GSTDTAP

浏览/检索结果: 共10条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
Atmospheric reactivity and oxidation capacity during summer at a suburban site between Beijing and Tianjin 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 8181-8200
作者:  Yang, Yuan;  Wang, Yonghong;  Zhou, Putian;  Yao, Dan;  Ji, Dongsheng;  Sun, Jie;  Wang, Yinghong;  Zhao, Shuman;  Huang, Wei;  Yang, Shuanghong;  Chen, Dean;  Gao, Wenkang;  Liu, Zirui;  Hu, Bo;  Zhang, Renjian;  Zeng, Limin;  Ge, Maofa;  Petaja, Tuukka;  Kerminen, Veli-Matti;  Kulmala, Markku;  Wang, Yuesi
收藏  |  浏览/下载:58/0  |  提交时间:2020/08/18
Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation 期刊论文
Environmental Health Perspectives, 2020
作者:  Lishi Xie;  Wen-Yang Hu;  Dan-Ping Hu;  Guangbin Shi;  Ye Li;  Jianfu Yang;  Gail S. Prins
收藏  |  浏览/下载:15/0  |  提交时间:2020/06/16
Fast sulfate formation from oxidation of SO2 by NO2 and HONO observed in Beijing haze 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Wang, Junfeng;  Li, Jingyi;  Ye, Jianhuai;  Zhao, Jian;  Wu, Yangzhou;  Hu, Jianlin;  Liu, Dantong;  Nie, Dongyang;  Shen, Fuzhen;  Huang, Xiangpeng;  Huang, Dan Dan;  Ji, Dongsheng;  Sun, Xu;  Xu, Weiqi;  Guo, Jianping;  Song, Shaojie;  Qin, Yiming;  Liu, Pengfei;  Turner, Jay R.;  Lee, Hyun Chul;  Hwang, Sungwoo;  Liao, Hong;  Martin, Scot T.;  Zhang, Qi;  Chen, Mindong;  Sun, Yele;  Ge, Xinlei;  Jacob, Daniel J.
收藏  |  浏览/下载:56/0  |  提交时间:2020/06/09
Plastic pollution in croplands threatens long‐term food security 期刊论文
Global Change Biology, 2020
作者:  Dan Zhang;  Ee Ling Ng;  Wanli Hu;  Hongyuan Wang;  Pablo Galaviz;  Hude Yang;  Wentao Sun;  Chongxiao Li;  Xingwang Ma;  Bin Fu;  Peiyi Zhao;  Fulin Zhang;  Shuqin Jin;  Mingdong Zhou;  Lianfeng Du;  Chang Peng;  Xuejun Zhang;  Zhiyu Xu;  Bin Xi;  Xiaoxia Liu;  Shiyou Sun;  Zhenhua Cheng;  Lihua Jiang;  Yufeng Wang;  Liang Gong;  Changlin Kou;  Yan Li;  Youhua Ma;  Dongfeng Huang;  Jian Zhu;  Jianwu Yao;  Chaowen Lin;  Song Qin;  Liuqiang Zhou;  Binghui He;  Deli Chen;  Huanchun Li;  Limei Zhai;  Qiuliang Lei;  Shuxia Wu;  Yitao Zhang;  Junting Pan;  Baojing Gu;  Hongbin Liu
收藏  |  浏览/下载:50/0  |  提交时间:2020/05/13
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:75/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Paleomagnetic Constraints on the Origin and Drift History of the North Qiangtang Terrane in the Late Paleozoic 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (2) : 689-697
作者:  Ma, Yiming;  Wang, Qiang;  Wang, Jun;  Yang, Tianshui;  Tan, Xiaodong;  Dan, Wei;  Zhang, Xiuzheng;  Ma, Lin;  Wang, Zilong;  Hu, Wanlong;  Zhang, Shihong;  Wu, Huaichun;  Li, Haiyan;  Cao, Liwan
收藏  |  浏览/下载:20/0  |  提交时间:2019/04/09
Evaluation of Bisphenol A (BPA) Exposures on Prostate Stem Cell Homeostasis and Prostate Cancer Risk in the NCTR-Sprague-Dawley Rat: An NIEHS/FDA CLARITY-BPA Consortium Study 期刊论文
ENVIRONMENTAL HEALTH PERSPECTIVES, 2018, 126 (11)
作者:  Prins, Gail S.;  Hu, Wen-Yang;  Xie, Lishi;  Shi, Guang-Bin;  Hu, Dan-Ping;  Birch, Lynn;  Bosland, Maarten C.
收藏  |  浏览/下载:19/0  |  提交时间:2019/04/09
Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Qi, Ji;  Chen, Chao;  Zhang, Xiaoyan;  Hu, Xianglong;  Ji, Shenglu;  Kwok, Ryan T. K.;  Lam, Jacky W. Y.;  Ding, Dan;  Tang, Ben Zhong
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27
Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Lv, Jian-Ming;  Hu, Dan;  Gao, Hao;  Kushiro, Tetsuo;  Awakawa, Takayoshi;  Chen, Guo-Dong;  Wang, Chuan-Xi;  Abe, Ikuro;  Yao, Xin-Sheng
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
城市建筑与设施的三维空间结构对典型微气候及大气污染过程的影响与生态优化模式研究 项目
项目编号:41571482; 经费:650000(CNY); 起止日期:2016 / dc_date_end
项目负责人:  胡聃
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/11