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Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil 期刊论文
Science, 2021
作者:  Nuno R. Faria;  Thomas A. Mellan;  Charles Whittaker;  Ingra M. Claro;  Darlan da S. Candido;  Swapnil Mishra;  Myuki A. E. Crispim;  Flavia C. S. Sales;  Iwona Hawryluk;  John T. McCrone;  Ruben J. G. Hulswit;  Lucas A. M. Franco;  Mariana S. Ramundo;  Jaqueline G. de Jesus;  Pamela S. Andrade;  Thais M. Coletti;  Giulia M. Ferreira;  Camila A. M. Silva;  Erika R. Manuli;  Rafael H. M. Pereira;  Pedro S. Peixoto;  Moritz U. G. Kraemer;  Nelson Gaburo;  Cecilia da C. Camilo;  Henrique Hoeltgebaum;  William M. Souza;  Esmenia C. Rocha;  Leandro M. de Souza;  Mariana C. de Pinho;  Leonardo J. T. Araujo;  Frederico S. V. Malta;  Aline B. de Lima;  Joice do P. Silva;  Danielle A. G. Zauli;  Alessandro C. de S. Ferreira;  Ricardo P. Schnekenberg;  Daniel J. Laydon;  Patrick G. T. Walker;  Hannah M. Schlüter;  Ana L. P. dos Santos;  Maria S. Vidal;  Valentina S. Del Caro;  Rosinaldo M. F. Filho;  Helem M. dos Santos;  Renato S. Aguiar;  José L. Proença-Modena;  Bruce Nelson;  James A. Hay;  Mélodie Monod;  Xenia Miscouridou;  Helen Coupland;  Raphael Sonabend;  Michaela Vollmer;  Axel Gandy;  Carlos A. Prete;  Vitor H. Nascimento;  Marc A. Suchard;  Thomas A. Bowden;  Sergei L. K. Pond;  Chieh-Hsi Wu;  Oliver Ratmann;  Neil M. Ferguson;  Christopher Dye;  Nick J. Loman;  Philippe Lemey;  Andrew Rambaut;  Nelson A. Fraiji;  Maria do P. S. S. Carvalho;  Oliver G. Pybus;  Seth Flaxman;  Samir Bhatt;  Ester C. Sabino
收藏  |  浏览/下载：45/0  |  提交时间：2021/06/07
New Guinea has the world鈥檚 richest island flora 期刊论文
Nature, 2020
作者:  Rodrigo Cá;  mara-Leret;  David G. Frodin;  Frits Adema;  Christiane Anderson;  Marc S. Appelhans;  George Argent;  Susana Arias Guerrero;  Peter Ashton;  William J. Baker;  Anders S. Barfod;  David Barrington;  Renata Borosova;  Gemma L. C. Bramley;  Marie Briggs;  Sven Buerki;  Daniel Cahen;  Martin W. Callmander;  Martin Cheek;  Cheng-Wei Chen;  Barry J. Conn;  Mark J. E. Coode;  Iain Darbyshire;  Sally Dawson;  John Dransfield;  Clare Drinkell;  Brigitta Duyfjes;  Atsushi Ebihara;  Zacky Ezedin;  Long-Fei Fu;  Osia Gideon;  Deden Girmansyah;  Rafaë;  l Govaerts;  Helen Fortune-Hopkins;  Gustavo Hassemer;  Alistair Hay;  Charlie D. Heatubun;  D. J. Nicholas Hind;  Peter Hoch;  Peter Homot;  Peter Hovenkamp;  Mark Hughes;  Matthew Jebb;  Laura Jennings;  Tiberius Jimbo;  Michael Kessler;  Ruth Kiew;  Sandra Knapp;  Penniel Lamei;  Marcus Lehnert;  Gwilym P. Lewis;  Hans Peter Linder;  Stuart Lindsay;  Yee Wen Low;  Eve Lucas;  Jeffrey P. Mancera;  Alexandre K. Monro;  Alison Moore;  David J. Middleton;  Hidetoshi Nagamasu;  Mark F. Newman;  Eimear Nic Lughadha;  Pablo H. A. Melo;  Daniel J. Ohlsen;  Caroline M. Pannell;  Barbara Parris;  Laura Pearce;  Darin S. Penneys;  Leon R. Perrie;  Peter Petoe;  Axel Dalberg Poulsen;  Ghillean T. Prance;  J. Peter Quakenbush;  Niels Raes;  Michele Rodda;  Zachary S. Rogers;  André;  Schuiteman;  Pedro Schwartsburd;  Robert W. Scotland;  Mark P. Simmons;  David A. Simpson;  Peter Stevens;  Michael Sundue;  Weston Testo;  Anna Trias-Blasi;  Ian Turner;  Timothy Utteridge;  Lesley Walsingham;  Bruce L. Webber;  Ran Wei;  George D. Weiblen;  Maximilian Weigend;  Peter Weston;  Willem de Wilde;  Peter Wilkie;  Christine M. Wilmot-Dear;  Hannah P. Wilson;  John R. I. Wood;  Li-Bing Zhang;  Peter C. van Welzen
收藏  |  浏览/下载：71/0  |  提交时间：2020/08/18
Powering the Galilean Satellites with Moon‐moon Tides 期刊论文
Geophysical Research Letters, 2020
作者:  Hamish C. F. C. Hay;  Antony Trinh;  Isamu Matsuyama
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/21
Molecular architecture of the human 17S U2 snRNP 期刊论文
NATURE, 2020, 583 (7815) : 310-+
作者:  Muench, David E.;  Olsson, Andre;  Ferchen, Kyle;  Pham, Giang;  Serafin, Rachel A.;  Chutipongtanate, Somchai;  Dwivedi, Pankaj;  Song, Baobao;  Hay, Stuart;  Chetal, Kashish;  Trump-Durbin, Lisa R.;  Mookerjee-Basu, Jayati;  Zhang, Kejian;  Yu, Jennifer C.
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/03

The U2 small nuclear ribonucleoprotein (snRNP) has an essential role in the selection of the precursor mRNA branch-site adenosine, the nucleophile for the first step of splicing'  . Stable addition of U2 during early spliceosome formation requiresthe DEAD-box ATPase PRP5(2-7). Yeast U2 small nuclear RNA (snRNA) nucleotides that form base pairs with the branch site are initially sequestered in a branchpoint-interacting stem-loop (BSL)(8), but whether the human U2 snRNA folds in a similar manner is unknown. The U2 SF3B1 protein, a common mutational target in haematopoietic cancers(9), contains a HEAT domain (SF3B1(HEAT)) with an open conformation in isolated SF3b(10), but a closed conformation in spliceosomes(11), which is required for stable interaction between U2 and the branch site. Here we report a 3D cryo-electron microscopy structure ofthe human 17S U2 snRNP at a core resolution of 4.1 angstrom and combine it with protein crosslinking data to determine the molecular architecture of this snRNP. Our structure reveals that SF3B1(HEAT) interacts with PRP5 and TAT-SF1, and maintains its open conformation in U2 snRNP, and that U2 snRNA forms a BSL that is sandwiched between PRP5, TAT-SF1 and SF3B1(HEAT). Thus, substantial remodelling of the BSL and displacement of BSL-interacting proteins must occur to allow formation of the U2-branch-site helix. Our studies provide a structural explanation of why TAT-SF1 must be displaced before the stable addition of U2 to the spliceosome, and identify RNP rearrangements facilitated by PRP5 that are required for stable interaction between U2 and the branch site.


  
Meeting the looming policy challenge of sea-level change and human migration 期刊论文
NATURE CLIMATE CHANGE, 2019, 9 (12) : 898-901
作者:  Wrathall, D. J.;  Mueller, V.;  Clark, P. U.;  Bell, A.;  Oppenheimer, M.;  Hauer, M.;  Kulp, S.;  Gilmore, E.;  Adams, H.;  Kopp, R.;  Abel, K.;  Call, M.;  Chen, J.;  deSherbinin, A.;  Fussell, E.;  Hay, C.;  Jones, B.;  Magliocca, N.;  Marino, E.;  Slangen, A.;  Warner, K.
收藏  |  浏览/下载：27/0  |  提交时间：2020/02/16
Bias in Estimates of Global Mean Sea Level Change Inferred from Satellite Altimetry 期刊论文
JOURNAL OF CLIMATE, 2018, 31 (13) : 5263-5271
作者:  Lickley, Megan Jeramaz;  Hay, Carling C.;  Tamisiea, Mark E.;  Mitrovica, Jerry X.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
Sea level  Altimetry  
Quantifying the Sensitivity of Sea Level Change in Coastal Localities to the Geometry of Polar Ice Mass Flux 期刊论文
JOURNAL OF CLIMATE, 2018, 31 (9) : 3701-3709
作者:  Mitrovica, Jerry X.;  Hay, Carling C.;  Kopp, Robert E.;  Harig, Christopher;  Latychev, Konstantin
收藏  |  浏览/下载：19/0  |  提交时间：2019/04/09
FGF-dependent metabolic control of vascular development 期刊论文
NATURE, 2017, 545 (7653) : 224-+
作者:  Yu, Pengchun;  Wilhelm, Kerstin;  Dubrac, Alexandre;  Tung, Joe K.;  Alves, Tiago C.;  Fang, Jennifer S.;  Xie, Yi;  Zhu, Jie;  Chen, Zehua;  De Smet, Frederik;  Zhang, Jiasheng;  Jin, Suk-Won;  Sun, Lele;  Sun, Hongye;  Kibbey, Richard G.;  Hirschi, Karen K.;  Hay, Nissim;  Carmeliet, Peter;  Chittenden, Thomas W.;  Eichmann, Anne;  Potente, Michael;  Simons, Michael
收藏  |  浏览/下载：19/0  |  提交时间：2019/04/09
On the Robustness of Bayesian Fingerprinting Estimates of Global Sea Level Change 期刊论文
JOURNAL OF CLIMATE, 2017, 30 (8)
作者:  Hay, Carling C.;  Morrow, Eric D.;  Kopp, Robert E.;  Mitrovica, Jerry X.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
Sea Level Fingerprints in a Region of Complex Earth Structure: The Case of WAIS 期刊论文
JOURNAL OF CLIMATE, 2017, 30 (6)
作者:  Hay, Carling C.;  Lau, Harriet C. P.;  Gomez, Natalya;  Austermann, Jacqueline;  Powell, Evelyn;  Mitrovica, Jerry X.;  Latychev, Konstantin;  Wiens, Douglas A.
收藏  |  浏览/下载：12/0  |  提交时间：2019/04/09