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Horizontal gene transfer of Fhb7 from fungus underlies Fusarium head blight resistance in wheat 期刊论文
Science, 2020
作者:  Hongwei Wang;  Silong Sun;  Wenyang Ge;  Lanfei Zhao;  Bingqian Hou;  Kai Wang;  Zhongfan Lyu;  Liyang Chen;  Shoushen Xu;  Jun Guo;  Min Li;  Peisen Su;  Xuefeng Li;  Guiping Wang;  Cunyao Bo;  Xiaojian Fang;  Wenwen Zhuang;  Xinxin Cheng;  Jianwen Wu;  Luhao Dong;  Wuying Chen;  Wen Li;  Guilian Xiao;  Jinxiao Zhao;  Yongchao Hao;  Ying Xu;  Yu Gao;  Wenjing Liu;  Yanhe Liu;  Huayan Yin;  Jiazhu Li;  Xiang Li;  Yan Zhao;  Xiaoqian Wang;  Fei Ni;  Xin Ma;  Anfei Li;  Steven S. Xu;  Guihua Bai;  Eviatar Nevo;  Caixia Gao;  Herbert Ohm;  Lingrang Kong
收藏  |  浏览/下载:42/0  |  提交时间:2020/05/25
Extreme weather events recorded by daily to hourly resolution biogeochemical proxies of marine giant clam shells 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (13) : 7038-7043
作者:  Yan, Hong;  Liu, Chengcheng;  An, Zhisheng;  Yang, Wei;  Yang, Yuanjian;  Huang, Ping;  Qiu, Shican;  Zhou, Pengchao;  Zhao, Nanyu;  Fei, Haobai;  Ma, Xiaolin;  Shi, Ge;  Dodson, John;  Hao, Jialong;  Yu, Kefu;  Wei, Gangjian;  Yang, Yanan;  Jin, Zhangdong;  Zhou, Weijian
收藏  |  浏览/下载:36/0  |  提交时间:2020/05/13
Tridacna shell  daily growth bands  ultra-high resolution  biogeochemical proxies  weather-timescale extreme events  
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:75/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Assessment of ECMWF reanalysis data in complex terrain: Can the CERA-20C and ERA-Interim data sets replicate the variation in surface air temperatures over Sichuan, China? 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (15) : 5619-5634
作者:  Luo, Haolin;  Ge, Fei;  Yang, Kangquan;  Zhu, Shoupeng;  Peng, Ting;  Cai, Wenyue;  Liu, Xiaoran;  Tang, Weiwei
收藏  |  浏览/下载:25/0  |  提交时间:2020/02/17
ECMWF reanalysis  observational data analysis  Sichuan  surface air temperature  
Risks of precipitation extremes over Southeast Asia: does 1.5 degrees C or 2 degrees C global warming make a difference? 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (4)
作者:  Ge, Fei;  Zhu, Shoupeng;  Peng, Ting;  Zhao, Yong;  Sielmann, Frank;  Fraedrich, Klaus;  Zhi, Xiefei;  Liu, Xiaoran;  Tang, Weiwei;  Ji, Luying
收藏  |  浏览/下载:25/0  |  提交时间:2019/11/26
Paris agreement  CORDEX  regional climate change  extreme precipitation  Southeast Asia  
中南半岛夏季极端降水年际变化及其与海温异常的关系研究 项目
项目编号:41805056; 经费:265000(CNY); 起止日期:2019 / dc_date_end
项目负责人:  葛非
收藏  |  浏览/下载:24/0  |  提交时间:2019/11/27
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Liu, Feng;  Chen, Jianxia;  Wang, Peng;  Li, Haohao;  Zhou, Yilong;  Liu, Haipeng;  Liu, Zhonghua;  Zheng, Ruijuan;  Wang, Lin;  Yang, Hua;  Cui, Zhenling;  Wang, Fei;  Huang, Xiaochen;  Wang, Jie;  Sha, Wei;  Xiao, Heping;  Ge, Baoxue
收藏  |  浏览/下载:32/0  |  提交时间:2019/11/27
干旱荒漠区降水变化对植物间正相互作用的影响及其机制 项目
项目编号:41771551; 经费:600000(CNY); 起止日期:2018 / dc_date_end
项目负责人:  张格非
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
The link between Tibetan Plateau monsoon and Indian summer precipitation: a linear diagnostic perspective 期刊论文
CLIMATE DYNAMICS, 2017, 49
作者:  Ge, Fei;  Sielmann, Frank;  Zhu, Xiuhua;  Fraedrich, Klaus;  Zhi, Xiefei;  Peng, Ting;  Wang, Lei
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09
Tibetan Plateau summer monsoon (TPSM)  Tibetan Plateau thermal forcing  Asymmetric influence  Indian summer monsoon rainfall  
苯并[a]芘累积污染土壤的微生物多样性响应机理 项目
项目编号:41401278; 经费:260000(CNY); 起止日期:2015 / dc_date_end
项目负责人:  葛高飞
收藏  |  浏览/下载:18/0  |  提交时间:2019/04/11