  浏览/下载:40/0  |  提交时间:2021/06/15
Measurement report: Amino acids in fine and coarse atmospheric aerosol: concentrations, compositions, sources and possible bacterial degradation state 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Ren-guo Zhu, Hua-Yun Xiao, Li Luo, Hongwei Xiao, Zequn Wen, Yuwen Zhu, Xiaozheng Fang, Yuanyuan Pan, and Zhenping Chen
收藏  |  浏览/下载:41/0  |  提交时间:2020/08/09
Molecular architecture of lineage allocation and tissue organization in early mouse embryo (vol 572, 528, 2019) 期刊论文
NATURE, 2020, 577 (7791) : E6-E6
作者:  Peng, Guangdun;  Suo, Shengbao;  Cui, Guizhong;  Yu, Fang;  Wang, Ran;  Chen, Jun;  Chen, Shirui;  Liu, Zhiwen;  Chen, Guoyu;  Qian, Yun;  Tam, Patrick P. L.;  Han, Jing-Dong J.;  Jing, Naihe
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03
Sources and Transformation Processes of Proteinaceous Matter and Free Amino Acids in PM2.5 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (5)
作者:  Zhu, Ren-guo;  Xiao, Hua-Yun;  Zhu, Yuwen;  Wen, Zequn;  Fang, Xiaozheng;  Pan, Yuanyuan
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/02
free amino acids  combined amino acids  PM2  5  nitrogen isotope  sources  transformation processes  
Nagaoka ferromagnetism observed in a quantum dot plaquette 期刊论文
NATURE, 2020, 579 (7800) : 528-533
作者:  Yu, Yong;  Ma, Fei;  Luo, Xi-Yu;  Jing, Bo;  Sun, Peng-Fei;  Fang, Ren-Zhou;  Yang, Chao-Wei;  Liu, Hui;  Zheng, Ming-Yang;  Xie, Xiu-Ping;  Zhang, Wei-Jun;  You, Li-Xing;  Wang, Zhen;  Chen, Teng-Yun;  Zhang, Qiang;  Bao, Xiao-Hui;  Pan, Jian-Wei
收藏  |  浏览/下载:53/0  |  提交时间:2020/07/03

A quantum dot device designed to host four electrons is used to demonstrate Nagaoka ferromagnetism-a model of itinerant magnetism that has so far been limited to theoretical investigation.


Engineered, highly controllable quantum systems are promising simulators of emergent physics beyond the simulation capabilities of classical computers(1). An important problem in many-body physics is itinerant magnetism, which originates purely from long-range interactions of free electrons and whose existence in real systems has been debated for decades(2,3). Here we use a quantum simulator consisting of a four-electron-site square plaquette of quantum dots(4) to demonstrate Nagaoka ferromagnetism(5). This form of itinerant magnetism has been rigorously studied theoretically(6-9) but has remained unattainable in experiments. We load the plaquette with three electrons and demonstrate the predicted emergence of spontaneous ferromagnetic correlations through pairwise measurements of spin. We find that the ferromagnetic ground state is remarkably robust to engineered disorder in the on-site potentials and we can induce a transition to the low-spin state by changing the plaquette topology to an open chain. This demonstration of Nagaoka ferromagnetism highlights that quantum simulators can be used to study physical phenomena that have not yet been observed in any experimental system. The work also constitutes an important step towards large-scale quantum dot simulators of correlated electron systems.


  
Epigenetic therapy inhibits metastases by disrupting premetastatic niches 期刊论文
NATURE, 2020, 579 (7798) : 284-+
作者:  Mehta, Vedanta;  Pang, Kar-Lai;  Rozbesky, Daniel;  Nather, Katrin;  Keen, Adam;  Lachowski, Dariusz;  Kong, Youxin;  Karia, Dimple;  Ameismeier, Michael;  Huang, Jianhua;  Fang, Yun;  del Rio Hernandez, Armando;  Reader, John S.;  Jones, E. Yvonne;  Tzima, Ellie
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Cancer recurrence after surgery remains an unresolved clinical problem(1-3). Myeloid cells derived from bone marrow contribute to the formation of the premetastatic microenvironment, which is required for disseminating tumour cells to engraft distant sites(4-6). There are currently no effective interventions that prevent the formation of the premetastatic microenvironment(6,7). Here we show that, after surgical removal of primary lung, breast and oesophageal cancers, low-dose adjuvant epigenetic therapy disrupts the premetastatic microenvironment and inhibits both the formation and growth of lung metastases through its selective effect on myeloid-derived suppressor cells (MDSCs). In mouse models of pulmonary metastases, MDSCs are key factors in the formation of the premetastatic microenvironment after resection of primary tumours. Adjuvant epigenetic therapy that uses low-dose DNA methyltransferase and histone deacetylase inhibitors, 5-azacytidine and entinostat, disrupts the premetastatic niche by inhibiting the trafficking of MDSCs through the downregulation of CCR2 and CXCR2, and by promoting MDSC differentiation into a more-interstitial macrophage-like phenotype. A decreased accumulation of MDSCs in the premetastatic lung produces longer periods of disease-free survival and increased overall survival, compared with chemotherapy. Our data demonstrate that, even after removal of the primary tumour, MDSCs contribute to the development of premetastatic niches and settlement of residual tumour cells. A combination of low-dose adjuvant epigenetic modifiers that disrupts this premetastatic microenvironment and inhibits metastases may permit an adjuvant approach to cancer therapy.


  
Mechanism of adrenergic Ca(V)1.2 stimulation revealed by proximity proteomics 期刊论文
NATURE, 2020, 577 (7792) : 695-+
作者:  Peng, Guangdun;  Suo, Shengbao;  Cui, Guizhong;  Yu, Fang;  Wang, Ran;  Chen, Jun;  Chen, Shirui;  Liu, Zhiwen;  Chen, Guoyu;  Qian, Yun;  Tam, Patrick P. L.;  Han, Jing-Dong J.;  Jing, Naihe
收藏  |  浏览/下载:42/0  |  提交时间:2020/07/03

An in vivo approach to identify proteins whose enrichment near cardiac Ca(V)1.2 channels changes upon beta-adrenergic stimulation finds the G protein Rad, which is phosphorylated by protein kinase A, thereby relieving channel inhibition by Rad and causing an increased Ca2+ current.


Increased cardiac contractility during the fight-or-flight response is caused by beta-adrenergic augmentation of Ca(V)1.2 voltage-gated calcium channels(1-4). However, this augmentation persists in transgenic murine hearts expressing mutant Ca(V)1.2 alpha(1C) and beta subunits that can no longer be phosphorylated by protein kinase A-an essential downstream mediator of beta-adrenergic signalling-suggesting that non-channel factors are also required. Here we identify the mechanism by which beta-adrenergic agonists stimulate voltage-gated calcium channels. We express alpha(1C) or beta(2B) subunits conjugated to ascorbate peroxidase(5) in mouse hearts, and use multiplexed quantitative proteomics(6,7) to track hundreds of proteins in the proximity of Ca(V)1.2. We observe that the calcium-channel inhibitor Rad(8,9), a monomeric G protein, is enriched in the Ca(V)1.2 microenvironment but is depleted during beta-adrenergic stimulation. Phosphorylation by protein kinase A of specific serine residues on Rad decreases its affinity for beta subunits and relieves constitutive inhibition of Ca(V)1.2, observed as an increase in channel open probability. Expression of Rad or its homologue Rem in HEK293T cells also imparts stimulation of Ca(V)1.3 and Ca(V)2.2 by protein kinase A, revealing an evolutionarily conserved mechanism that confers adrenergic modulation upon voltage-gated calcium channels.


  
East Asian Study of Tropospheric Aerosols and their Impact on Regional Clouds, Precipitation, and Climate (EAST-AIR(CPC)) 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (23) : 13026-13054
作者:  Li, Zhanqing;  Wang, Yuan;  Guo, Jianping;  Zhao, Chuanfeng;  Cribb, Maureen C.;  Dong, Xiquan;  Fan, Jiwen;  Gong, Daoyi;  Huang, Jianping;  Jiang, Mengjiao;  Jiang, Yiquan;  Lee, S. -S.;  Li, Huan;  Li, Jiming;  Liu, Jianjun;  Qian, Yun;  Rosenfeld, Daniel;  Shan, Siyu;  Sun, Yele;  Wang, Huijun;  Xin, Jinyuan;  Yan, Xin;  Yang, Xin;  Yang, Xiu-Qun;  Zhang, Fang;  Zheng, Youtong
收藏  |  浏览/下载:36/0  |  提交时间:2020/02/17
East Asian Study of Tropospheric Aerosols and their Impact on Regional Clouds, Precipitation, and Climate (EAST-AIR(CPC)) 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Li, Zhanqing;  Wang, Yuan;  Guo, Jianping;  Zhao, Chuanfeng;  Cribb, Maureen;  Dong, Xiquan;  Fan, Jiwen;  Gong, Daoyi;  Huang, Jianping;  Jiang, Mengjiao;  Jiang, Yiquan;  Lee, S-S;  Li, Huan;  Li, Jiming;  Liu, Jianjun;  Qian, Yun;  Rosenfeld, Daniel;  Shan, Siyu;  Sun, Yele;  Wang, Huijun;  Xin, Jinyuan;  Yan, Xin;  Yang, Xin;  Yang, Xiu-qun;  Zhang, Fang;  Zheng, Youtong
收藏  |  浏览/下载:45/0  |  提交时间:2020/02/17