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Sialylation of immunoglobulin E is a determinant of allergic pathogenicity 期刊论文
NATURE, 2020, 582 (7811) : 265-+
作者:  Abdul-Masih, Michael;  Banyard, Gareth;  Bodensteiner, Julia;  Bordier, Emma;  Bowman, Dominic M.;  Dsilva, Karan;  Fabry, Matthias;  Hawcroft, Calum;  Mahy, Laurent;  Marchant, Pablo;  Raskin, Gert;  Reggiani, Maddalena;  Shenar, Tomer;  Tkachenko, Andrew;  Van Winckel, Hans;  Vermeylen, Lore;  Sana, Hugues
收藏  |  浏览/下载：17/0  |  提交时间：2020/07/03

A specific type of glycosylation-sialylation-is more common on immunoglobulin E from individuals with a peanut allergys than from non-atopic people, suggesting that it has a role in regulating anaphylaxis.


Approximately one-third of the world'  s population suffers from allergies(1). Exposure to allergens crosslinks immunoglobulin E (IgE) antibodies that are bound to mast cells and basophils, triggering the release of inflammatory mediators, including histamine(2). Although IgE is absolutely required for allergies, it is not understood why total and allergen-specific IgE concentrations do not reproducibly correlate with allergic disease(3-5). It is well-established that glycosylation of IgG dictates its effector function and has disease-specific patterns. However, whether IgE glycans differ in disease states or affect biological activity is completely unknown(6). Here we perform an unbiased examination of glycosylation patterns of total IgE from individuals with a peanut allergy and from non-atopic individuals without allergies. Our analysis reveals an increase in sialic acid content on total IgE from individuals with a peanut allergy compared with non-atopic individuals. Removal of sialic acid from IgE attenuates effector-cell degranulation and anaphylaxis in several functional models of allergic disease. Therapeutic interventions-including removing sialic acid from cell-bound IgE with a neuraminidase enzyme targeted towards the IgE receptor Fc epsilon RI, and administering asialylated IgE-markedly reduce anaphylaxis. Together, these results establish IgE glycosylation, and specifically sialylation, as an important regulator of allergic disease.


  
Quantum interface of an electron and a nuclear ensemble 期刊论文
SCIENCE, 2019, 364 (6435) : 62-+
作者:  Gangloff, D. A.;  Ethier-Majcher, G.;  Lang, C.;  Denning, E. V.;  Bodey, J. H.;  Jackson, D. M.;  Clarke, E.;  Hugues, M.;  Le Gall, C.;  Atature, M.
收藏  |  浏览/下载：3/0  |  提交时间：2019/11/27
Developing policy-relevant biodiversity indicators: lessons learnt from case studies in Africa 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (3)
作者:  Rochette, Anne-Julie;  Akpona, Jean Didier T.;  Akpona, Hugues Adeloui;  Akouehou, Gaston S.;  Kwezi, Blanchard Mayundo;  Djagoun, Chabi A. M. S.;  Habonimana, Bernadette;  Idohou, Rodrigue;  Legba, Ingride S.;  Nzigidahera, Benoit;  Matilo, Augustin Orou;  Taleb, Mohammed Sghir;  Bamoninga, Benjamin Toirambe;  Ivory, Sarah;  de Bisthoven, Luc Janssens;  Vanhove, Maarten P. M.
收藏  |  浏览/下载：21/0  |  提交时间：2019/04/09
science-policy interface  monitoring  reporting  verification  capacity building  biodiversity indicators  
The response of soil solution chemistry in European forests to decreasing acid deposition 期刊论文
GLOBAL CHANGE BIOLOGY, 2018, 24 (8) : 3603-3619
作者:  Johnson, James;  Pannatier, Elisabeth Graf;  Carnicelli, Stefano;  Cecchini, Guia;  Clarke, Nicholas;  Cools, Nathalie;  Hansen, Karin;  Meesenburg, Henning;  Nieminen, Tiina M.;  Pihl-Karlsson, Gunilla;  Titeux, Hugues;  Vanguelova, Elena;  Verstraeten, Arne;  Vesterdal, Lars;  Waldner, Peter;  Jonard, Mathieu
收藏  |  浏览/下载：12/0  |  提交时间：2019/04/09
acid deposition  air pollution  aluminium  critical loads  dissolved organic carbon  nitrogen  soil acidification  sulphur  
Response to Comment on "An excess of massive stars in the local 30 Doradus starburst" 期刊论文
SCIENCE, 2018, 361 (6400)
作者:  Schneider, Fabian R. N.;  Sana, Hugues;  Evans, Christopher J.;  Bestenlehner, Joachim M.;  Castro, Norberto;  Fossati, Luca;  Graefener, Goetz;  Langer, Norbert;  Ramirez-Agudelo, Oscar H.;  Sabin-Sanjulian, Carolina;  Simon-Diaz, Sergio;  Tramper, Frank;  Crowther, Paul A.;  de Koter, Alexander;  de Mink, Selma E.;  Dufton, Philip L.;  Garcia, Miriam;  Gieles, Mark;  Henault-Brunet, Vincent;  Herrero, Artemio;  Izzard, Robert G.;  Kalari, Venu;  Lennon, Danny J.;  Maiz Apellaniz, Jesus;  Markova, Nevy;  Najarro, Francisco;  Podsiadlowski, Philipp;  Puls, Joachim;  Taylor, William D.;  van Loon, Jacco Th.;  Vink, Jorick S.;  Norman, Colin
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27