GSTDTAP

浏览/检索结果: 共11条,第1-10条 帮助

已选(0)清除 条数/页:   排序方式:
Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2 期刊论文
Science, 2021
作者:  Rui Bai;  Ruixue Wan;  Chuangye Yan;  Qi Jia;  Jianlin Lei;  Yigong Shi
收藏  |  浏览/下载:31/0  |  提交时间:2021/01/15
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:75/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Effect of Aerosols on the Ice Cloud Properties Over the Tibetan Plateau 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (16) : 9594-9608
作者:  Liu, Yuzhi;  Hua, Shan;  Jia, Rui;  Huang, Jianping
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
aerosol  ice cloud  cloud droplet radius  cloud optical property  Tibetan Plateau  
Role of clouds in accelerating cold-season warming during 2000-2015 over the Tibetan Plateau 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2018, 38 (13) : 4950-4966
作者:  Hua, Shan;  Liu, Yuzhi;  Jia, Rui;  Chang, Shuting;  Wu, Chuqiao;  Zhu, Qingzhe;  Shao, Tianbin;  Wang, Bing
收藏  |  浏览/下载:14/0  |  提交时间:2019/04/09
cloud  cloud radiative forcing  Tibetan plateau  warming  
Interdecadal Change of the Impact of Eurasian Snow on Spring Precipitation Over Southern China 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (18) : 10073-10089
作者:  Jia, Xiaojing;  Cao, Ding Rui;  Ge, Jing Wen;  Wang, Min
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/09
spring precipitation  snow cover extent  interdecadal change  numerical model  
Evolving Relative Importance of the Southern Ocean and North Atlantic in Anthropogenic Ocean Heat Uptake 期刊论文
JOURNAL OF CLIMATE, 2018, 31 (18) : 7459-7479
作者:  Shi, Jia-Rui;  Xie, Shang-Ping;  Talley, Lynne D.
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09
Air-sea interaction  Anthropogenic effects  Climate change  Heat budgets  fluxes  Climate models  
Role of ambient ammonia in particulate ammonium formation at a rural site in the North China Plain 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (1) : 167-184
作者:  Meng, Zhaoyang;  Xu, Xiaobin;  Lin, Weili;  Ge, Baozhu;  Xie, Yulin;  Song, Bo;  Jia, Shihui;  Zhang, Rui;  Peng, Wei;  Wang, Ying;  Cheng, Hongbing;  Yang, Wen;  Zhao, Huarong
收藏  |  浏览/下载:26/0  |  提交时间:2019/04/09
Lower tropospheric distributions of O-3 and aerosol over Raoyang, a rural site in the North China Plain 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (6)
作者:  Wang, Rui;  Xu, Xiaobin;  Jia, Shihui;  Ma, Ruisheng;  Ran, Liang;  Deng, Zhaoze;  Lin, Weili;  Wang, Ying;  Ma, Zhiqiang
收藏  |  浏览/下载:26/0  |  提交时间:2019/04/09
Bug mapping and fitness testing of chemically synthesized chromosome X 期刊论文
SCIENCE, 2017, 355 (6329)
作者:  Wu, Yi;  Li, Bing-Zhi;  Zhao, Meng;  Mitchell, Leslie A.;  Xie, Ze-Xiong;  Lin, Qiu-Hui;  Wang, Xia;  Xiao, Wen-Hai;  Wang, Ying;  Zhou, Xiao;  Liu, Hong;  Li, Xia;  Ding, Ming-Zhu;  Liu, Duo;  Zhang, Lu;  Liu, Bao-Li;  Wu, Xiao-Le;  Li, Fei-Fei;  Dong, Xiu-Tao;  Jia, Bin;  Zhang, Wen-Zheng;  Jiang, Guo-Zhen;  Liu, Yue;  Bai, Xue;  Song, Tian-Qing;  Chen, Yan;  Zhou, Si-Jie;  Zhu, Rui-Ying;  Gao, Feng;  Kuang, Zheng;  Wang, Xuya;  Shen, Michael;  Yang, Kun;  Stracquadanio, Giovanni;  Richardson, Sarah M.;  Lin, Yicong;  Wang, Lihui;  Walker, Roy;  Luo, Yisha;  Ma, Ping-Sheng;  Yang, Huanming;  Cai, Yizhi;  Dai, Junbiao;  Bader, Joel S.;  Boeke, Jef D.;  Yuan, Ying-Jin
收藏  |  浏览/下载:50/0  |  提交时间:2019/11/27
盐类低温钻井液对天然气水合物相平衡和分解动力学影响的研究 项目
项目编号:41502343; 经费:200000(CNY); 起止日期:2016 / dc_date_end
项目负责人:  贾瑞
收藏  |  浏览/下载:17/0  |  提交时间:2019/04/11