中文版 | English

在结果中检索

GSTDTAP

浏览/检索结果: 共50条，第1-10条 帮助

已选(0)清除 条数/页：   排序方式：
IPBES发布《野生物种可持续利用评估报告》 快报文章
资源环境快报，2022年第14期
作者:  魏艳红;  李恒吉;  裴惠娟
Microsoft Word(22Kb)  |  收藏  |  浏览/下载：732/1  |  提交时间：2022/07/31
IPBES  Wild Species  Sustainable Use  
Distinct methane-dependent biogeochemical states in Arctic seafloor gas hydrate mounds 期刊论文
Nature Communications, 2021
作者:  Klasek, Scott A.;  Hong, Wei-Li;  Torres, Marta E.;  Ross, Stella;  Hostetler, Katelyn;  Portnov, Alexey;  Grü;  ndger, Friederike;  Colwell, Frederick S.
收藏  |  浏览/下载：24/0  |  提交时间：2021/11/15
Quantum walks on a programmable two-dimensional 62-qubit superconducting processor 期刊论文
Science, 2021
作者:  Ming Gong;  Shiyu Wang;  Chen Zha;  Ming-Cheng Chen;  He-Liang Huang;  Yulin Wu;  Qingling Zhu;  Youwei Zhao;  Shaowei Li;  Shaojun Guo;  Haoran Qian;  Yangsen Ye;  Fusheng Chen;  Chong Ying;  Jiale Yu;  Daojin Fan;  Dachao Wu;  Hong Su;  Hui Deng;  Hao Rong;  Kaili Zhang;  Sirui Cao;  Jin Lin;  Yu Xu;  Lihua Sun;  Cheng Guo;  Na Li;  Futian Liang;  V. M. Bastidas;  Kae Nemoto;  W. J. Munro;  Yong-Heng Huo;  Chao-Yang Lu;  Cheng-Zhi Peng;  Xiaobo Zhu;  Jian-Wei Pan
收藏  |  浏览/下载：81/0  |  提交时间：2021/06/07
The synergistic role of sulfuric acid, bases, and oxidized organics governing new‐particle formation in Beijing 期刊论文
Geophysical Research Letters, 2021
作者:  Chao Yan;  Rujing Yin;  Yiqun Lu;  Lubna Dada;  Dongsen Yang;  Yueyun Fu;  Jenni Kontkanen;  Chenjuan Deng;  Olga Garmash;  Jiaxin Ruan;  Rima Baalbaki;  Meredith Schervish;  Runlong Cai;  Matthew Bloss;  Tommy Chan;  Tianzeng Chen;  Qi Chen;  Xuemeng Chen;  Yan Chen;  Biwu Chu;  Kaspar Dä;  llenbach;  Benjamin Foreback;  Xucheng He;  Liine Heikkinen;  Tuija Jokinen;  Heikki Junninen;  Juha Kangasluoma;  Tom Kokkonen;  Mona Kurppa;  Katrianne Lehtipalo;  Haiyan Li;  Hui Li;  Xiaoxiao Li;  Yiliang Liu;  Qingxin Ma;  Pauli Paasonen;  Pekka Rantala;  Rosaria E. Pileci;  Anton Rusanen;  Nina Sarnela;  Pauli Simonen;  Shixian Wang;  Weigang Wang;  Yonghong Wang;  Mo Xue;  Gan Yang;  Lei Yao;  Ying Zhou;  Joni Kujansuu;  Tuukka Petä;  jä;  Wei Nie;  Yan Ma;  Maofa Ge;  Hong He;  Neil M. Donahue;  Douglas R. Worsnop;  Veli‐;  Matti Kerminen;  Lin Wang;  Yongchun Liu;  Jun Zheng;  Markku Kulmala;  Jingkun Jiang;  Federico Bianchi
收藏  |  浏览/下载：60/0  |  提交时间：2021/04/06
Chemical components and source identification of PM2.5 in non-heating season in Beijing: The influences of biomass burning and dust 期刊论文
Atmospheric Research, 2020
作者:  Yanqin Ren, Jie Wei, Zhenhai Wu, Yuanyuan Ji, ... Hong Li
收藏  |  浏览/下载：32/0  |  提交时间：2020/12/28
Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques 期刊论文
Science, 2020
作者:  Wei Deng;  Linlin Bao;  Jiangning Liu;  Chong Xiao;  Jiayi Liu;  Jing Xue;  Qi Lv;  Feifei Qi;  Hong Gao;  Pin Yu;  Yanfeng Xu;  Yajin Qu;  Fengdi Li;  Zhiguang Xiang;  Haisheng Yu;  Shuran Gong;  Mingya Liu;  Guanpeng Wang;  Shunyi Wang;  Zhiqi Song;  Ying Liu;  Wenjie Zhao;  Yunlin Han;  Linna Zhao;  Xing Liu;  Qiang Wei;  Chuan Qin
收藏  |  浏览/下载：46/0  |  提交时间：2020/08/18
Differentiation Between Nitrate Aerosol Formation Pathways in a Southeast Chinese City by Dual Isotope and Modeling Studies 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Xiao, Hong-Wei;  Zhu, Ren-Guo;  Pan, Yuan-Yuan;  Guo, Wei;  Zheng, Neng-Jian;  Liu, Yong-Hui;  Liu, Cheng;  Zhang, Zhong-Yi;  Wu, Jing-Feng;  Kang, Chang-An;  Luo, Li;  Xiao, Hua-Yun
收藏  |  浏览/下载：51/0  |  提交时间：2020/08/18
Development of an inactivated vaccine candidate for SARS-CoV-2 期刊论文
Science, 2020
作者:  Qiang Gao;  Linlin Bao;  Haiyan Mao;  Lin Wang;  Kangwei Xu;  Minnan Yang;  Yajing Li;  Ling Zhu;  Nan Wang;  Zhe Lv;  Hong Gao;  Xiaoqin Ge;  Biao Kan;  Yaling Hu;  Jiangning Liu;  Fang Cai;  Deyu Jiang;  Yanhui Yin;  Chengfeng Qin;  Jing Li;  Xuejie Gong;  Xiuyu Lou;  Wen Shi;  Dongdong Wu;  Hengming Zhang;  Lang Zhu;  Wei Deng;  Yurong Li;  Jinxing Lu;  Changgui Li;  Xiangxi Wang;  Weidong Yin;  Yanjun Zhang;  Chuan Qin
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/06
Sustainable production of value-added carbon nanomaterials from biomass pyrolysis 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Zhang, Shun;  Jiang, Shun-Feng;  Huang, Bao-Cheng;  Shen, Xian-Cheng;  Chen, Wen-Jing;  Zhou, Tian-Pei;  Cheng, Hui-Yuan;  Cheng, Bin-Hai;  Wu, Chang-Zheng;  Li, Wen-Wei;  Jiang, Hong;  Yu, Han-Qing
收藏  |  浏览/下载：55/0  |  提交时间：2020/05/20
Impaired cell fate through gain-of-function mutations in a chromatin reader 期刊论文
NATURE, 2020, 577 (7788) : 121-+
作者:  Wan, Liling;  Chong, Shasha;  Xuan, Fan;  Liang, Angela;  Cui, Xiaodong;  Gates, Leah;  Carroll, Thomas S.;  Li, Yuanyuan;  Feng, Lijuan;  Chen, Guochao;  Wang, Shu-Ping;  Ortiz, Michael V.;  Daley, Sara K.;  Wang, Xiaolu;  Xuan, Hongwen;  Kentsis, Alex;  Muir, Tom W.;  Roeder, Robert G.;  Li, Haitao;  Li, Wei;  Tjian, Robert;  Wen, Hong;  Allis, C. David
收藏  |  浏览/下载：28/0  |  提交时间：2020/07/03

Modifications of histone proteins have essential roles in normal development and human disease. Recognition of modified histones by '  reader'  proteins is a key mechanism that mediates the function of histone modifications, but how the dysregulation of these readers might contribute to disease remains poorly understood. We previously identified the ENL protein as a reader of histone acetylation via its YEATS domain, linking it to the expression of cancer-driving genes in acute leukaemia1. Recurrent hotspot mutations have been found in the ENL YEATS domain in Wilms tumour2,3, the most common type of paediatric kidney cancer. Here we show, using human and mouse cells, that these mutations impair cell-fate regulation by conferring gain-of-function in chromatin recruitment and transcriptional control. ENL mutants induce gene-expression changes that favour a premalignant cell fate, and, in an assay for nephrogenesis using murine cells, result in undifferentiated structures resembling those observed in human Wilms tumour. Mechanistically, although bound to largely similar genomic loci as the wild-type protein, ENL mutants exhibit increased occupancy at a subset of targets, leading to a marked increase in the recruitment and activity of transcription elongation machinery that enforces active transcription from target loci. Furthermore, ectopically expressed ENL mutants exhibit greater self-association and form discrete and dynamic nuclear puncta that are characteristic of biomolecular hubs consisting of local high concentrations of regulatory factors. Such mutation-driven ENL self-association is functionally linked to enhanced chromatin occupancy and gene activation. Collectively, our findings show that hotspot mutations in a chromatinreader domain drive self-reinforced recruitment, derailing normal cell-fate control during development and leading to an oncogenic outcome.