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Photoelectron spectra of alkali metal–ammonia microjets: From blue electrolyte to bronze metal 期刊论文
Science, 2020
作者:  Tillmann Buttersack;  Philip E. Mason;  Ryan S. McMullen;  H. Christian Schewe;  Tomas Martinek;  Krystof Brezina;  Martin Crhan;  Axel Gomez;  Dennis Hein;  Garlef Wartner;  Robert Seidel;  Hebatallah Ali;  Stephan Thürmer;  Ondrej Marsalek;  Bernd Winter;  Stephen E. Bradforth;  Pavel Jungwirth
收藏  |  浏览/下载：24/0  |  提交时间：2020/06/09
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载：75/0  |  提交时间：2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Mars Science Laboratory Observations of the 2018/Mars Year 34 Global Dust Storm 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (1) : 71-79
作者:  Guzewich, Scott D.;  Lemmon, M.;  Smith, C. L.;  Martinez, G.;  de Vicente-Retortillo, A.;  Newman, C. E.;  Baker, M.;  Campbell, C.;  Cooper, B.;  Gomez-Elvira, J.;  Harri, A. -M.;  Hassler, D.;  Martin-Torres, F. J.;  McConnochie, T.;  Moores, J. E.;  Kahanpaa, H.;  Khayat, A.;  Richardson, M. I.;  Smith, M. D.;  Sullivan, R.;  de la Torre Juarez, M.;  Vasavada, A. R.;  Viudez-Moreiras, D.;  Zeitlin, C.;  Zorzano Mier, Maria-Paz
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Mars  Curiosity  Mars Science Laboratory  dust storm  
A global analysis of terrestrial plant litter dynamics in non-perennial waterways (vol 11, pg 497, 2018) 期刊论文
NATURE GEOSCIENCE, 2018, 11 (7) : 542-542
作者:  Datry, T.;  Foulquier, A.;  Corti, R.;  von Schiller, D.;  Tockner, K.;  Mendoza-Lera, C.;  Clement, J. C.;  Gessner, M. O.;  Moleon, M.;  Stubbington, R.;  Gucker, B.;  Albarino, R.;  Allen, D. C.;  Altermatt, F.;  Arce, M. I.;  Arnon, S.;  Banas, D.;  Banegas-Medina, A.;  Beller, E.;  Blanchette, M. L.;  Blanco-Libreros, J. F.;  Blessing, J. J.;  Boechat, I. G.;  Boersma, K. S.;  Bogan, M. T.;  Bonada, N.;  Bond, N. R.;  Barria, K. C. Brintrup;  Bruder, A.;  Burrows, R. M.;  Cancellario, T.;  Canhoto, C.;  Carlson, S. M.;  Cauvy-Fraunie, S.;  Cid, N.;  Danger, M.;  Terra, Bianca de Freitas;  De Girolamo, A. M.;  De La Barra, Evans;  Del Campo, R.;  Diaz-Villanueva, V. D.;  Dyer, F.;  Elosegi, A.;  Faye, E.;  Febria, C.;  Four, B.;  Gafny, S.;  Ghate, S. D.;  Gomez, R.;  Gomez-Gener, L.;  Graca, M. A. S.;  Guareschi, S.;  Hoppeler, F.;  Hwan, J. L.;  Jones, J. I.;  Kubheka, S.;  Laini, A.;  Langhans, S. D.;  Leigh, C.;  Little, C. J.;  Lorenz, S.;  Marshall, J. C.;  Martin, E.;  McIntosh, A. R.;  Meyer, E. I.;  Milisa, M.;  Mlambo, M. C.;  Morais, M.;  Moya, N.;  Negus, P. M.;  Niyogi, D. K.;  Papatheodoulou, A.;  Pardo, I.;  Paril, P.;  Pauls, S. U.;  Pesic, V.;  Polasek, M.;  Robinson, C. T.;  Rodriguez-Lozano, P.;  Rolls, R. J.;  Sanchez-Montoya, M. M.;  Savic, A.;  Shumilova, O.;  Sridhar, K. R.;  Steward, A. L.;  Storey, R.;  Taleb, A.;  Uzan, A.;  Vorste, Ross Vander;  Waltham, N. J.;  Woelfle-Erskine, C.;  Zak, D.;  Zarfl, C.;  Zoppini, A.
收藏  |  浏览/下载：35/0  |  提交时间：2019/04/09
A global analysis of terrestrial plant litter dynamics in non-perennial waterways 期刊论文
NATURE GEOSCIENCE, 2018, 11 (7) : 497-+
作者:  Datry, T.;  Foulquier, A.;  Corti, R.;  von Schiller, D.;  Tockner, K.;  Mendoza-Lera, C.;  Clement, J. C.;  Gessner, M. O.;  Moleon, M.;  Stubbington, R.;  Gucker, B.;  Albarino, R.;  Allen, D. C.;  Altermatt, F.;  Arce, M., I;  Arnon, S.;  Banas, D.;  Banegas-Medina, A.;  Beller, E.;  Blanchette, M. L.;  Blanco-Libreros, J. F.;  Blessing, J. J.;  Boechat, I. G.;  Boersma, K. S.;  Bogan, M. T.;  Bonada, N.;  Bond, N. R.;  Brintrup Barria, K. C.;  Bruder, A.;  Burrows, R. M.;  Cancellario, T.;  Canhoto, C.;  Carlson, S. M.;  Cauvy-Fraunie, S.;  Cid, N.;  Danger, M.;  Terra, Bianca de Freitas;  De Girolamo, A. M.;  de La Barra, Evans;  del Campo, R.;  Diaz-Villanueva, V. D.;  Dyer, F.;  Elosegi, A.;  Faye, E.;  Febria, C.;  Four, B.;  Gafny, S.;  Ghate, S. D.;  Gomez, R.;  Gomez-Gener, L.;  Graca, M. A. S.;  Guareschi, S.;  Hoppeler, F.;  Hwan, J. L.;  Jones, J., I;  Kubheka, S.;  Laini, A.;  Langhans, S. D.;  Leigh, C.;  Little, C. J.;  Lorenz, S.;  Marshall, J. C.;  Martin, E.;  McIntosh, A. R.;  Meyer, E., I;  Milisa, M.;  Mlambo, M. C.;  Morais, M.;  Moya, N.;  Negus, P. M.;  Niyogi, D. K.;  Papatheodoulou, A.;  Pardo, I;  Paril, P.;  Pauls, S. U.;  Pesic, V;  Polasek, M.;  Robinson, C. T.;  Rodriguez-Lozano, P.;  Rolls, R. J.;  Sanchez-Montoya, M. M.;  Savic, A.;  Shumilova, O.;  Sridhar, K. R.;  Steward, A. L.;  Storey, R.;  Taleb, A.;  Uzan, A.;  Vander Vorste, Ross;  Waltham, N. J.;  Woelfle-Erskine, C.;  Zak, D.;  Zarfl, C.;  Zoppini, A.
收藏  |  浏览/下载：33/0  |  提交时间：2019/04/09
Background levels of methane in Mars' atmosphere show strong seasonal variations 期刊论文
SCIENCE, 2018, 360 (6393) : 1093-+
作者:  Webster, Christopher R.;  Mahaffy, Paul R.;  Atreya, Sushil K.;  Moores, John E.;  Flesch, Gregory J.;  Malespin, Charles;  McKay, Christopher P.;  Martinez, German;  Smith, Christina L.;  Martin-Torres, Javier;  Gomez-Elvira, Javier;  Zorzano, Maria-Paz;  Wong, Michael H.;  Trainer, Melissa G.;  Steele, Andrew;  Archer, Doug, Jr.;  Sutter, Brad;  Coll, Patrice J.;  Freissinet, Caroline;  Meslin, Pierre-Yves;  Gough, Raina V.;  House, Christopher H.;  Pavlov, Alexander;  Eigenbrode, Jennifer L.;  Glavin, Daniel P.;  Pearson, John C.;  Keymeulen, Didier;  Christensen, Lance E.;  Schwenzer, Susanne P.;  Navarro-Gonzalez, Rafael;  Pla-Garcia, Jorge;  Rafkin, Scot C. R.;  Vicente-Retortillo, Alvaro;  Kahanpaa, Henrik;  Viudez-Moreiras, Daniel;  Smith, Michael D.;  Harri, Ari-Matti;  Genzer, Maria;  Hassler, Donald M.;  Lemmon, Mark;  Crisp, Joy;  Sander, Stanley P.;  Zurek, Richard W.;  Vasavada, Ashwin R.
收藏  |  浏览/下载：40/0  |  提交时间：2019/11/27
The SPARC water vapor assessment II: intercomparison of satellite and ground-based microwave measurements 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (23)
作者:  Nedoluha, Gerald E.;  Kiefer, Michael;  Lossow, Stefan;  Gomez, R. Michael;  Kampfer, Niklaus;  Lainer, Martin;  Forkman, Peter;  Christensen, Ole Martin;  Oh, Jung Jin;  Hartogh, Paul;  Anderson, John;  Bramstedt, Klaus;  Dinelli, Bianca M.;  Garcia-Comas, Maya;  Hervig, Mark;  Murtagh, Donal;  Raspollini, Piera;  Read, William G.;  Rosenlof, Karen;  Stiller, Gabriele P.;  Walker, Kaley A.
收藏  |  浏览/下载：24/0  |  提交时间：2019/04/09
Introducing landscape character assessment and the ecosystem service approach to India: A case study 期刊论文
LANDSCAPE AND URBAN PLANNING, 2017, 167
作者:  Bartlett, D.;  Gomez-Martin, E.;  Milliken, S.;  Parmer, D.
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Landscape  Ecosystem  Prosopis  Community  Participation  Gujarat  
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Joshi, Peter K.;  Pirastu, Nicola;  Kentistou, Katherine A.;  Fischer, Krista;  Hofer, Edith;  Schraut, Katharina E.;  Clark, David W.;  Nutile, Teresa;  Barnes, Catriona L. K.;  Timmers, Paul R. H. J.;  Shen, Xia;  Gandin, Ilaria;  McDaid, Aaron F.;  Hansen, Thomas Folkmann;  Gordon, Scott D.;  Giulianini, Franco;  Boutin, Thibaud S.;  Abdellaoui, Abdel;  Zhao, Wei;  Medina-Gomez, Carolina;  Bartz, Traci M.;  Trompet, Stella;  Lange, Leslie A.;  Raffield, Laura;  van der Spek, Ashley;  Galesloot, Tessel E.;  Proitsi, Petroula;  Yanek, Lisa R.;  Bielak, Lawrence F.;  Payton, Antony;  Murgia, Federico;  Concas, Maria Pina;  Biino, Ginevra;  Tajuddin, Salman M.;  Seppala, Ilkka;  Amin, Najaf;  Boerwinkle, Eric;  Borglum, Anders D.;  Campbell, Archie;  Demerath, Ellen W.;  Demuth, Ilja;  Faul, Jessica D.;  Ford, Ian;  Gialluisi, Alessandro;  Gogele, Martin;  Graff, MariaElisa;  Hingorani, Aroon;  Hottenga, Jouke-Jan;  Hougaard, David M.;  Hurme, Mikko A.;  Ikram, M. Arfan;  Jylha, Marja;  Kuh, Diana;  Ligthart, Lannie;  Lill, Christina M.;  Lindenberger, Ulman;  Lumley, Thomas;  Magi, Reedik;  Marques-Vidal, Pedro;  Medland, Sarah E.;  Milani, Lili;  Nagy, Reka;  Ollier, William E. R.;  Peyser, Patricia A.;  Pramstaller, Peter P.;  Ridker, Paul M.;  Rivadeneira, Fernando;  Ruggiero, Daniela;  Saba, Yasaman;  Schmidt, Reinhold;  Schmidt, Helena;  Slagboom, P. Eline;  Smith, Blair H.;  Smith, Jennifer A.;  Sotoodehnia, Nona;  Steinhagen-Thiessen, Elisabeth;  van Rooij, Frank J. A.;  Verbeek, Andre L.;  Vermeulen, Sita H.;  Vollenweider, Peter;  Wang, Yunpeng;  Werge, Thomas;  Whitfield, John B.;  Zonderman, Alan B.;  Lehtimaki, Terho;  Evans, Michele K.;  Pirastu, Mario;  Fuchsberger, Christian;  Bertram, Lars;  Pendleton, Neil;  Kardia, Sharon L. R.;  Ciullo, Marina;  Becker, Diane M.;  Wong, Andrew;  Psaty, Bruce M.;  van Duijn, Cornelia M.;  Wilson, James G.;  Jukema, J. Wouter;  Kiemeney, Lambertus;  Uitterlinden, Andre G.;  Franceschini, Nora;  North, Kari E.;  Weir, David R.;  Metspalu, Andres;  Boomsma, Dorret I.;  Hayward, Caroline;  Chasman, Daniel;  Martin, Nicholas G.;  Sattar, Naveed;  Campbell, Harry;  Esko, Tonu;  Kutalik, Zoltan;  Wilson, James F.
收藏  |  浏览/下载：38/0  |  提交时间：2019/11/27