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Pollen PCP-B peptides unlock a stigma peptide–receptor kinase gating mechanism for pollination 期刊论文
Science, 2021
作者:  Chen Liu;  Lianping Shen;  Yu Xiao;  David Vyshedsky;  Chao Peng;  Xiang Sun;  Zhiwen Liu;  Lijun Cheng;  Hua Zhang;  Zhifu Han;  Jijie Chai;  Hen-Ming Wu;  Alice Y. Cheung;  Chao Li
收藏  |  浏览/下载:89/0  |  提交时间:2021/04/12
Nickel isotopic evidence for late-stage accretion of Mercury-like differentiated planetary embryos 期刊论文
Nature Communications, 2021
作者:  Shui-Jiong Wang;  Wenzhong Wang;  Jian-Ming Zhu;  Zhongqing Wu;  Jingao Liu;  Guilin Han;  Fang-Zhen Teng;  Shichun Huang;  Hongjie Wu;  Yujian Wang;  Guangliang Wu;  Weihan Li
收藏  |  浏览/下载:31/0  |  提交时间:2021/01/22
Quantum computational advantage using photons 期刊论文
Science, 2020
作者:  Han-Sen Zhong;  Hui Wang;  Yu-Hao Deng;  Ming-Cheng Chen;  Li-Chao Peng;  Yi-Han Luo;  Jian Qin;  Dian Wu;  Xing Ding;  Yi Hu;  Peng Hu;  Xiao-Yan Yang;  Wei-Jun Zhang;  Hao Li;  Yuxuan Li;  Xiao Jiang;  Lin Gan;  Guangwen Yang;  Lixing You;  Zhen Wang;  Li Li;  Nai-Le Liu;  Chao-Yang Lu;  Jian-Wei Pan
收藏  |  浏览/下载:83/0  |  提交时间:2020/12/22
Light grazing facilitates carbon accumulation in subsoil in Chinese grasslands: A meta‐analysis 期刊论文
Global Change Biology, 2020
作者:  Zhi‐;  Yun Jiang;  Zhong‐;  Min Hu;  Derrick Y. F. Lai;  Dao‐;  Rui Han;  Mei Wang;  Min Liu;  Meng Zhang;  Ming‐;  Yan Guo
收藏  |  浏览/下载:23/0  |  提交时间:2020/10/12
Precise pitch-scaling of carbon nanotube arrays within three-dimensional DNA nanotrenches 期刊论文
Science, 2020
作者:  Wei Sun;  Jie Shen;  Zhao Zhao;  Noel Arellano;  Charles Rettner;  Jianshi Tang;  Tianyang Cao;  Zhiyu Zhou;  Toan Ta;  Jason K. Streit;  Jeffrey A. Fagan;  Thomas Schaus;  Ming Zheng;  Shu-Jen Han;  William M. Shih;  Hareem T. Maune;  Peng Yin
收藏  |  浏览/下载:27/0  |  提交时间:2020/05/25
Self-preservation strategy for approaching global warming targets in the post-Paris Agreement era 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wei, Yi-Ming;  Han, Rong;  Wang, Ce;  Yu, Biying;  Liang, Qiao-Mei;  Yuan, Xiao-Chen;  Chang, Junjie;  Zhao, Qingyu;  Liao, Hua;  Tang, Baojun;  Yan, Jinyue;  Cheng, Lijing;  Yang, Zili
收藏  |  浏览/下载:20/0  |  提交时间:2020/05/13
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:75/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载:54/0  |  提交时间:2020/07/03
Mutational signature in colorectal cancer caused by genotoxic pks(+)E. coli 期刊论文
NATURE, 2020, 580 (7802) : 269-+
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu;  Guo, Shimeng;  Han, Gye-Won;  Li, Shaobai;  Yue, Yang;  Wei, Xiaohu;  Xie, Xin;  Chen, Yong;  Zhao, Suwen;  Wu, Jian;  Lei, Ming;  Xu, Fei
收藏  |  浏览/下载:41/0  |  提交时间:2020/07/03

Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes that synthesize colibactin(3). This compound is believed to alkylate DNA on adenine residues(4,5) and induces double-strand breaks in cultured cells(3). Here we expose human intestinal organoids to genotoxic pks(+)E. coli by repeated luminal injection over five months. Whole-genome sequencing of clonal organoids before and after this exposure revealed a distinct mutational signature that was absent from organoids injected with isogenic pks-mutant bacteria. The same mutational signature was detected in a subset of 5,876 human cancer genomes from two independent cohorts, predominantly in colorectal cancer. Our study describes a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.


Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks(+) island develop a distinct mutational signature associated with colorectal cancer.


  
Super-elastic ferroelectric single-crystal membrane with continuous electric dipole rotation 期刊论文
SCIENCE, 2019, 366 (6464) : 475-+
作者:  Dong, Guohua;  Li, Suzhi;  Yao, Mouteng;  Zhou, Ziyao;  Zhang, Yong-Qiang;  Han, Xu;  Luo, Zhenlin;  Yao, Junxiang;  Peng, Bin;  Hu, Zhongqiang;  Huang, Houbing;  Jia, Tingting;  Li, Jiangyu;  Ren, Wei;  Ye, Zuo-Guang;  Ding, Xiangdong;  Sun, Jun;  Nan, Ce-Wen;  Chen, Long-Qing;  Li, Ju;  Liu, Ming
收藏  |  浏览/下载:41/0  |  提交时间:2019/11/27