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Haplotype-resolved diverse human genomes and integrated analysis of structural variation 期刊论文
Science, 2021
作者:  Peter Ebert;  Peter A. Audano;  Qihui Zhu;  Bernardo Rodriguez-Martin;  David Porubsky;  Marc Jan Bonder;  Arvis Sulovari;  Jana Ebler;  Weichen Zhou;  Rebecca Serra Mari;  Feyza Yilmaz;  Xuefang Zhao;  PingHsun Hsieh;  Joyce Lee;  Sushant Kumar;  Jiadong Lin;  Tobias Rausch;  Yu Chen;  Jingwen Ren;  Martin Santamarina;  Wolfram Höps;  Hufsah Ashraf;  Nelson T. Chuang;  Xiaofei Yang;  Katherine M. Munson;  Alexandra P. Lewis;  Susan Fairley;  Luke J. Tallon;  Wayne E. Clarke;  Anna O. Basile;  Marta Byrska-Bishop;  André Corvelo;  Uday S. Evani;  Tsung-Yu Lu;  Mark J. P. Chaisson;  Junjie Chen;  Chong Li;  Harrison Brand;  Aaron M. Wenger;  Maryam Ghareghani;  William T. Harvey;  Benjamin Raeder;  Patrick Hasenfeld;  Allison A. Regier;  Haley J. Abel;  Ira M. Hall;  Paul Flicek;  Oliver Stegle;  Mark B. Gerstein;  Jose M. C. Tubio;  Zepeng Mu;  Yang I. Li;  Xinghua Shi;  Alex R. Hastie;  Kai Ye;  Zechen Chong;  Ashley D. Sanders;  Michael C. Zody;  Michael E. Talkowski;  Ryan E. Mills;  Scott E. Devine;  Charles Lee;  Jan O. Korbel;  Tobias Marschall;  Evan E. Eichler
收藏  |  浏览/下载:64/0  |  提交时间:2021/04/06
Single-chain heteropolymers transport protons selectively and rapidly 期刊论文
NATURE, 2020, 577 (7789) : 216-+
作者:  Jiang, Tao;  Hall, Aaron;  Eres, Marco;  Hemmatian, Zahra;  Qiao, Baofu;  Zhou, Yun;  Ruan, Zhiyuan;  Couse, Andrew D.;  Heller, William T.;  Huang, Haiyan;  de la Cruz, Monica Olvera;  Rolandi, Marco;  Xu, Ting
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/03

Precise protein sequencing and folding are believed to generate the structure and chemical diversity of natural channels(1,2), both of which are essential to synthetically achieve proton transport performance comparable to that seen in natural systems. Geometrically defined channels have been fabricated using peptides, DNAs, carbon nanotubes, sequence-defined polymers and organic frameworks(3-13). However, none of these channels rivals the performance observed in their natural counterparts. Here we show that without forming an atomically structured channel, four-monomer-based random heteropolymers (RHPs)(14) can mimic membrane proteins and exhibit selective proton transport across lipid bilayers at a rate similar to those of natural proton channels. Statistical control over the monomer distribution in an RHP leads to segmental heterogeneity in hydrophobicity, which facilitates the insertion of single RHPs into the lipid bilayers. It also results in bilayer-spanning segments containing polar monomers that promote the formation of hydrogen-bonded chains(15,16) for proton transport. Our study demonstrates the importance of the adaptability that is enabled by statistical similarity among RHP chains and of the modularity provided by the chemical diversity of monomers, to achieve uniform behaviour in heterogeneous systems. Our results also validate statistical randomness as an unexplored approach to realize protein-like behaviour at the single-polymer-chain level in a predictable manner.


  
Iron-mediated organic matter decomposition in humid soils can counteract protection 期刊论文
Nature, 2020
作者:  Chunmei Chen;  Steven J. Hall;  Elizabeth Coward;  Aaron Thompson
收藏  |  浏览/下载:28/0  |  提交时间:2020/05/13
Streamflow response to forest management 期刊论文
NATURE, 2020, 578 (7794) : E12-E15
作者:  Jiang, Tao;  Hall, Aaron;  Eres, Marco;  Hemmatian, Zahra;  Qiao, Baofu;  Zhou, Yun;  Ruan, Zhiyuan;  Couse, Andrew D.;  Heller, William T.;  Huang, Haiyan;  de la Cruz, Monica Olvera;  Rolandi, Marco;  Xu, Ting
收藏  |  浏览/下载:17/0  |  提交时间:2020/05/13
Alternatives to genetic affinity as a context for within-species response to climate 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (10) : 787-+
作者:  Smith, Adam B.;  Beever, Erik A.;  Kessler, Aimee E.;  Johnston, Aaron N.;  Ray, Chris;  Epps, Clinton W.;  Lanier, Hayley C.;  Klinger, Rob C.;  Rodhouse, Thomas J.;  Varner, Johanna;  Perrine, John D.;  Seglund, Amy;  Hall, L. Embere;  Galbreath, Kurt;  MacGlover, Chris;  Billman, Peter;  Blatz, Gretchen;  Brewer, Jason;  Vardaro, Jessica Castillo;  Chalfoun, Anna D.;  Collins, Gail;  Craighead, April;  Curlis, Chris;  Daly, Christopher;  Doak, Daniel F.;  East, Mitch;  Edwards, Mark;  Erb, Liesl;  Ernest, Kristina A.;  Fauver, Brian;  Foresman, Kerry R.;  Goehring, Ken;  Hagar, Joan;  Hayes, Charles L.;  Henry, Philippe;  Hersey, Kimberly;  Hilty, Shannon L.;  Jacobson, Jim;  Jeffress, Mackenzie R.;  Manning, Tom;  Masching, Amy;  Maxell, Bryce;  McCollough, Rayo;  McFarland, Corrie;  Miskow, Eric;  Morelli, Toni Lyn;  Moyer-Horner, Lucas;  Mueller, Megan;  Nugent, Martin;  Pratt, Beth;  Rasmussen-Flores, Mary;  Rickman, Tom H.;  Robison, Hillary;  Rodriguez, Arthur;  Rowe, Karen;  Rowe, Kevin;  Russello, Michael A.;  Saab, Vicki;  Schmidt, Angie;  Stewart, Joseph A. E.;  Stuart, James N.;  Svancara, Leona K.;  Thompson, Will;  Timmins, Julie;  Treinish, Gregg;  Waterhouse, Matthew D.;  Westover, Marie L.;  Wilkening, Jennifer;  Yandow, Leah
收藏  |  浏览/下载:51/0  |  提交时间:2019/11/27
Is public awareness and perceived threat of climate change associated with governmental mitigation targets? 期刊论文
CLIMATIC CHANGE, 2018, 149 (2) : 159-171
作者:  Drummond, Aaron;  Hall, Lauren C.;  Sauer, James D.;  Palmer, Matthew A.
收藏  |  浏览/下载:37/0  |  提交时间:2019/04/09
Random heteropolymers preserve protein function in foreign environments 期刊论文
SCIENCE, 2018, 359 (6381) : 1239-+
作者:  Panganiban, Brian;  Qiao, Baofu;  Jiang, Tao;  DelRe, Christopher;  Obadia, Mona M.;  Trung Dac Nguyen;  Smith, Anton A. A.;  Hall, Aaron;  Sit, Izaac;  Crosby, Marquise G.;  Dennis, Patrick B.;  Drockenmuller, Eric;  de la Cruz, Monica Olvera;  Xu, Ting
收藏  |  浏览/下载:25/0  |  提交时间:2019/11/27