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Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity 期刊论文
Science, 2021
作者:  Parsa Akbari;  Ankit Gilani;  Olukayode Sosina;  Jack A. Kosmicki;  Lori Khrimian;  Yi-Ya Fang;  Trikaldarshi Persaud;  Victor Garcia;  Dylan Sun;  Alexander Li;  Joelle Mbatchou;  Adam E. Locke;  Christian Benner;  Niek Verweij;  Nan Lin;  Sakib Hossain;  Kevin Agostinucci;  Jonathan V. Pascale;  Ercument Dirice;  Michael Dunn;  Regeneron Genetics Center‡;  DiscovEHR Collaboration‡;  William E. Kraus;  Svati H. Shah;  Yii-Der I. Chen;  Jerome I. Rotter;  Daniel J. Rader;  Olle Melander;  Christopher D. Still;  Tooraj Mirshahi;  David J. Carey;  Jaime Berumen-Campos;  Pablo Kuri-Morales;  Jesus Alegre-Díaz;  Jason M. Torres;  Jonathan R. Emberson;  Rory Collins;  Suganthi Balasubramanian;  Alicia Hawes;  Marcus Jones;  Brian Zambrowicz;  Andrew J. Murphy;  Charles Paulding;  Giovanni Coppola;  John D. Overton;  Jeffrey G. Reid;  Alan R. Shuldiner;  Michael Cantor;  Hyun M. Kang;  Goncalo R. Abecasis;  Katia Karalis;  Aris N. Economides;  Jonathan Marchini;  George D. Yancopoulos;  Mark W. Sleeman;  Judith Altarejos;  Giusy Della Gatta;  Roberto Tapia-Conyer;  Michal L. Schwartzman;  Aris Baras;  Manuel A. R. Ferreira;  Luca A. Lotta
收藏  |  浏览/下载:62/0  |  提交时间:2021/07/27
A remnant planetary core in the hot-Neptune desert 期刊论文
NATURE, 2020, 583 (7814) : 39-+
作者:  David J. Armstrong;  Thé;  o A. Lopez;  Vardan Adibekyan;  Richard A. Booth;  Edward M. Bryant;  Karen A. Collins;  Magali Deleuil;  Alexandre Emsenhuber;  Chelsea X. Huang;  George W. King;  Jorge Lillo-Box;  Jack J. Lissauer;  Elisabeth Matthews;  Olivier Mousis;  Louise D. Nielsen;  Hugh Osborn;  Jon Otegi;  Nuno C. Santos;  ;  rgio G. Sousa;  Keivan G. Stassun;  Dimitri Veras;  Carl Ziegler;  Jack S. Acton;  Jose M. Almenara;  David R. Anderson;  David Barrado;  Susana C. C. Barros;  Daniel Bayliss;  Claudia Belardi;  Francois Bouchy;  ;  sar Briceñ;  o;  Matteo Brogi;  David J. A. Brown;  Matthew R. Burleigh;  Sarah L. Casewell;  Alexander Chaushev;  David R. Ciardi;  Kevin I. Collins;  Knicole D. Coló;  n;  Benjamin F. Cooke;  Ian J. M. Crossfield;  Rodrigo F. Dí;  az;  Elisa Delgado Mena;  Olivier D. S. Demangeon;  Caroline Dorn;  Xavier Dumusque;  Philipp Eigmü;  ller;  Michael Fausnaugh;  Pedro Figueira;  Tianjun Gan;  Siddharth Gandhi;  Samuel Gill;  Erica J. Gonzales;  Michael R. Goad;  Maximilian N. Gü;  nther;  Ravit Helled;  Saeed Hojjatpanah;  Steve B. Howell;  James Jackman;  James S. Jenkins;  Jon M. Jenkins;  Eric L. N. Jensen;  Grant M. Kennedy;  David W. Latham;  Nicholas Law;  Monika Lendl;  Michael Lozovsky;  Andrew W. Mann;  Maximiliano Moyano;  James McCormac;  Farzana Meru;  Christoph Mordasini;  Ares Osborn;  Don Pollacco;  Didier Queloz;  Liam Raynard;  George R. Ricker;  Pamela Rowden;  Alexandre Santerne;  Joshua E. Schlieder;  Sara Seager;  Lizhou Sha;  Thiam-Guan Tan;  Rosanna H. Tilbrook;  Eric Ting;  Sté;  phane Udry;  Roland Vanderspek;  Christopher A. Watson;  Richard G. West;  Paul A. Wilson;  Joshua N. Winn;  Peter Wheatley;  Jesus Noel Villasenor;  Jose I. Vines;  Zhuchang Zhan
收藏  |  浏览/下载:84/0  |  提交时间:2020/07/06

The interiors of giant planets remain poorly understood. Even for the planets in the Solar System, difficulties in observation lead to large uncertainties in the properties of planetary cores. Exoplanets that have undergone rare evolutionary processes provide a route to understanding planetary interiors. Planets found in and near the typically barren hot-Neptune '  desert'  (1,2)(a region in mass-radius space that contains few planets) have proved to be particularly valuable in this regard. These planets include HD149026b(3), which is thought to have an unusually massive core, and recent discoveries such as LTT9779b(4)and NGTS-4b(5), on which photoevaporation has removed a substantial part of their outer atmospheres. Here we report observations of the planet TOI-849b, which has a radius smaller than Neptune'  s but an anomalously large mass of39.1-2.6+2.7Earth masses and a density of5.2-0.8+0.7grams per cubic centimetre, similar to Earth'  s. Interior-structure models suggest that any gaseous envelope of pure hydrogen and helium consists of no more than3.9-0.9+0.8 per cent of the total planetary mass. The planet could have been a gas giant before undergoing extreme mass loss via thermal self-disruption or giant planet collisions, or it could have avoided substantial gas accretion, perhaps through gap opening or late formation(6). Although photoevaporation rates cannot account for the mass loss required to reduce a Jupiter-like gas giant, they can remove a small (a few Earth masses) hydrogen and helium envelope on timescales of several billion years, implying that any remaining atmosphere on TOI-849b is likely to be enriched by water or other volatiles from the planetary interior. We conclude that TOI-849b is the remnant core of a giant planet.


Observations of TOI-849b reveal a radius smaller than Neptune'  s but a large mass of about 40 Earth masses, indicating that the planet is the remnant core of a gas giant.


  
Africa's Climate Response to Solar Radiation Management With Stratospheric Aerosol 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (2)
作者:  Pinto, Izidine;  Jack, Christopher;  Lennard, Christopher;  Tilmes, Simone;  Odoulami, Romaric C.
收藏  |  浏览/下载:20/0  |  提交时间:2020/07/02
Africa  SRM  impact  extreme  climate  
Design of an invitro biocatalytic cascade for the manufacture of islatravir 期刊论文
SCIENCE, 2019, 366 (6470) : 1255-+
作者:  Huffman, Mark A.;  Fryszkowska, Anna;  Alvizo, Oscar;  Borra-Garske, Margie;  Campos, Kevin R.;  Canada, Keith A.;  Devine, Paul N.;  Duan, Da;  Forstater, Jacob H.;  Grosser, Shane T.;  Halsey, Holst M.;  Hughes, Gregory J.;  Jo, Junyong;  Joyce, Leo A.;  Kolev, Joshua N.;  Liang, Jack;  Maloney, Kevin M.;  Mann, Benjamin F.;  Marshall, Nicholas M.;  McLaughlin, Mark;  Moore, Jeffrey C.;  Murphy, Grant S.;  Nawrat, Christopher C.;  Nazor, Jovana;  Novick, Scott;  Patel, Niki R.;  Rodriguez-Granillo, Agustina;  Robaire, Sandra A.;  Sherer, Edward C.;  Truppo, Matthew D.;  Whittaker, Aaron M.;  Verma, Deeptak;  Xiao, Li;  Xu, Yingju;  Yang, Hao
收藏  |  浏览/下载:42/0  |  提交时间:2020/02/17
What can we know about future precipitation in Africa? Robustness, significance and added value of projections from a large ensemble of regional climate models 期刊论文
CLIMATE DYNAMICS, 2019, 53: 5833-5858
作者:  Dosio, Alessandro;  Jones, Richard G.;  Jack, Christopher;  Lennard, Christopher;  Nikulin, Grigory;  Hewitson, Bruce
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
CORDEX-Africa  RCMs  GCMs  Added value  
Climate process chains: Examples from southern Africa 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (12) : 4784-4797
作者:  Daron, Joseph;  Burgin, Laura;  Janes, Tamara;  Jones, Richard G.;  Jack, Christopher
收藏  |  浏览/下载:16/0  |  提交时间:2019/11/27
teleconnections  rainfall  uncertainties  climate model evaluation  
Evaluation of downscaling methods over Europe: Results of the EU-COST action VALUE 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (9) : 3689-3691
作者:  Jack, Christopher;  Katragkou, Eleni
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Consent insufficient for data release Response 期刊论文
SCIENCE, 2019, 364 (6439) : 446-446
作者:  Amann, Rudolf I.;  Baichoo, Shakuntala;  Blencowe, Benjamin J.;  Bork, Peer;  Borodovsky, Mark;  Brooksbank, Cath;  Chain, Patrick S. G.;  Colwell, Rita R.;  Daffonchio, Daniele G.;  Danchin, Antoine;  de Lorenzo, Victor;  Dorrestein, Pieter C.;  Finn, Robert D.;  Fraser, Claire M.;  Gilbert, Jack A.;  Hallam, Steven J.;  Hugenholtz, Philip;  Ioannidis, John P. A.;  Jansson, Janet K.;  Kim, Jihyun F.;  Klenk, Hans-Peter;  Klotz, Martin G.;  Knight, Rob;  Konstantinidis, Konstantinos T.;  Kyrpides, Nikos C.;  Mason, Christopher E.;  McHardy, Alice C.;  Meyer, Folker;  Ouzounis, Christos A.;  Patrinos, Aristides A. N.;  Podar, Mircea;  Pollard, Katherine S.;  Ravel, Jacques;  Munoz, Alejandro Reyes;  Roberts, Richard J.;  Rossello-Mora, Ramon;  Sansone, Susanna-Assunta;  Schloss, Patrick D.;  Schriml, Lynn M.;  Setubal, Joao C.;  Sorek, Rotem;  Stevens, Rick L.;  Tiedje, James M.;  Turjanski, Adrian;  Tyson, Gene W.;  Ussery, David W.;  Weinstock, George M.;  White, Owen;  Whitman, William B.;  Xenarios, Ioannis
收藏  |  浏览/下载:53/0  |  提交时间:2019/11/27
A Methodological Approach to Assess the Co-Behavior of Climate Processes over Southern Africa 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (9) : 2483-2495
作者:  Quagraine, Kwesi A.;  Hewitson, Bruce;  Jack, Christopher;  Pinto, Izidine;  Lennard, Christopher
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/26
Antarctic Oscillation  ENSO  Indices  Climate variability  Climatology  Principal components analysis  
Toward unrestricted use of public genomic data 期刊论文
SCIENCE, 2019, 363 (6425) : 350-+
作者:  Amann, Rudolf I.;  Baichoo, Shakuntala;  Blencowe, Benjamin J.;  Bork, Peer;  Borodovsky, Mark;  Brooksbank, Cath;  Chain, Patrick S. G.;  Colwell, Rita R.;  Daffonchio, Daniele G.;  Danchin, Antoine;  de Lorenzo, Victor;  Dorrestein, Pieter C.;  Finn, Robert D.;  Fraser, Claire M.;  Gilbert, Jack A.;  Hallam, Steven J.;  Hugenholtz, Philip;  Ioannidis, John P. A.;  Jansson, Janet K.;  Kim, Jihyun F.;  Klenk, Hans-Peter;  Klotz, Martin G.;  Knight, Rob;  Konstantinidis, Konstantinos T.;  Kyrpides, Nikos C.;  Mason, Christopher E.;  McHardy, Alice C.;  Meyer, Folker;  Ouzounis, Christos A.;  Patrinos, Aristides A. N.;  Podar, Mircea;  Pollard, Katherine S.;  Ravel, Jacques;  Munoz, Alejandro Reyes;  Roberts, Richard J.;  Rossello-Mora, Ramon;  Sansone, Susanna-Assunta;  Schloss, Patrick D.;  Schriml, Lynn M.;  Setubal, Jogo C.;  Sorek, Rotem;  Stevens, Rick L.;  Tiedje, James M.;  Turjanski, Adrian;  Tyson, Gene W.;  Ussery, David W.;  Weinstock, George M.;  White, Owen;  Whitman, William B.;  Xenarios, Ioannis
收藏  |  浏览/下载:42/0  |  提交时间:2019/11/27