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Nitrous oxide emissions from drying streams and rivers 期刊论文
Geophysical Research Letters, 2021
作者:  D. Tonina;  A. Marzadri;  A. Bellin;  M. M. Dee;  S. Bernal;  J. L. Tank
收藏  |  浏览/下载:23/0  |  提交时间:2021/12/15
IGF1R is an entry receptor for respiratory syncytial virus 期刊论文
NATURE, 2020, 583 (7817) : 615-+
作者:  Pasquina-Lemonche, L.;  Burns, J.;  Turner, R. D.;  Kumar, S.;  Tank, R.;  Mullin, N.;  Wilson, J. S.;  Chakrabarti, B.;  Bullough, P. A.;  Foster, S. J.;  Hobbs, J. K.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Respiratory syncytial virus enters cells by binding to cell-surface IGFR1, which activates PKC zeta and induces trafficking of the NCL coreceptor to the RSV particles at the cell surface.


Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human health, for which there are few therapeutic options(1). RSV targets ciliated epithelial cells in the airways, but how viruses such as RSV interact with receptors on these cells is not understood. Nucleolin is an entry coreceptor for RSV2 and also mediates the cellular entry of influenza, the parainfluenza virus, some enteroviruses and the bacterium that causes tularaemia(3,4). Here we show a mechanism of RSV entry into cells in which outside-in signalling, involving binding of the prefusion RSV-F glycoprotein with the insulin-like growth factor-1 receptor, triggers the activation of protein kinase C zeta (PKC zeta). This cellular signalling cascade recruits nucleolin from the nuclei of cells to the plasma membrane, where it also binds to RSV-F on virions. We find that inhibiting PKC zeta activation prevents the trafficking of nucleolin to RSV particles on airway organoid cultures, and reduces viral replication and pathology in RSV-infected mice. These findings reveal a mechanism of virus entry in which receptor engagement and signal transduction bring the coreceptor to viral particles at the cell surface, and could form the basis of new therapeutics to treat RSV infection.


  
Widespread and Accelerated Decrease of Observed Mean and Extreme Snow Depth Over Europe 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (22) : 12312-12319
作者:  Bach, A. Fontrodona;  van der Schrier, G.;  Melsen, L. A.;  Tank, A. M. G. Klein;  Teuling, A. J.
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/09
snow depth  decreasing  widespread  acceleration  Europe  
Abnormal RNA stability in amyotrophic lateral sclerosis 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Tank, E. M.;  Figueroa-Romero, C.;  Hinder, L. M.;  Bed, K.;  Archbold, H. C.;  Li, X.;  Weskamp, K.;  Safren, N.;  Paez-Colasante, X.;  Pacut, C.;  Thumma, S.;  Paulsen, M. T.;  Guo, K.;  Hur, J.;  Ljungman, M.;  Feldman, E. L.;  Barmada, S. J.
收藏  |  浏览/下载:24/0  |  提交时间:2019/11/27
West Africa climate extremes and climate change indices 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38: E921-E938
作者:  Barry, A. A.;  Caesar, J.;  Tank, A. M. G. Klein;  Aguilar, E.;  McSweeney, Carol;  Cyrille, Ahmed M.;  Nikiema, M. P.;  Narcisse, K. B.;  Sima, F.;  Stafford, G.;  Touray, L. M.;  Ayilari-Naa, J. A.;  Mendes, C. L.;  Tounkara, M.;  Gar-Glahn, Eugene V. S.;  Coulibaly, M. S.;  Dieh, M. F.;  Mouhaimouni, M.;  Oyegade, J. A.;  Sambou, E.;  Laogbessi, E. T.
收藏  |  浏览/下载:21/0  |  提交时间:2019/04/09
climate extremes  West Africa  indices  trends  climate change  daily temperature  daily precipitation  
Foundations of translational ecology 期刊论文
FRONTIERS IN ECOLOGY AND THE ENVIRONMENT, 2017, 15 (10)
作者:  Enquist, Carolyn A. F.;  Jackson, Stephen T.;  Garfin, Gregg M.;  Davis, Frank W.;  Gerber, Leah R.;  Littell, Jeremy A.;  Tank, Jennifer L.;  Terando, Adam J.;  Wall, Tamara U.;  Halpern, Benjamin;  Hiers, J. Kevin;  Morelli, Toni Lyn;  McNie, Elizabeth;  Stephenson, Nathan L.;  Williamson, Matthew A.;  Woodhouse, Connie A.;  Yung, Laurie;  Brunson, Mark W.;  Hall, Kimberly R.;  Hallett, Lauren M.;  Lawson, Dawn M.;  Moritz, Max A.;  Nydick, Koren;  Pairis, Amber;  Ray, Andrea J.;  Regan, Claudia;  Safford, Hugh D.;  Schwartz, Mark W.;  Shaw, M. Rebecca
收藏  |  浏览/下载:32/0  |  提交时间:2019/04/09
Scaling Dissolved Nutrient Removal in River Networks: A Comparative Modeling Investigation 期刊论文
WATER RESOURCES RESEARCH, 2017, 53 (11)
作者:  Ye, Sheng;  Reisinger, Alexander J.;  Tank, Jennifer L.;  Baker, Michelle A.;  Hall, Robert O.;  Rosi, Emma J.;  Sivapalan, Murugesu
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09
nutrient uptake  rivers  hydrology  biogeochemistry  network modeling  field experiments  scale effects